Vitamin C, wanda kuma aka sani da ascorbic acid, shine muhimmin sinadari mai narkewa da ruwa. Mutane da wasu dabbobi (irin su primates, aladu) sun dogara da bitamin C a cikin samar da abinci mai gina jiki na 'ya'yan itatuwa da kayan marmari (jajayen barkono, lemu, strawberry, broccoli, mango, lemun tsami). An gane yuwuwar rawar da bitamin C ke da shi wajen yin rigakafi da inganta cututtuka a cikin jama'ar likitoci.
Ascorbic acid yana da mahimmanci don amsawar rigakafi. Yana da mahimmanci anti-mai kumburi, immunomodulatory, antioxidant, anti-thrombosis da anti-viral Properties.
Vitamin C da alama yana iya daidaita martanin mai masaukin baki game da matsanancin ciwo na numfashi na coronavirus 2 (SARS-CoV-2). Coronavirus shine sanadin cutar sankara na 2019 (COVID-19), musamman yana cikin mawuyacin hali. A cikin sharhin kwanan nan da aka buga a Preprints *, Patrick Holford et al. An warware rawar bitamin C azaman ƙarin magani don cututtukan numfashi, sepsis da COVID-19.
Wannan labarin ya tattauna yuwuwar rawar da bitamin C ke takawa wajen hana muhimmin mataki na COVID-19, cututtukan cututtukan numfashi da sauran cututtukan kumburi. Ana sa ran ƙarin bitamin C ya zama wakili na rigakafi ko warkewa don COVID-19-gyara rashi da cutar ta haifar, rage damuwa na iskar oxygen, haɓaka samar da interferon da tallafawa tasirin anti-mai kumburi na glucocorticoids.
Don kiyaye matakan plasma na al'ada a cikin manya a 50 μmol / l, adadin bitamin C ga maza shine 90 mg / d kuma na mata 80 mg / d. Wannan ya isa ya hana scurvy (cutar da rashin bitamin C ke haifarwa). Duk da haka, wannan matakin bai isa ba don hana kamuwa da kwayar cutar hoto da damuwa na jiki.
Don haka, Ƙungiyar Gina Jiki ta Swiss ta ba da shawarar ƙara kowane mutum da 200 MG na bitamin C-don cike gibin abinci mai gina jiki na yawan jama'a, musamman ma manya masu shekaru 65 da haihuwa. An tsara wannan ƙarin don ƙarfafa tsarin rigakafi. "
A ƙarƙashin yanayin damuwa na physiological, matakan bitamin C na jikin mutum yana raguwa da sauri. Abubuwan da ke cikin jini na bitamin C na marasa lafiya a asibiti shine ≤11µmol/l, kuma yawancinsu suna fama da matsanancin kamuwa da cutar numfashi, sepsis ko COVID-19 mai tsanani.
Nazarin shari'o'i daban-daban daga ko'ina cikin duniya sun nuna cewa ƙananan matakan bitamin C sun zama ruwan dare a cikin marasa lafiya marasa lafiya marasa lafiya da ke fama da cututtukan numfashi, ciwon huhu, sepsis da COVID-19-mafi kusantar bayanin shine ƙara yawan abinci.
Meta-bincike ya ba da haske game da abubuwan da ke biyowa: 1) Ƙarin Vitamin C na iya rage haɗarin ciwon huhu sosai, 2) Binciken da aka yi bayan mutuwa bayan mutuwar COVID-19 ya nuna ciwon huhu na biyu, da 3) Rashin bitamin C ya haifar da jimillar yawan jama'a ciwon huhu 62%.
Vitamin C yana da tasiri mai mahimmanci na homeostatic azaman antioxidant. An san cewa yana da aikin kashe ƙwayoyin cuta kai tsaye kuma yana iya haɓaka samar da interferon. Yana da hanyoyin tasiri a cikin tsarin rigakafi na asali da na daidaitawa. Vitamin C yana rage nau'in oxygen mai aiki (ROS) da kumburi ta hanyar rage kunna NF-κB.
SARS-CoV-2-ƙasa-yana daidaita maganganun nau'in 1 interferon (babban tsarin kariya na mai masaukin baki), yayin da ascorbic acid yana daidaita waɗannan mahimman furotin tsaro na rundunar.
Muhimmin lokaci na COVID-19 (yawanci lokaci mai kisa) yana faruwa a lokacin haɓakar cytokines masu kumburi masu inganci da chemokines. Wannan ya haifar da ci gaba da gazawar gabobin jiki. Yana da alaƙa da ƙaura da tarawa na neutrophils a cikin huhu interstitium da bronchoalveolar cavity, na karshen shine mabuɗin mahimmanci na ARDS (Cutar Ciwon Ciwon Hankali).
Matsakaicin adadin ascorbic acid a cikin glandar adrenal da glandon pituitary ya ninka sau uku zuwa goma fiye da kowane gabobin. Ƙarƙashin damuwa na jiki (ACTH stimulating) yanayi ciki har da bayyanar cututtuka, an saki bitamin C daga adrenal cortex, yana haifar da matakan plasma ya karu sau biyar.
Vitamin C na iya haɓaka samar da cortisol, kuma yana haɓaka tasirin anti-mai kumburi da ƙwayoyin endothelial na glucocorticoids. Exogenous glucocorticoid steroids sune kawai magungunan da aka tabbatar don magance COVID-19. Vitamin C wani nau'i ne na hormone mai haɓakawa da yawa, wanda ke taka muhimmiyar rawa wajen daidaitawa da amsawar damuwa na adrenal cortex (musamman sepsis) da kuma kare endothelium daga lalacewar oxidative.
Yin la'akari da tasirin bitamin C akan mura-rage tsawon lokaci, tsanani da kuma yawan shan bitamin C na sanyi na iya rage sauye-sauye daga kamuwa da cuta mai laushi zuwa muhimmin lokacin COVID-19.
An lura cewa karin bitamin C na iya rage tsawon zama a cikin ICU, rage lokacin samun iska na marasa lafiya masu fama da COVID-19, da rage yawan mace-mace na masu cutar sepsis waɗanda ke buƙatar magani tare da vasopressors.
Yin la'akari da yanayi daban-daban na zawo, duwatsun koda da gazawar koda a lokacin manyan allurai, marubutan sun tattauna lafiyar lafiyar baki da na jini na bitamin C. Ana iya ba da shawarar babban adadin 2-8 g / rana. a hankali kauce wa yawan allurai ga mutanen da ke da tarihin ciwon koda ko ciwon koda). Saboda yana da ruwa mai narkewa, ana iya fitar da shi a cikin 'yan sa'o'i kadan, don haka yawan adadin yana da mahimmanci don kula da isasshen matakan jini yayin kamuwa da cuta.
Kamar yadda muka sani, bitamin C na iya hana kamuwa da cuta da inganta rigakafi. Musamman game da muhimmin mataki na COVID-19, bitamin C yana taka muhimmiyar rawa. Yana rage-kayyade guguwar cytokine, yana kare endothelium daga lalacewar oxidative, yana taka muhimmiyar rawa wajen gyaran nama, kuma yana inganta amsawar rigakafi ga kamuwa da cuta.
Marubucin ya ba da shawarar cewa ya kamata a ƙara ƙarin abubuwan bitamin C kowace rana don ƙarfafa ƙungiyoyi masu haɗari waɗanda ke da yawan mace-macen COVID-19 da ƙarancin bitamin C. Ya kamata a koyaushe su tabbatar da cewa bitamin C ya isa kuma ƙara yawan adadin lokacin da cutar ta kamu da cutar, har zuwa 6-8 g / rana. Yawancin nazarin rukunin rukunin bitamin C da suka dogara da kashi suna gudana a duk duniya don tabbatar da rawar da take takawa wajen kawar da COVID-19 da kuma fahimtar rawar da take takawa a matsayin yuwuwar warkewa.
Preprints za su buga rahotannin kimiyya na farko waɗanda ba a yi bitar takwarorinsu ba, sabili da haka bai kamata a yi la'akari da ƙaƙƙarlla ba, jagorar aikin asibiti/ halaye masu alaƙa da lafiya ko ɗaukar takamaiman bayani.
Tags: m na numfashi wahala ciwo, anti-mai kumburi, antioxidant, ascorbic acid, jini, broccoli, chemokine, coronavirus, coronavirus cutar COVID-19, corticosteroid, cortisol, cytokine, cytokine, zawo, mita, Glucocorticoids, hormones, rigakafi da martani, rigakafi tsarin, kumburi, interstitial, koda, koda cuta, koda gazawar, mace-mace, abinci mai gina jiki, oxidative danniya, annoba, ciwon huhu, numfashi, SARS-CoV-2, scurvy , Sepsis, m m cututtuka, m numfashi ciwo, strawberry, danniya, ciwo, kayan lambu, cutar, bitamin C
Ramya tana da PhD. Pune National Chemical Laboratory (CSIR-NCL) ya sami PhD a Biotechnology. Ayyukanta sun haɗa da aikin nanoparticles tare da kwayoyin halitta daban-daban na sha'awar ilimin halitta, nazarin tsarin amsawa da gina aikace-aikace masu amfani.
Dwivedi, Ramya. (2020, Oktoba 23). Vitamin C da COVID-19: bita. Labaran likitanci. An dawo daga https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ranar 12 ga Nuwamba, 2020.
Dwivedi, Ramya. "Vitamin C da COVID-19: Bita." Labaran likitanci. Nuwamba 12, 2020.
Dwivedi, Ramya. "Vitamin C da COVID-19: Bita." Labaran likitanci. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (An shiga ranar 12 ga Nuwamba, 2020).
Dwivedi, Ramya. 2020. "Vitamin C da COVID-19: Bita." News-Medical, an yi lilo a ranar 12 ga Nuwamba, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
A cikin wannan hirar, Farfesa Paul Tesar da Kevin Allan sun buga labarai ga mujallun likitanci game da yadda ƙarancin iskar oxygen ke lalata kwakwalwa.
A cikin wannan hira, Dr. Jiang Yigang ya tattauna tsarin ACRBiosystems da kokarinsa na yakar COVID-19 da gano alluran rigakafi.
A cikin wannan hira, News-Medical sun tattauna ci gaba da halayyar ƙwayoyin rigakafi na monoclonal tare da David Apiyo, babban manajan aikace-aikace a Sartorius AG.
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