Ua hōʻike ʻia kahi noiʻi Denemaka no nā poʻe maʻi me ka exacerbations acute o ka maʻi obstructive pulmonary maʻi (COPD), ʻoi aku ka maikaʻi o ka amoxicillin wale nō ma mua o ka amoxicillin i hui pū ʻia me kahi lāʻau antibiotic, clavulanic acid.
ʻO ka haʻawina i kapa ʻia ʻo "Antibiotic Therapy in Acute Exacerbations of COPD: Patient Outcomes of Amoxicillin and Amoxicillin/Clavulanic Acid-Data mai 43,636 Outpatients" i paʻi ʻia ma ka Journal of Respiratory Research.
ʻO kahi exacerbation koʻikoʻi o COPD kahi hanana kahi e hoʻomāhuahua koke ai nā hōʻailona o ka mea maʻi. Ma muli o ka pili pinepine ʻana o kēia mau exacerbations i nā maʻi bacterial, ʻo ka mālama ʻana me nā lāʻau antibiotic (nā lāʻau e pepehi ai i ka maʻi bacteria) he ʻāpana o ka maʻamau o ka mālama.
Ma Denmark, aia ʻelua mau lāʻau antibiotic maʻamau i hiki ke hoʻohana ʻia e mālama i nā exacerbations. ʻO kekahi he 750 mg amoxicillin ʻekolu manawa i ka lā, a ʻo kekahi he 500 mg amoxicillin me 125 mg clavulanic acid, ʻekolu mau manawa i ka lā.
ʻO Amoxicillin a me clavulanic acid nā beta-lactams, he mau lāʻau lapaʻau e hana ana ma ke keakea ʻana i ka hana ʻana o nā paia cell bacteria, a laila pepehi i ka bacteria.
ʻO ke kumu kumu o ka hoʻohui ʻana i kēia mau lāʻau lapaʻau ʻelua ʻo ia ka hopena o ka waikawa clavulanic e kūʻē i nā ʻano bacteria like ʻole. Eia nō naʻe, ʻo ka mālama ʻana me ka amoxicillin wale nō, ʻo ia ka mea hiki ke hāʻawi ʻia i hoʻokahi lāʻau antibiotic ma ke ʻano kiʻekiʻe, hiki ke pepehi i ka maʻi bacteria.
I kēia manawa, ua hoʻohālikelike pololei kahi hui o nā mea noiʻi Denemaka i nā hopena o kēia mau regimen ʻelua no ka mālama ʻana i nā exacerbations acute o COPD.
Ua hoʻohana ka poʻe noiʻi i ka ʻikepili mai ka Danish COPD registry, i hui pū ʻia me ka ʻikepili mai nā papa inoa aupuni ʻē aʻe, e ʻike i nā maʻi 43,639 me nā kūlana aggravated i loaʻa i kekahi o nā koho ʻelua i kālailai ʻia. ʻO ka mea kūikawā, 12,915 poʻe i lawe i ka amoxicillin wale nō a 30,721 poʻe i lawe i nā lāʻau hui. He mea pono e hoʻomaopopo ʻaʻole i mālama ʻia kekahi o nā mea maʻi i ka haukapila ma muli o ka exacerbation COPD, e hōʻike ana ʻaʻole koʻikoʻi ka hoʻouka ʻana.
Ke hoʻohālikelike ʻia me ka hui pū ʻana o ka amoxicillin a me ka clavulanic acid, hiki i ka mālama ʻana me ka amoxicillin wale nō ke hōʻemi i ka hopena o ka maʻi maʻi pili i ka maʻi pneumonia a i ʻole ke kumu o ka make ma 40% ma hope o 30 mau lā. Hoʻopili pū ʻia ʻo Amoxicillin wale nō me ka hōʻemi ʻana o 10% i ka pilikia o ka halemai non-pneumonia a i ʻole ka make a me ka hōʻemi ʻana o 20% i ka hopena o nā kumu āpau a i ʻole ka make.
No kēia mau ana a pau, he koʻikoʻi ka ʻokoʻa ma waena o nā lapaʻau ʻelua. Loaʻa maʻamau ka ʻikepili helu ʻē aʻe i nā hopena kūlike.
Ua kākau nā mea noiʻi: "Ua ʻike mākou i ka hoʻohālikelike ʻia me AMC [amoxicillin plus clavulanic acid], ʻo AECOPD [COPD exacerbation] nā maʻi maʻi i mālama ʻia me AMX [amoxicillin wale nō] i ka pilikia o ka hale maʻi a i ʻole ka make me ka pneumonia i loko o 30 mau lā.
Manaʻo ka hui ʻo kekahi kumu kumu o kēia hopena ʻo ka ʻokoʻa o ka dosage ma waena o nā regimen antibiotic ʻelua.
"I ka lawelawe ʻana i ka maʻi like ʻole, ʻaʻole i emi iki ka AMC [hui] ma mua o AMX [amoxicillin wale nō]," i kākau ai lākou.
Ma ke ʻano holoʻokoʻa, "kākoʻo ka loiloi i ka hoʻohana ʻana iā AMX ma ke ʻano he lāʻau antibiotic i makemake ʻia no ka poʻe maʻi ma waho me AECOPD," i hoʻopau ai nā mea noiʻi no ka mea "ʻo ka hoʻohui ʻana o ka clavulanic acid i ka amoxicillin ʻaʻohe mea pili i nā hopena maikaʻi aʻe."
Wahi a nā mea noiʻi, ʻo ka palena nui o ke aʻo ʻana ʻo ka pilikia o ka huikau ma muli o nā hōʻailona-ma nā huaʻōlelo ʻē aʻe, ʻoi aku ka maikaʻi o ka poʻe i loko o ke kūlana ʻilihune. ʻOiai ke hoʻāʻo nei ka ʻikepili helu a ka poʻe noiʻi e wehewehe i kēia kumu, hiki nō ke wehewehe i nā ʻokoʻa o ka mālama ʻana i kekahi o nā hopena.
ʻO kēia pūnaewele kahi pūnaewele nūhou a me ka ʻike e pili ana i ka maʻi. ʻAʻole ia e hāʻawi i ka ʻōlelo aʻoaʻo lapaʻau, ka maʻi a i ʻole ka lāʻau lapaʻau. ʻAʻole kēia maʻiʻo he pani no ka ʻōlelo aʻoaʻo lapaʻau ʻoihana, ka maʻi a i ʻole ka mālama ʻana. Inā he mau nīnau kāu e pili ana i nā kūlana olakino, e ʻimi mau i ka ʻōlelo aʻoaʻo a kāu kauka a i ʻole kekahi mea mālama ola olakino. Mai haʻalele i ka ʻōlelo aʻo lapaʻau ʻoihana a hoʻopaneʻe paha i ka ʻimi ʻana i ka ʻōlelo aʻoaʻo no ka mea āu i heluhelu ai ma kēia pūnaewele.