No ʻelua mau makahiki, ua hāʻawi ʻia ʻo albendazole i kahi papahana nui no ka mālama ʻana i ka lymphatic filariasis. Ua nānā ʻia kahi loiloi Cochrane hou i ka pono o ka albendazole i ka lymphatic filariasis.
ʻO ka Lymphatic filariasis kahi maʻi i lawe ʻia e ka makika i loaʻa maʻamau i nā ʻāina wela a me nā subtropical i hoʻokumu ʻia e ka maʻi filariasis parasitic. Ma hope o ka maʻi ʻana, ulu nā ʻōhua a lilo i mau mākua a male e hana i microfilariae (mf). A laila ʻohi ʻia ka MF e nā makika i ka wā e hānai ana i ke koko, a hiki ke hoʻoili ʻia ka maʻi i kekahi kanaka.
Hiki ke ʻike ʻia ka maʻi ma o nā hoʻāʻo ʻana no ka MF kaʻahele (microfilaraemia) a i ʻole nā ​​​​antigens parasite (antigenemia) a i ʻole ma ka ʻike ʻana i nā ilo makua ola e ka ultrasound.
Paipai ka World Health Organization (WHO) i ka mālama nui ʻana i ka heluna kanaka a pau i kēlā me kēia makahiki no ʻelima mau makahiki. ʻO ke kumu o ka mālama ʻana he hui pū ʻana o nā lāʻau lapaʻau ʻelua: albendazole a me ka microfilaricidal (antimalarial) drug diethylcarbamazine (DEC) a ivermectin.
Manaʻo ʻia ʻo Albendazole i kēlā me kēia hapalua makahiki ma nā wahi e pili pū ana ka loiasis, a ʻaʻole pono e hoʻohana ʻia ka DEC a i ʻole ivermectin ma muli o ka pilikia o nā hopena koʻikoʻi.
Hoʻopau koke ʻo ivermectin a me DEK i nā maʻi mf a hiki ke pale i ko lākou hoʻi hou ʻana. Eia nō naʻe, e hoʻomaka hou ka hana mf ma muli o ka liʻiliʻi o ka ʻike ʻana i nā pākeke. Ua noʻonoʻo ʻia ʻo Albendazole no ka mālama ʻana i ka filariasis lymphatic no ka mea ua hōʻike ʻia kahi noiʻi ʻana i nā hopena kiʻekiʻe i mālama ʻia i nā pule he nui i hopena i nā hopena koʻikoʻi e hōʻike ana i ka make ʻana o nā ilo makua.
Ua hōʻike ʻia kahi hōʻike ʻike ʻole o ka kūkākūkā ʻana o WHO he hopena pepehi a fungicidal paha ka albendazole i nā pākeke. Ma 2000, hoʻomaka ʻo GSK e hāʻawi i ka albendazole i ka Lymphatic Filariasis Treatment Program.
Ua nānā ʻia nā hoʻāʻo hoʻāʻo ʻokoʻa (RCTs) i ka pono a me ka palekana o ka albendazole wale nō a i hui pū ʻia me ivermectin a i ʻole DEC. Ua ukali ʻia kēia e kekahi mau loiloi ʻōnaehana o nā RCT a me nā ʻikepili nānā, akā ʻaʻole maopopo inā he pōmaikaʻi ʻo albendazole i ka lymphatic filariasis.
Ma muli o kēia, ua hoʻoponopono hou ʻia kahi loiloi Cochrane i paʻi ʻia ma 2005 e loiloi i ka hopena o ka albendazole ma luna o nā heluna a me nā kaiāulu me ka lymphatic filariasis.