Vitamin C, tseem hu ua ascorbic acid, yog ib qho tseem ceeb ntawm cov dej-soluble as-ham. Tib neeg thiab qee yam tsiaj txhu (xws li primates, npua) nyob ntawm cov vitamin C hauv cov khoom noj khoom haus ntawm cov txiv hmab txiv ntoo thiab zaub (liab kua txob, txiv kab ntxwv, strawberry, broccoli, txiv nkhaus taw, txiv qaub). Lub luag haujlwm tseem ceeb ntawm vitamin C hauv kev tiv thaiv thiab txhim kho kev kis kab mob tau raug lees paub hauv zej zog kho mob.
Ascorbic acid yog qhov tseem ceeb rau kev tiv thaiv kab mob. Nws muaj ib qho tseem ceeb tiv thaiv kab mob, immunomodulatory, antioxidant, anti-thrombosis thiab anti-viral zog.
Vitamin C zoo li muaj peev xwm tswj tau tus tswv tsev cov lus teb rau tus mob hnyav ua pa nyuaj rau tus mob coronavirus 2 (SARS-CoV-2). Coronavirus yog qhov ua rau muaj tus kabmob 2019 (COVID-19) kis thoob qhov txhia chaw, tshwj xeeb tshaj yog nyob rau lub sijhawm tseem ceeb. Hauv cov lus tsis ntev los no luam tawm hauv Preprints *, Patrick Holford li al. Kev daws lub luag haujlwm ntawm vitamin C ua ib qho kev pab kho mob rau cov kab mob ua pa, sepsis thiab COVID-19.
Kab lus no tham txog lub luag haujlwm tseem ceeb ntawm vitamin C hauv kev tiv thaiv theem tseem ceeb ntawm COVID-19, kab mob ua pa hnyav thiab lwm yam kab mob inflammatory. Vitamin C supplementation yuav tsum yog tus tiv thaiv lossis kho tus neeg sawv cev rau COVID-19- kho qhov tsis txaus los ntawm tus kab mob, txo cov kev ntxhov siab oxidative, txhim kho interferon ntau lawm thiab txhawb cov tshuaj tiv thaiv kab mob ntawm glucocorticoids.
Txhawm rau tswj hwm cov ntshav plasma ib txwm muaj rau cov neeg laus ntawm 50 µmol / l, vitamin C rau cov txiv neej yog 90 mg / d thiab rau cov poj niam 80 mg / d. Qhov no txaus los tiv thaiv scurvy (ib kab mob tshwm sim los ntawm qhov tsis muaj vitamin C). Txawm li cas los xij, qib no tsis txaus los tiv thaiv kev kis kab mob thiab kev ntxhov siab ntawm lub cev.
Yog li ntawd, Swiss Nutrition Society pom zoo kom ntxiv rau txhua tus neeg nrog 200 mg ntawm vitamin C-kom ua tiav cov khoom noj khoom haus ntawm cov pej xeem, tshwj xeeb tshaj yog cov neeg laus 65 xyoo thiab laus dua. Cov tshuaj no yog tsim los txhawb kev tiv thaiv kab mob. "
Nyob rau hauv physiological kev nyuaj siab, tib neeg cov ntshav vitamin C qib poob sai. Cov ntsiab lus ntawm cov vitamin C hauv cov neeg mob hauv tsev kho mob yog ≤11µmol/l, thiab lawv feem ntau raug kev txom nyem los ntawm kev mob ua pa nyuaj, sepsis lossis mob hnyav rau COVID-19.
Ntau cov ntaub ntawv tshawb fawb los ntawm thoob plaws ntiaj teb qhia tias qib vitamin C tsawg yog muaj nyob rau hauv cov neeg mob hnyav hauv tsev kho mob nrog mob ua pa, mob ntsws, mob sepsis thiab COVID-19-qhov kev piav qhia feem ntau yog kev noj zaub mov ntau ntxiv.
Qhov kev soj ntsuam meta tau hais txog cov kev soj ntsuam hauv qab no: 1) Vitamin C supplementation tuaj yeem txo qhov kev pheej hmoo ntawm mob ntsws, 2) Kev tshawb nrhiav tom qab tuag los ntawm COVID-19 pom tias mob ntsws thib ob, thiab 3) Vitamin C tsis txaus suav rau tag nrho cov pej xeem nrog. mob ntsws 62%.
Vitamin C muaj ib qho tseem ceeb homeostatic nyhuv raws li ib tug antioxidant. Nws paub tias muaj cov kab mob tua kab mob ncaj qha thiab tuaj yeem ua rau kev tsim cov tshuaj interferon. Nws muaj effector mechanisms nyob rau hauv ob qho tib si innate thiab adaptive tiv thaiv kab mob. Vitamin C txo cov pa oxygen reactive hom (ROS) thiab o los ntawm kev txo qhov ua kom NF-κB.
SARS-CoV-2 down-regulates the expression of type 1 interferon (tus tswv tsev lub ntsiab tiv thaiv kab mob), thaum ascorbic acid up-regulates cov tseem ceeb host defense proteins.
Lub sijhawm tseem ceeb ntawm COVID-19 (feem ntau yog lub sijhawm tuag) tshwm sim thaum lub sijhawm tsim tawm ntau dhau ntawm cov tshuaj tiv thaiv cytokines thiab chemokines. Qhov no ua rau kev txhim kho ntawm ntau lub cev tsis ua haujlwm. Nws muaj feem cuam tshuam rau kev tsiv teb tsaws thiab sib sau ntawm neutrophils hauv lub ntsws interstitium thiab bronchoalveolar kab noj hniav, qhov kawg yog qhov tseem ceeb ntawm ARDS (Acute Respiratory Distress Syndrome).
Qhov concentration ntawm ascorbic acid nyob rau hauv cov qog adrenal thiab pituitary caj pas yog peb mus rau kaum npaug ntau dua nyob rau hauv lwm yam kabmob. Raws li physiological kev nyuaj siab (ACTH stimulation) cov xwm txheej nrog rau kis kab mob, vitamin C raug tso tawm los ntawm adrenal cortex, ua rau cov ntshav plasma nce tsib npaug.
Vitamin C tuaj yeem txhim kho kev tsim cov cortisol, thiab txhim kho cov tshuaj tiv thaiv kab mob thiab endothelial cell tiv thaiv los ntawm glucocorticoids. Exogenous glucocorticoid steroids yog tib cov tshuaj uas tau raug pov thawj los kho COVID-19. Vitamin C yog ib qho tshuaj tiv thaiv kab mob ntau yam, uas ua lub luag haujlwm tseem ceeb hauv kev kho cov lus teb rau adrenal cortex (tshwj xeeb tshaj yog sepsis) thiab tiv thaiv endothelium los ntawm kev puas tsuaj oxidative.
Kev suav txog cov txiaj ntsig ntawm vitamin C rau kev mob khaub thuas-txo lub sijhawm, qhov hnyav thiab zaus ntawm tus mob khaub thuas noj vitamin C tuaj yeem txo qhov kev hloov pauv ntawm tus kab mob me me mus rau lub sijhawm tseem ceeb ntawm COVID-19.
Nws tau pom tias kev ntxiv cov vitamin C tuaj yeem txo qhov ntev ntawm kev nyob hauv ICU, txo lub sijhawm ua pa ntawm cov neeg mob hnyav nrog COVID-19, thiab txo qis kev tuag ntawm cov neeg mob sepsis uas xav tau kev kho mob vasopressors.
Nrog rau ntau yam kev mob raws plab, pob zeb hauv lub raum thiab lub raum tsis ua haujlwm thaum lub sijhawm siv tshuaj ntau, cov kws sau ntawv tau tham txog kev nyab xeeb ntawm kev noj qab haus huv ntawm qhov ncauj thiab cov hlab ntsha ntawm vitamin C. Kev nyab xeeb luv luv ntawm 2-8 g / hnub tuaj yeem pom zoo ( ua tib zoo tsis txhob noj tshuaj ntau rau cov neeg uas muaj keeb kwm ntawm lub raum pob zeb lossis kab mob raum). Vim tias nws yog dej-soluble, nws tuaj yeem tso tawm tsis pub dhau ob peb teev, yog li kev siv ntau zaus yog qhov tseem ceeb los tswj cov ntshav txaus thaum lub sijhawm muaj kab mob.
Raws li peb txhua tus paub, vitamin C tuaj yeem tiv thaiv kab mob thiab txhim kho kev tiv thaiv kab mob. Tshwj xeeb yog xa mus rau theem tseem ceeb ntawm COVID-19, vitamin C ua lub luag haujlwm tseem ceeb. Nws txo qis- tswj cov cua daj cua dub cytokine, tiv thaiv endothelium los ntawm kev puas tsuaj oxidative, ua lub luag haujlwm tseem ceeb hauv kev kho cov ntaub so ntswg, thiab txhim kho lub cev tiv thaiv kab mob.
Tus kws sau ntawv pom zoo tias cov tshuaj vitamin C yuav tsum tau ntxiv txhua hnub los txhawb cov pab pawg uas muaj kev pheej hmoo siab nrog kev tuag ntawm COVID-19 thiab vitamin C tsis txaus. Lawv yuav tsum nco ntsoov xyuas kom meej tias cov vitamin C txaus thiab nce koob tshuaj thaum tus kab mob kis tau, txog li 6-8 g / hnub. Ntau cov kev tshawb fawb ntawm cov vitamin C nyob ntawm qhov koob tshuaj tau txuas ntxiv mus thoob ntiaj teb kom paub meej tias nws lub luag haujlwm hauv kev tshem tawm COVID-19 thiab kom nkag siab zoo dua nws lub luag haujlwm raws li qhov muaj peev xwm kho tau.
Cov ntawv sau ua ntej yuav tshaj tawm cov ntaub ntawv tshawb fawb ua ntej uas tsis tau raug tshuaj xyuas, thiab yog li ntawd yuav tsum tsis txhob suav hais tias yog qhov tseeb, coj kev coj noj coj ua / kev coj noj coj ua ntsig txog kev noj qab haus huv lossis suav tias yog cov ntaub ntawv tseeb.
Tags: mob hlwb, mob ua pa nyuaj siab syndrome, anti-inflammatory, antioxidant, ascorbic acid, ntshav, broccoli, chemokine, mob hlwb, tus mob coronavirus, covid-19, corticosteroid, cortisol, cytokine, cytokine, raws plab, zaus, Glucocorticoids, cov tshuaj hormones, tiv thaiv kab mob kab mob, mob, interstitial, raum, mob raum, raum tsis ua haujlwm, Kev tuag, khoom noj khoom haus, oxidative stress, pandemic, pneumonia, respiratory, SARS-CoV-2, scurvy, Sepsis, mob hnyav ua pa kab mob, mob hnyav ua pa syndrome, strawberry, kev nyuaj siab, syndrome, zaub, kab mob, vitamin C
Ramya muaj PhD. Pune National Chemical Laboratory (CSIR-NCL) tau txais PhD hauv Biotechnology. Nws txoj haujlwm suav nrog kev ua haujlwm ntawm nanoparticles nrog cov molecules sib txawv ntawm kev txaus siab lom neeg, kawm cov tshuaj tiv thaiv kab mob thiab tsim cov ntawv thov siv tau.
Dwivedi, Ramya. (Lub Kaum Hli 23, 2020). Vitamin C thiab COVID-19: Kev tshuaj xyuas. Xov xwm kho mob. Tau txais los ntawm https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx nyob rau lub Kaum Ib Hlis 12, 2020.
Dwivedi, Ramya. "Vitamin C thiab COVID-19: Kev Ntsuam Xyuas." Xov xwm kho mob. Hnub tim 12 lub 11 hlis 2020..
Dwivedi, Ramya. "Vitamin C thiab COVID-19: Kev Ntsuam Xyuas." Xov xwm kho mob. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Tau txais lub Kaum Ib Hlis 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C thiab COVID-19: Kev Ntsuam Xyuas." Xov xwm-Kev kho mob, tshawb xyuas lub Kaum Ib Hlis 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Hauv kev xam phaj no, xibfwb Paul Tesar thiab Kevin Allan tau tshaj tawm xov xwm rau cov ntawv xov xwm kho mob txog tias cov pa oxygen ua rau lub hlwb qis npaum li cas.
Hauv kev xam phaj no, Dr. Jiang Yigang tau tham txog ACROBiosystems thiab nws cov kev siv zog hauv kev tawm tsam COVID-19 thiab nrhiav tshuaj tiv thaiv
Hauv kev xam phaj no, Xov Xwm-Kev Kho Mob tau tham txog kev txhim kho thiab kev ua tus cwj pwm ntawm cov tshuaj tiv thaiv kab mob monoclonal nrog David Apiyo, tus thawj coj loj ntawm cov ntawv thov ntawm Sartorius AG.
Xov Xwm-Medical.Net muab cov ntaub ntawv kho mob no ua raws li cov lus qhia thiab cov xwm txheej no. Thov nco ntsoov tias cov ntaub ntawv kho mob pom nyob rau hauv lub vev xaib no tsuas yog siv los txhawb thiab tsis hloov kev sib raug zoo ntawm cov neeg mob thiab kws kho mob thiab cov lus qhia kho mob uas lawv yuav muab tau.
Peb siv cov ncuav qab zib los txhim kho koj qhov kev paub. Los ntawm txuas ntxiv mus saib lub vev xaib no, koj pom zoo rau peb siv cov ncuav qab zib. Xav paub ntxiv.