Tau ob xyoo lawm, albendazole tau pub dawb rau qhov kev pab cuam loj rau kev kho mob lymphatic filariasis. Kev tshuaj xyuas Cochrane tshiab tau tshuaj xyuas qhov ua tau zoo ntawm albendazole hauv lymphatic filariasis.
Lymphatic filariasis yog ib hom kab mob yoov tshaj cum uas muaj nyob hauv thaj chaw sov thiab subtropical uas tshwm sim los ntawm tus kab mob parasitic filariasis. Tom qab kis kab mob, cov larvae loj hlob mus rau cov neeg laus thiab cov phooj ywg tsim microfilariae (mf). MF ces yoov tshaj cum thaum noj cov ntshav, thiab kis tau mus rau lwm tus neeg.
Kev kis kab mob tuaj yeem kuaj tau los ntawm kev sim rau MF (microfilaraemia) lossis kab mob parasite antigens (antigenemia) lossis los ntawm kev kuaj pom cov neeg laus muaj sia nyob los ntawm ultrasound.
Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO) pom zoo kom muaj kev kho mob loj ntawm tag nrho cov pej xeem txhua xyoo rau tsawg kawg tsib xyoos. Lub hauv paus ntawm kev kho mob yog kev sib xyaw ntawm ob cov tshuaj: albendazole thiab microfilaricidal (antimalarial) tshuaj diethylcarbamazine (DEC) lossis ivermectin.
Albendazole ib nrab xyoo raug pom zoo nyob rau hauv cov cheeb tsam uas loiasis yog co-endemic, thiab DEC los yog ivermectin yuav tsum tsis txhob siv vim muaj kev pheej hmoo ntawm kev phiv loj.
Ob leeg ivermectin thiab DEK tshem tawm cov kab mob mf sai sai thiab tuaj yeem cuam tshuam lawv qhov rov tshwm sim dua. Txawm li cas los xij, mf ntau lawm yuav rov pib dua vim muaj kev txwv rau cov neeg laus. Albendazole tau raug txiav txim siab rau kev kho mob lymphatic filariasis vim tias txoj kev tshawb fawb tau tshaj tawm tias kev siv tshuaj ntau dhau ob peb lub lis piam ua rau muaj kev phiv loj heev uas qhia txog kev tuag ntawm cov neeg laus worms.
Ib tsab ntawv ceeb toom tsis raug ntawm WHO kev sab laj tom qab tau qhia tias albendazole muaj kev tua lossis fungicidal cuam tshuam rau cov neeg laus. Xyoo 2000, GSK tau pib pub dawb albendazole rau Lymphatic Filariasis Treatment Program.
Randomized soj ntsuam kev sim (RCTs) tau tshuaj xyuas qhov ua tau zoo thiab kev nyab xeeb ntawm albendazole ib leeg lossis ua ke nrog ivermectin lossis DEC. Qhov no tau ua raws los ntawm ntau qhov kev tshuaj xyuas ntawm RCTs thiab cov ntaub ntawv soj ntsuam, tab sis nws tsis paub meej tias albendazole puas muaj txiaj ntsig hauv lymphatic filariasis.
Raws li qhov no, kev tshuaj xyuas Cochrane luam tawm xyoo 2005 tau hloov kho los ntsuas qhov cuam tshuam ntawm albendazole rau cov pej xeem thiab cov zej zog uas muaj lymphatic filariasis.