Factory source China Methyl Xanthine Base Class Materials - Hydrocortisone – Tecsun
Factory source China Methyl Xanthine Base Class Materials - Hydrocortisone – Tecsun Detail:
| Product name | Hydrocortisone Base Micro EP 8.0 |
| CAS | 50-23-7 |
| HS CODE | 2937210000 |
| Expiry | 4 Years |
| Package | 25kg/drum |
| Standard | EP |
| Appearance | White crystalline powder |
| Specific rotation (on the dries base)(+º) | 162-168 |
| Related Substance | Impurity A (%)≤0.2% |
| Impurity B (%)≤0.2% | |
| Impurity C (%)≤0.5% | |
| Impurity D (%)≤0.5% | |
| Impurity E (%)≤0.5% | |
| Impurity F (%)≤0.3% | |
| Impurity G (%)≤0.4% | |
| Impurity H (%)≤0.15% | |
| Impurity I (%)≤0.5% | |
| Impurity N (%)≤0.15% | |
| Any other individual impurity(%) ≤0.1% | |
| Total impurity(%)≤ 2.0% | |
| Loss on Drying | ≤1.0% |
| .Residue on Ignition | ≤0.1% |
| Heavy metals | ≤10ppm |
| Residual solvents | 1,2 Dichloroethane Ethanol≤5% |
| methanol≤1000ppm | |
| Chloroform≤60ppm | |
| Microbial limit | Total aerobic microbial count (cfu/g)≤800 |
| Fungi (cfu/g)≤60 | |
| E.coli (cfu/g) not found | |
| Particle size | 90% <5um |
| Assay | 97.0~103.0 |
| Function | |
| Hydrocortisone is a synthetic and naturally occurring glucocorticoid with an anti-inflammatory effect of 1.25 times that of cortisone. It also has immunosuppressive, anti-toxic, anti-shock and certain mineralocorticoid activities. There are water retention, sodium retention and potassium excretion. Both pharmacological and non-infectious inflammation are inhibited at pharmacological doses. Hydrocortisone can increase vascular tone, reduce congestion, reduce capillary permeability, thereby reducing exudation and edema; inhibiting the accumulation of inflammatory cells (including macrophages and leukocytes) at the site of inflammation and inhibiting phagocytosis The function of the cell stabilizes the lysosomal membrane, prevents complement from participating in the inflammatory response, and the synthesis and release of inflammatory chemical mediators (such as prostaglandins, thromboxane, leukotrienes), thereby alleviating redness, swelling, heat, pain and other symptoms. Hydrocortisone and other glucocorticoids can improve the body's ability to stress harmful stimuli, reduce the damage of bacterial endotoxin to the body, alleviate the symptoms of toxemia, and have fever for the high fever of toxemia. effect. The antipyretic mechanism may be related to inhibiting the reaction of the body temperature center to the pyrogen, stabilizing the lysosomal membrane, and reducing the release of endogenous pyrogens |
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