High Quality Cefotaxime Sodium Cas# 64485-93-4

Specification

Product Name:	Cefotaxime Sodium
CAS No.:	64485-93-4
Molecular Formula:	C16H16N5NaO7S2
Molecular Weight:	477.44g/mol
Appearance:	White crystalline powder
Assay:	99%min

 

Product name	Cefotaxime Sodium
CAS:	64485-93-4
MF:	C16H16N5NaO7S2
MW:	477.45
EINECS:	264-915-9
Cefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant. The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor. Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.

What is Cefotaxime Sodium ?

Cefotaxime Sodium as a semi-synthetic third-generation cephalosporins, for most Gram-positive bacteria and-negative bacteria have strong antibacterial activity, antibacterial spectrum, including Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, bacterial intestinal gas production , Proteus, and Staphylococcus aureus meningitis is so on.

Application of Cefotaxime Sodium

Treatment of infections of lower respiratory tract including pneumonia, urinary tract, skin and skin structures, bone and joints; treatment of bacteremia/septicemia, CNS infections, intra-abdominal infections including peritonitis, gynecological infections including pelvic inflammatory disease, endometritis and pelvic cellulitis caused by susceptible strains of specific microorganisms; perioperative prophylaxis.

 Function of Cefotaxime Sodium

The main clinical infection for susceptible strains of meningitis, pneumonia, skin and soft tissue infections, peritonitis, urinary tract infections, gonorrhea, liver and gallbladder infection, surgical trauma, sepsis, and genital infections. As a treatment for gonorrhea has been first-line drugs