No ʻelua mau makahiki, ua hāʻawi ʻia ʻo albendazole i kahi papahana nui no ka mālama ʻana i ka lymphatic filariasis. Ua nānā ʻia kahi loiloi Cochrane hou i ka pono o ka albendazole i ka mālama ʻana i ka lymphatic filariasis.
ʻO ka lymphatic filariasis kahi maʻi maʻamau i nā ʻāina wela a me nā ʻāina subtropical, lawe ʻia e nā makika a ma muli o ka maʻi filariasis parasitic. Ma hope o ka maʻi ʻana, ulu nā ʻōhua a lilo i mau mākua a male e hana i microfilariae (MF). Lawe ka makika i ka MF i ka wā e hānai ana i ke koko, a hiki ke hoʻoili ʻia ka maʻi i kekahi kanaka.
Hiki ke ʻike ʻia ka maʻi maʻi ma o ka hoʻāʻo ʻana no ka MF kaʻahele (microfilamentemia) a i ʻole nā ​​​​antigens parasite (antigenemia) a i ʻole ma ka ʻike ʻana i nā ilo makua ola e ka ultrasonography.
Paipai ka World Health Organization (WHO) i ka mālama nui ʻana i ka heluna kanaka a pau i kēlā me kēia makahiki no ʻelima mau makahiki. ʻO ke kumu o ka mālama ʻana he hui pū ʻana o nā lāʻau lapaʻau ʻelua: albendazole a me microfilaricidal (antifilariasis) drug diethylcarmazine (DEC) a ivermectin.
ʻO Albendazole wale nō ka mea i manaʻo ʻia no ka hoʻohana ʻana i ka hapalua makahiki ma nā wahi e pili pū ana ka maʻi Roa, kahi e hoʻohana ʻole ʻia ai ka DEC a i ʻole ivermectin ma muli o ka pilikia o nā hopena koʻikoʻi.
Hoʻopau koke ʻo ivermectin a me DEC i ka maʻi MF a hoʻopaʻa i kona hoʻi hou ʻana. Eia nō naʻe, e hoʻomaka hou ka hana MF ma muli o ka liʻiliʻi o ka ʻike ʻana i nā pākeke. Ua noʻonoʻo ʻia ʻo Albendazole no ka mālama ʻana i ka lymphatic filariasis ma hope o kahi noiʻi i hōʻike ʻia ʻo ka nui o nā kumu i hāʻawi ʻia i nā pule he nui i alakaʻi i nā hopena koʻikoʻi e hōʻike ana i ka make ʻana o nā ilo makua.
Ma hope mai ua hōʻike ʻia kahi kūkākūkā maʻamau o WHO he hana pepehi a sterilizing paha a albendazole i nā ilo makua. I ka makahiki 2000, ua hoʻomaka ʻo GlaxoSmithKline e hāʻawi i ka albendazole i nā papahana e mālama i ka lymphatic filariasis.
Ua nānā ʻia nā hoʻāʻo hoʻāʻo ʻokoʻa (RCT) i ka pono a me ka palekana o ka albendazole wale nō a i hui pū ʻia me ivermectin a i ʻole DEC. Ma hope mai, ua nui nā loiloi ʻōnaehana o nā ho'āʻo hoʻokele randomized a me nā ʻikepili nānā, akā ʻaʻole maopopo inā he pōmaikaʻi ʻo albendazole i ka lymphatic filariasis.
Ma muli o kēia, ua hōʻano hou ʻia kahi loiloi Cochrane i paʻi ʻia ma 2005 e loiloi i ka hopena o ka albendazole i nā maʻi a me nā kaiāulu me ka lymphatic filariasis.
ʻO nā loiloi Cochrane nā loiloi ʻōnaehana e manaʻo e ʻike, loiloi, a hōʻuluʻulu i nā hōʻike empirical āpau e kū ana i nā pae i koho mua ʻia e pane i kahi nīnau noiʻi. Hoʻopau hou ʻia nā loiloi Cochrane i ka loaʻa ʻana o ka ʻikepili hou.
ʻO ke ala ʻo Cochrane e hōʻemi i ka manaʻo ʻino i ke kaʻina loiloi. Hoʻopili kēia i ka hoʻohana ʻana i nā mea hana e loiloi ai i ka pilikia o ka hoʻohālikelike i nā hoʻāʻo pākahi a nānā i ka ʻoiaʻiʻo (a i ʻole ka maikaʻi) o nā hōʻike no kēlā me kēia hopena.
Ua hoʻopuka ʻia kahi ʻōlelo Cochrane hou "Albendazole wale nō a i hui pū ʻia me nā microfilaricidal agents in lymphatic filariasis" i paʻi ʻia ma Ianuali 2019 e ka Cochrane Infectious Diseases Group a me ka COUNTDOWN Consortium.
ʻO nā hopena o ka hoihoi e pili ana i ka hiki ke hoʻouna ʻia (ka prevalence a me ka nui o ka MF), nā hōʻailona maʻi ilo makua (ka nui a me ka nui o ka antigenemia, a me ka ʻike ultrasound o nā ilo makua), a me nā ana o nā hanana ʻino.
Ua hoʻāʻo nā mea kākau e hoʻohana i kahi huli uila e ʻike i nā hoʻokolohua kūpono āpau a hiki i Ianuali 2018, me ka ʻole o ka ʻōlelo a i ʻole ke kūlana paʻi. ʻElua mau mea kākau i loiloi kūʻokoʻa i nā haʻawina no ka hoʻopili ʻana, loiloi i ka pilikia o ka bias, a me ka unuhi ʻana i ka ʻikepili hoʻokolokolo.
Aia ka loiloi i nā hoʻokolohua 13 me ka huina o 8713 mau mea komo. Ua hana ʻia kahi meta-analysis o ka laha o nā parasites a me nā hopena ʻaoʻao e ana i nā hopena lapaʻau. E hoʻomākaukau i nā papa no ka hoʻopaʻa ʻana i nā hopena pāpaʻi, no ka mea ʻaʻole hiki ke hoʻohui ʻia ka ʻikepili.
Ua ʻike nā mea kākau ʻo albendazole wale nō a i hui pū ʻia me nā microfilaricides i liʻiliʻi i ka hopena o ka MF ma waena o ʻelua pule a me 12 mau mahina ma hope o ka mālama ʻana (nā hōʻike kiʻekiʻe kiʻekiʻe).
ʻAʻole lākou i ʻike inā he hopena ma ka mf density ma 1-6 mahina (hōʻike haʻahaʻa haʻahaʻa loa) a i ʻole ma 12 mau mahina (hōʻike haʻahaʻa haʻahaʻa loa).
ʻO Albendazole wale nō a i hui pū ʻia me nā microfilaricides ʻaʻohe hopena liʻiliʻi i ka prevalence o antigenemia ma luna o 6-12 mahina (nā hōʻike kiʻekiʻe kiʻekiʻe).
ʻAʻole i ʻike nā mea kākau inā he hopena i ka density antigen ma waena o 6 a me 12 mau makahiki (nā hōʻike haʻahaʻa haʻahaʻa loa). Hoʻohui ʻia ʻo Albendazole i nā microfilaricides ʻaʻole paha he hopena liʻiliʻi i ka laha ʻana o nā ilo makua i ʻike ʻia e ka ultrasound ma 12 mahina (nā hōʻike haʻahaʻa haʻahaʻa).
Ke hoʻohana wale ʻia a hui pū ʻia paha, ʻaʻohe hopena liʻiliʻi o ka albendazole i ka helu o ka poʻe e hōʻike ana i nā hanana ʻino (nā hōʻike kiʻekiʻe).
Ua loaʻa i ka loiloi nā hōʻike kūpono ʻo albendazole, hoʻokahi a i hui pū ʻia me nā microfilaricides, he liʻiliʻi a ʻaʻohe hopena i ka hoʻopau piha ʻana i nā microfilariae a i ʻole helminth makua ma loko o 12 mau mahina o ka mālama ʻana.
ʻOiai ʻo kēia lāʻau lapaʻau he ʻāpana o ke kulekele koʻikoʻi, a ʻo ka World Health Organization i kēia manawa ke paipai nei i kahi regimen lāʻau ʻekolu, ʻaʻole paha e hoʻomau ka poʻe noiʻi e loiloi i ka albendazole i hui pū me DEC a ivermectin.
Eia naʻe, ma nā wahi e pili ana i ka Roa, ʻōlelo ʻia ʻo albendazole wale nō. No laila, ʻo ka hoʻomaopopo ʻana i ka hana ʻana o ka lāʻau lapaʻau i kēia mau kaiāulu e noho mau ana i ka noiʻi mua.
Hiki ke loa'a ka hopena nui i nā polokalamu ho'opau filariasis nui me ka manawa pōkole. ʻO kekahi o kēia mau lāʻau i kēia manawa i ka hoʻomohala preclinical a ua paʻi ʻia ma kahi blog BugBitten hou.
Ma ka hoʻomau ʻana i ka hoʻohana ʻana i kēia pūnaewele, ua ʻae ʻoe i kā mākou Kūlana o ka hoʻohana, alakaʻi kaiaulu, ʻōlelo pilikino a me nā kulekele kuki.