Rabbit coccidiosis bụ ọrịa na-efe efe nke otu ma ọ bụ karịa n'ime ụdị 16 nke ụdị apicomplexan kpatara.Eimeria stiedae.^1-4A na-eji mgbaàmà izugbe na-agwọ ọrịa ahụ site n'ịkụ azụ, mbelata oriri nri, afọ ọsịsa ma ọ bụ afọ ntachi, mmụba imeju, ascites, icterus, mgbakasị afọ, na ọnwụ.³Enwere ike igbochi coccidiosis na oke bekee ma jiri ọgwụ mee ihe.^1,3,5,6Toltrazuril (Tol), 1-[3-methyl-4- (4-trifluoromethylsulfanyl-phenoxy) -phenyl] -3-methyl-1,3,5-triazin-2,4,6-trioneOnyonyo 1), bụ ngwakọta triazinetrione symmetrical nke a na-ejikarị egbochi na ịlụso coccidiosis ọgụ.^7-10Otú ọ dị, n'ihi na-adịghị mma aqueous solubility, Tol siri ike na-etinye obi gị dum site eriri afọ tract (GI). Ebelatala mmetụta ụlọ ọgwụ nke Tol n'ihi ike ya na traktị GI.

Ọgụgụ 1 Ọdịdị kemịkalụ nke toltrazuril.

Usoro ụfọdụ emeriela ụkọ mmiri na-adịghị mma nke Tol, dị ka mgbasa siri ike, ike ultrafine, na nanoemulsion.^11-13Dị ka ugbu a kasị dị irè usoro maka ịba ụba solubility, Tol siri ike dispersion naanị mụbara solubility nke Tol ka 2,000 ugboro,¹¹nke na-egosi na solubility ya ka kwesịrị ịkwalite nke ọma site na usoro ndị ọzọ. Na mgbakwunye, mgbasa siri ike na nanoemulsion adịghị eguzosi ike na adịghị mma ịchekwa, ebe ike ultrafine chọrọ akụrụngwa ọkaibe iji mepụta.

A na-eji β-cyclodextrin (β-CD) n'ọtụtụ ebe n'ihi nha oghere ya pụrụ iche, arụmọrụ nke mgbagwoju ọgwụ, yana nkwalite nke nkwụsi ike ọgwụ, solubility, na bioavailability.^14,15Maka ọkwa nhazi ya, β-CD ka edepụtara n'ọtụtụ ebe ọgwụ pharmacopoeia, gụnyere US Pharmacopoeia/National Formulary, European Pharmacopoeia, na Japanese Pharmaceutical Codex.^16,17Hydroxypropyl-β-CD (HP-β-CD) bụ ihe nrụpụta hydroxyalkyl β-CD nke a na-amụ nke ọma na mgbagwoju nsonye ọgwụ n'ihi ike ntinye ya na oke mmiri solubility.^18-21Nnyocha ọmụmụ toxicologic akọwo maka nchekwa nke HP-β-CD na nchịkwa intravenous na nke ọnụ na ahụ mmadụ,²²na HP-β-CD ejirila na usoro ụlọ ọgwụ iji merie nsogbu solubility na-adịghị mma ma kwalite bioavailability.²³

Ọ bụghị ọgwụ niile nwere akụrụngwa a ga-eji HP-β-CD mee mgbagwoju anya. Achọpụtara Tol nwere ihe ndị a dabere na ọnụ ọgụgụ dị ukwuu nke ọrụ nyocha nyocha. Iji bulie solubility na bioavailability nke Tol site na ntinye mgbagwoju anya na HP-β-CD, toltrazuril-hydroxypropyl-β-cyclodextrin inclusion complex (Tol-HP-β-CD) kwadebere site na usoro mkpali na-akpali akpali na ọmụmụ a, na mkpa dị mkpa. -Layer chromatography (TLC), Fourier transform infrared (FTIR) spectroscopy, na nuclear magnetik resonance (NMR) spectroscopy bụ. arụ ọrụ iji kọwaa Tol-HP-β-CD nwetara. Profaịlụ pharmacokinetic nke Tol na Tol-HP-β-CD na oke bekee mgbe nchịkwa ọnụ gasịrị ka agbakwunyere na vivo.