ʻO ka Vitamin C, ka mea i kapa ʻia ʻo ascorbic acid, he meaʻai pono e hoʻoheheʻe ʻia i ka wai. Ke hilinaʻi nei nā kānaka a me nā holoholona ʻē aʻe (e like me nā primates, puaʻa) i ka huaora C i ka lako meaʻai o nā huaʻai a me nā mea kanu (ʻulaʻula, ʻalani, strawberry, broccoli, mango, lemon). Ua ʻike ʻia ke kuleana kūpono o ka huaora C i ka pale ʻana a me ka hoʻomaikaʻi ʻana i nā maʻi maʻi.
He mea nui ka ascorbic acid no ka pane ʻana o ke kino. He mea koʻikoʻi ka anti-inflammatory, immunomodulatory, antioxidant, anti-thrombosis a me nā waiwai anti-viral.
Me he mea lā e hiki ai i ka Vitamin C ke hoʻoponopono i ka pane ʻana o ka mea hoʻokipa i ka maʻi maʻi hanu maʻi maʻi coronavirus 2 (SARS-CoV-2). ʻO Coronavirus ke kumu kumu o ka maʻi maʻi coronavirus 2019 (COVID-19), ʻoiai aia i kahi wā koʻikoʻi. Ma kahi ʻōlelo hou i paʻi ʻia ma Preprints*, ʻo Patrick Holford et al. Hoʻoholo i ka hana o ka huaora C ma ke ʻano he kōkua kōkua no nā maʻi hanu, sepsis a me COVID-19.
Kūkākūkā kēia ʻatikala i ke kuleana kūpono o ka huaora C i ka pale ʻana i ke kūlana koʻikoʻi o COVID-19, nā maʻi hanu a me nā maʻi ʻē aʻe. Manaʻo ʻia ka hoʻohui ʻana i ka Vitamin C he mea pale a i ʻole therapeutic agent no ka hoʻoponopono ʻana o COVID-19 i nā hemahema i hoʻokumu ʻia e ka maʻi, e hōʻemi ana i ke kaumaha oxidative, hoʻonui i ka hana interferon a me ke kākoʻo ʻana i nā hopena anti-inflammatory o glucocorticoids.
No ka mālama ʻana i nā pae plasma maʻamau i nā pākeke ma 50 µmol/l, ʻo ka nui o ka huaora C no nā kāne he 90 mg/d a no nā wahine he 80 mg/d. Ua lawa kēia no ka pale ʻana i ka scurvy (he maʻi i hoʻokumu ʻia e ka nele o ka huaora C). Eia naʻe, ʻaʻole lawa kēia pae e pale i ka hoʻolaha ʻana i ka maʻi viral a me ke kaumaha physiological.
No laila, paipai ka Swiss Nutrition Society e hoʻonui i kēlā me kēia kanaka me 200 mg o ka huaora C-e hoʻopiha i ka ʻai ʻai o ka lehulehu ākea, ʻoi aku ka nui o nā pākeke 65 mau makahiki a keu. Hoʻolālā ʻia kēia mea hoʻohui e hoʻoikaika i ka ʻōnaehana pale. "
Ma lalo o nā kūlana koʻikoʻi physiological, hāʻule koke nā pae serum vitamin C kanaka. ʻO ≤11µmol/l ka nui o ka vitamina C o nā maʻi maʻi maʻi, a ʻo ka hapa nui o lākou e loaʻa i ka maʻi hanu, sepsis a i ʻole COVID-19 koʻikoʻi.
ʻO nā haʻawina like ʻole mai ka honua holoʻokoʻa e hōʻike ana he haʻahaʻa haʻahaʻa ka nui o ka vitamina C i nā maʻi maʻi maʻi maʻi me nā maʻi hanu, pneumonia, sepsis a me COVID-19-ʻo ka wehewehe nui loa ka hoʻonui ʻana i ka ʻai metabolic.
Ua hōʻike ka meta-analysis i kēia mau ʻike: 1) Hiki i ka hoʻohui ʻana i ka Vitamin C ke hōʻemi nui i ka pilikia o ka maʻi pneumonia, 2) ʻO nā noiʻi post-mortem ma hope o ka make ʻana mai COVID-19 i hōʻike i ka maʻi maʻi maʻi lua, a 3) ʻO ka nele o ka Vitamin C i helu ʻia no ka huina o ka heluna kanaka pneumonia 62%.
He hopena homeostatic koʻikoʻi ka Vitamin C ma ke ʻano he antioxidant. Ua ʻike ʻia he hana pepehi kanaka pololei a hiki ke hoʻonui i ka hana o interferon. Loaʻa iā ia nā hana effector i loko o nā ʻōnaehana immune innate a adaptive. Hoʻemi ka Vitamin C i nā ʻano oxygen reactive (ROS) a me ka mumū ma ka hōʻemi ʻana i ka hoʻāla ʻana o NF-κB.
Hoʻoponopono ʻo SARS-CoV-2 i ka hōʻike ʻana o ka interferon type 1 (ke kumu pale antiviral nui o ka host), aʻo ka ascorbic acid e hoʻoponopono i kēia mau protein pale pale koʻikoʻi.
ʻO ka manawa koʻikoʻi o COVID-19 (ʻo ka manawa maʻamau ka manawa make) i ka wā o ka hana nui ʻana o nā cytokines pro-inflammatory kūpono a me nā chemokines. Ua alakaʻi kēia i ka hoʻomohala ʻana i nā hemahema o ke kino. E pili ana i ka neʻe ʻana a me ka hōʻiliʻili ʻana o nā neutrophils i loko o ka puhaka interstitium a me ka bronchoalveolar cavity, ʻo ia ka mea e hoʻoholo ai i ka ARDS (Acute Respiratory Distress Syndrome).
ʻO ka neʻe ʻana o ka waikawa ascorbic i loko o nā ʻeleʻele adrenal a me ka pituitary gland he ʻekolu a ʻumi mau manawa kiʻekiʻe ma mua o nā mea ʻē aʻe. Ma lalo o ke koʻikoʻi physiological (ACTH stimulation) nā kūlana me ka hoʻolaha ʻana i ka maʻi viral, hoʻokuʻu ʻia ka huaora C mai ka cortex adrenal, e hoʻonui ai i nā pae plasma i ʻelima mau manawa.
Hiki i ka Vitamin C ke hoʻonui i ka hana ʻana o cortisol, a hoʻonui i nā hopena pale anti-inflammatory a me endothelial cell o glucocorticoids. ʻO nā steroids exogenous glucocorticoid wale nō nā lāʻau lapaʻau i hōʻoia ʻia e mālama i ka COVID-19. ʻO ka Vitamin C he hormone hoʻoulu nui i ka hopena, he hana koʻikoʻi ia i ka hoʻoponopono ʻana i ka pane koʻikoʻi adrenal cortex (ʻoi aku ka sepsis) a me ka pale ʻana i ka endothelium mai ka pōʻino oxidative.
No ka noʻonoʻo ʻana i ka hopena o ka huaora C ma ke anu-e hoʻemi i ka lōʻihi, ka paʻakikī a me ka pinepine o ka lawe ʻana i ke anu-ʻo ka huaora C hiki ke hōʻemi i ka hoʻololi ʻana mai ka maʻi maʻi i ka manawa koʻikoʻi o COVID-19.
Ua ʻike ʻia ʻo ka hoʻohui ʻana i ka vitamina C hiki ke hoʻopōkole i ka lōʻihi o ka noho ʻana ma ka ICU, e hoʻopōkole i ka manawa hoʻomaha o nā maʻi maʻi koʻikoʻi me COVID-19, a hoʻemi i ka nui o ka make o nā maʻi maʻi sepsis e koi ana i ka mālama ʻana me nā vasopressors.
I ka noʻonoʻo ʻana i nā ʻano ʻano like ʻole o ka maʻi maʻi, nā pōhaku ʻāʻī a me ka hōʻino ʻole o ka renal i ka wā kiʻekiʻe, ua kūkākūkā nā mea kākau i ka palekana o ka hoʻokele waha a me ka intravenous o ka vitamina C. Hiki ke ʻōlelo ʻia kahi maʻi kiʻekiʻe pōkole palekana o 2-8 g / lā ( pale akahele i ka nui no ka poe me ka moolelo o na pohaku puupaa a i ole ma'i puupaa). No ka mea hiki ke hoʻoheheʻe ʻia i loko o kekahi mau hola, no laila he mea nui ka nui o ka dosage e mālama i nā pae koko i ka wā o ka maʻi maʻi.
E like me kā mākou e ʻike ai, hiki i ka huaora C ke pale i ka maʻi a hoʻomaikaʻi i ka pane ʻana i ka pale. E pili ana i ke kūlana koʻikoʻi o COVID-19, he hana koʻikoʻi ka vitamina C. Hoʻoponopono ia i ka ʻino cytokine, pale i ka endothelium mai ka pōʻino oxidative, hana nui i ka hoʻoponopono ʻana i ka ʻiʻo, a hoʻomaikaʻi i ka pane ʻana i ka maʻi.
Manaʻo ka mea kākau e hoʻohui ʻia nā mea hoʻohui huaʻai C i kēlā me kēia lā e paipai i nā pūʻulu kiʻekiʻe me ka make COVID-19 kiʻekiʻe a me ka hemahema o ka huaora C. Pono lākou e hōʻoia i ka lawa o ka huaora C a hoʻonui i ka nui i ka wā i loaʻa ai ka maʻi maʻi, a hiki i ka 6-8 g / lā. Ke hoʻomau nei ka nui o nā haʻawina cohort vitamin C e hilinaʻi nei i ka honua holoʻokoʻa e hōʻoia i kāna kuleana i ka hoʻomaha ʻana i ka COVID-19 a e hoʻomaopopo maikaʻi i kāna kuleana ma ke ʻano he therapeutic.
E hoʻopuka nā Preprints i nā hōʻike ʻepekema mua ʻaʻole i nānā ʻia e nā hoa, a no laila ʻaʻole pono e manaʻo ʻia he ʻoiaʻiʻo, alakaʻi i ka hana lapaʻau/nā ʻano pili i ke olakino a i ʻole i manaʻo ʻia he ʻike maopopo.
Tags: acute respiratory distress syndrome, anti-inflammatory, antioxidant, ascorbic acid, koko, broccoli, chemokine, coronavirus, coronavirus maʻi COVID-19, corticosteroid, cortisol, cytokine, cytokine, diarrhea, frequency, Glucocorticoids, hormones, immune response, immune ʻōnaehana, ʻulaʻula, interstitial, kidney, maʻi maʻi maʻi, hāʻule ʻole, make, meaʻai, koʻikoʻi oxidative, maʻi maʻi, pneumonia, hanu, SARS-CoV-2, scurvy , Sepsis, maʻi hanu ʻeha koʻikoʻi, maʻi hanu koʻikoʻi koʻikoʻi, strawberry, stress, maʻi, mea kanu, virus, vitamina C
Loaʻa iā Ramya kahi PhD. Ua loaʻa iā Pune National Chemical Laboratory (CSIR-NCL) kahi PhD i ka Biotechnology. Loaʻa kāna hana i ka hana ʻana i nā nanoparticles me nā molekole like ʻole o ka hoihoi olaola, ke aʻo ʻana i nā ʻōnaehana hopena a me ke kūkulu ʻana i nā noi pono.
Dwivedi, Ramya. (2020, ʻOkakopa 23). Vitamin C a me COVID-19: He loiloi. Nūhou lāʻau lapaʻau. Ua kiʻi ʻia mai https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ma Nowemapa 12, 2020.
Dwivedi, Ramya. "Vitamin C a me COVID-19: He loiloi." Nūhou lāʻau lapaʻau. Nowemapa 12, 2020. .
Dwivedi, Ramya. "Vitamin C a me COVID-19: He loiloi." Nūhou lāʻau lapaʻau. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Ua kiʻi ʻia ma Nowemapa 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C a me COVID-19: He Manaʻo." Nūhou-Lapaʻau, nānā ʻia ma Nowemapa 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
I loko o kēia nīnauele, ua paʻi ʻo Polofesa Paul Tesar lāua ʻo Kevin Allan i nā nūhou i nā nūpepa olakino e pili ana i ka haʻahaʻa haʻahaʻa o ka oxygen e hōʻino ai i ka lolo.
Ma kēia nīnauele, ua kūkākūkā ʻo Kauka Jiang Yigang i nā ACROBiosystems a me kāna mau hoʻoikaika ʻana i ka hakakā ʻana iā COVID-19 a me ka loaʻa ʻana o nā kano.
Ma kēia nīnauele, ua kūkākūkā ʻo News-Medical i ka hoʻomohala ʻana a me ke ʻano o nā antibodies monoclonal me David Apiyo, ka luna nui o nā noi ma Sartorius AG.
Hāʻawi ʻo News-Medical.Net i kēia lawelawe ʻike olakino e like me kēia mau ʻōlelo a me nā kūlana. E ʻoluʻolu e hoʻohana ʻia nā ʻike olakino i loaʻa ma kēia pūnaewele e kākoʻo a ʻaʻole e hoʻololi i ka pilina ma waena o nā maʻi a me nā kauka a me nā ʻōlelo aʻoaʻo a lākou e hāʻawi ai.
Hoʻohana mākou i nā kuki e hoʻonui i kou ʻike. Ma ka hoʻomau ʻana i ka nānā ʻana i kēia pūnaewele, ʻae ʻoe i kā mākou hoʻohana ʻana i nā kuki. ʻIke hou aku.