He lāʻau lapaʻau ʻo Cimetidine e ālai ana i ka hana ʻana o ka waika e nā sela hana waika i loko o ka ʻōpū a hiki ke hāʻawi waha ʻia, IM a i ʻole IV.

Hoʻohana ʻia ʻo Cimetidine e:

• hoʻomahaʻeha puʻuwaipili meʻaʻai ʻai ʻaia me ka ʻōpū ʻawaʻawa
• pale i ka ʻeha puʻuwai i lawe ʻia mai e ka ʻai ʻana a i ʻole ka inu ʻana i kekahi mau meaʻai amea inu

No ka papa olāʻau lapaʻaui kapa ʻia ʻo H2 (histamine-2) blockers e komo pū anaranitidine(Zantac),nizatidine(Axid), afamotidine(Pepcid). ʻO ka histamine kahi mea hana kūlohelohe e hoʻoulu ai i nā cell i loko o ka ʻōpū (parietal cell) e hana i ka waikawa. ʻO ka H2-blockers ke kāohi i ka hana o ka histamine ma nā pūnaewele, no laila e hōʻemi i ka hana ʻana o ka waikawa e ka ʻōpū.

No ka mea hiki ke hoʻopōʻino i ka ʻakika ʻōpū nuiesophagus, ka ʻōpū, a me ka duodenum e ka reflux a alakaʻi i ka ʻāʻī a me ka ʻulaʻula, e hōʻemi ana i ka ʻakika o ka ʻōpū e pale a ʻae i ka hoʻōla ʻana i ka maʻi a me nā maʻi ʻeha. Ua ʻae ʻia ʻo Cimetidine e ka FDA i ka makahiki 1977.