Coadministration na ivermectin, diethylcarbamazine, da albendazole yana tabbatar da amintaccen maganin magunguna.

gabatar:

A cikin ci gaba don shirye-shiryen kiwon lafiyar jama'a, masu bincike sun tabbatar da aminci da tasiri na babban haɗin magunguna na ivermectin, diethylcarbamazine (DEC) da albendazole. Wannan babban ci gaba zai yi tasiri sosai a ƙoƙarin duniya don yaƙar cututtuka daban-daban na wurare masu zafi (NTDs).

baya:

Cututtukan wurare masu zafi da aka yi watsi da su suna shafar fiye da mutane biliyan ɗaya a cikin ƙasashe masu fama da talauci kuma suna haifar da manyan ƙalubale ga lafiyar duniya. Ana amfani da Ivermectin sosai don magance cututtukan cututtuka, gami da makanta kogi, yayin da DEC ke hari filariasis lymphatic. Albendazole yana da tasiri a kan tsutsotsi na hanji. Gudanar da waɗannan magungunan na iya magance yawancin NTDs a lokaci ɗaya, yana sa tsarin kulawa ya fi dacewa da tsada.

Aminci da inganci:

Wani bincike na baya-bayan nan da wata tawagar masu binciken kasa da kasa suka gudanar da nufin tantance lafiyar shan wadannan magunguna guda uku tare. Gwajin ya ƙunshi mahalarta sama da 5,000 a ƙasashe da yawa, gami da waɗanda ke da kamuwa da cuta. Sakamakon binciken ya nuna cewa haɗin gwiwar haɗin gwiwa yana da kyau kuma yana da ƙananan tasiri. Abin lura, abin da ya faru da tsanani na mummunan al'amura sun kasance daidai da waɗanda aka lura lokacin da aka dauki kowane magani shi kadai.

Bugu da ƙari, ingancin haɗuwar ƙwayoyi masu girma yana da ban sha'awa. Mahalarta sun nuna raguwa mai yawa a cikin nauyin ƙwayoyin cuta da ingantattun sakamakon asibiti a cikin nau'ikan cututtukan da ake bi da su. Wannan sakamakon ba wai kawai yana nuna tasirin haɗin gwiwar haɗin gwiwar jiyya ba amma kuma yana ba da ƙarin shaida don yuwuwa da dorewar shirye-shiryen kulawa na NTD.

Tasiri kan lafiyar jama'a:

Nasarar aiwatar da magungunan haɗin gwiwa yana kawo babban bege ga manyan ayyukan jiyya na miyagun ƙwayoyi. Ta hanyar haɗa mahimman magunguna guda uku, waɗannan yunƙurin na iya daidaita ayyuka tare da rage tsada da sarƙaƙƙiyar kayan aiki masu alaƙa da gudanar da tsare-tsaren jiyya daban-daban. Bugu da ƙari, haɓaka inganci da rage tasirin sakamako suna sa wannan hanyar ta shahara sosai, yana tabbatar da ingantaccen yarda da sakamako gabaɗaya.

Manufar kawar da duniya:

Haɗin ivermectin, DEC da albendazole ya yi daidai da taswirar Hukumar Lafiya ta Duniya (WHO) don kawar da NTDs. Manufofin ci gaba mai dorewa (SDGs) suna kira don sarrafawa, kawarwa ko kawar da waɗannan cututtuka ta 2030. Wannan haɗin gwiwar magani yana wakiltar wani muhimmin mataki don cimma waɗannan manufofi, musamman a yankunan da yawancin NTDs suke tare.

mai yiwuwa:

Nasarar wannan binciken yana buɗe hanya don faɗaɗa dabarun haɗin kai. Masu bincike a halin yanzu suna binciken yuwuwar shigar da wasu takamaiman magungunan NTD cikin hanyoyin haɗin gwiwa, irin su praziquantel don schistosomiasis ko azithromycin na trachoma. Waɗannan shirye-shiryen suna nuna himmar al'ummar kimiyya don ci gaba da daidaitawa da haɓaka shirye-shiryen sarrafa NTD.

Kalubale da ƙarshe:

Kodayake haɗin gwiwar ivermectin, DEC, da albendazole yana ba da fa'idodi masu yawa, ƙalubalen sun kasance. Daidaita waɗannan zaɓuɓɓukan jiyya zuwa yankuna daban-daban, tabbatar da samun dama, da shawo kan shingen dabaru zai buƙaci ƙoƙarin haɗin gwiwa tsakanin gwamnatoci, ƙungiyoyin ƙasa da ƙasa, da masu ba da lafiya. Koyaya, yuwuwar haɓaka sakamakon lafiyar jama'a ga biliyoyin mutane ya zarce waɗannan ƙalubalen.

A ƙarshe, nasarar haɗin ivermectin, DEC, da albendazole yana ba da mafita mai amfani kuma mai aminci don babban maganin cututtukan da ba a kula da su ba. Wannan cikakkiyar dabarar tana da babban alƙawari don cimma burin kawar da duniya da kuma nuna himmar ƙungiyar kimiyya don tunkarar ƙalubalen lafiyar jama'a gaba-gaba. Tare da ƙarin bincike da shirye-shiryen da ke gudana, makomar kulawar NTD ta bayyana haske fiye da kowane lokaci.