What is streptomycin sulfate ?

Streptomycin sulfate is an aminocyclitol glycoside antibiotic which interferes with protein synthesis in prokaryotes.

This Streptomycin sulfate antibiotic is effective against both gram-positive and gram-negative bacteria and is frequently used in cell culture media.
Streptomycin inhibits protein synthesis by binding to the 30S ribosomal subunit at the S12 protein thereby inducing a misreading of the genetic code, inhibiting the initiation of translation of DNA which then results in death for a susceptible bacterium.

Function of streptomycin sulfate

An antibiotic produced by the soil actinomycete Streptomyces griseus. Streptomyces acts by inhibiting the initiation and elongation processes during protein synthesis.

For tularemia, plague, brucellosis and glanders serious treatment (often combined with tetracycline or chloramphenicol). Also used second-line treatment of TB and multi-combination with other anti-TB drugs.

Application of streptomycin sulfate

 
streptomycin sulfate is Used for tuberculosis, brinell and non hemolytic hammer coli caused by infective endocarditis, plague and tularemia,influenzae and gram-negative bacteria infection treatment.

Product name	Streptomycin sulfate
Characters	A White or almost white powder,hygroscopic, very soluble in water,practically insoluble in ethanol
Identification	A. TLC-test:Principal spot should be as per ref.standard B. Reaction with ferric chloride:violet colour develops C. Reaction with sodium Hypochlorite:Red colour develops D. Reaction with hydrochloric acid:faint yellow colour develops E. Reaction of sulfates
Assay	758 IU/mg
Specification	BP2018/Ph. Eur. 9.0

 

Product name	Streptomycin sulfate
CAS:	3810-74-0
MF:	C42H84N14O36S3
MW:	1457.38
EINECS:	223-286-0
Streptomycin sulfate is the sulfate form of streptomycin. Streptomycin class antibiotics are produced by the soil-living Actinomyces Streptomyces. Streptomycin is the first emerging drug which has been proven to be an effective chemotherapy drug in treating tuberculosis. This product must be injected intramuscularly which makes it be limited for long-term application. Streptomycin, obtained from Streptomyces, is currently the most effective and also the least toxic antibiotics for application outside the gastrointestinal tract.This product is a kind of fungicides which may be due to its direct effect on the bacterial ribosome, and the resulting effective inhibition of protein synthesis. It is mainly used for treating extracellular (including the cavity) Mycobacterium tuberculosis.