Vitamin C, nke a makwaara dị ka ascorbic acid, bụ ihe dị mkpa na-edozi mmiri na-agbaze. Ụmụ mmadụ na ụfọdụ anụmanụ ndị ọzọ (dị ka primates, pigs) na-adabere na vitamin C na nri nri nke mkpụrụ osisi na akwụkwọ nri ( ose uhie, oroma, strawberry, broccoli, mango, lemon). Achọpụtala ọrụ vitamin C nwere n'igbochi na imeziwanye ọrịa na mpaghara ahụike.
Ascorbic acid dị mkpa maka mmeghachi omume mgbochi. Ọ nwere mkpa mgbochi mkpali, immunomodulatory, antioxidant, mgbochi thrombosis na mgbochi nje Njirimara.
Vitamin C dị ka ọ nwere ike ịhazi nzaghachi onye ọbịa na nnukwu ọrịa iku ume coronavirus 2 (SARS-CoV-2). Coronavirus bụ ihe na-akpata ọrịa ọrịa coronavirus nke afọ 2019 (COVID-19), ọkachasị Ọ bụ n'oge dị oke egwu. N’okwu na-adịbeghị anya e bipụtara na Preprints *, Patrick Holford et al. Doziri ọrụ vitamin C dị ka ọgwụgwọ inyeaka maka ọrịa iku ume, sepsis na COVID-19.
Edemede a na-atụle ọrụ vitamin C nwere ike na igbochi ọnọdụ dị oke egwu nke COVID-19, nnukwu ọrịa iku ume na ọrịa ndị ọzọ na-akpasu iwe. A na-atụ anya mgbakwunye vitamin C ka ọ bụrụ ihe mgbochi ma ọ bụ ọgwụgwọ maka COVID-19 na-edozi adịghị ike nke ọrịa ahụ kpatara, na-ebelata nrụgide oxidative, na-eme ka mmepụta interferon dịkwuo elu na ịkwado mmetụta mgbochi mkpali nke glucocorticoids.
Iji nọgide na-enwe ọkwa plasma nkịtị na ndị okenye na 50 μmol / l, usoro vitamin C maka ụmụ nwoke bụ 90 mg / d na ụmụ nwanyị 80 mg / d. Nke a zuru ezu iji gbochie scurvy (ọrịa nke enweghị vitamin C kpatara). Otú ọ dị, ọkwa a ezughị ezu iji gbochie ikpughe nje na nrụgide physiological.
Ya mere, Switzerland Nutrition Society na-atụ aro ka onye ọ bụla tinye 200 mg nke vitamin C-iji mejupụta oghere nri nke ọha mmadụ, karịsịa ndị okenye 65 afọ na karịa. Emebere mgbakwunye a iji mee ka usoro ahụ ji alụso ọrịa ọgụ sie ike. "
N'okpuru ọnọdụ nrụgide physiological, ọkwa vitamin C nke mmadụ na-agbada ngwa ngwa. Ọdịnaya vitamin C nke ndị ọrịa nọ n'ụlọ ọgwụ bụ ≤11µmol/l, na ọtụtụ n'ime ha na-arịa nnukwu ọrịa iku ume, sepsis ma ọ bụ COVID-19 siri ike.
Nnyocha dị iche iche sitere na gburugburu ụwa na-egosi na ọkwa vitamin C dị ala na-adịkarị na ndị ọrịa nọ n'ụlọ ọgwụ na-arịa ọrịa iku ume, oyi baa, sepsis na COVID-19-nkọwa nwere ike ịbụ ụbara oriri metabolic.
Meta-analysis mere ka nlebanya ndị a pụta ìhè: 1) Ntinye vitamin C nwere ike ibelata ihe ize ndụ nke oyi baa, 2) Nnyocha ndị nwụrụ anwụ mgbe COVID-19 nwụsịrị gosiri na oyi baa nke abụọ, na 3) ụkọ vitamin C ruru ngụkọta ọnụ ọgụgụ ndị mmadụ. oyi baa 62%.
Vitamin C nwere mmetụta homeostatic dị mkpa dị ka antioxidant. A maara na ọ na-arụ ọrụ igbu nje virus kpọmkwem ma nwee ike ịbawanye mmepụta nke interferon. Ọ nwere mmetụta mmetụta na ma ebumpụta ụwa na ime usoro dịghịzi. Vitamin C na-ebelata ụdị oxygen na-emeghachi omume (ROS) na mbufụt site na ibelata ọrụ NF-κB.
SARS-CoV-2 na-achịkwa ngosipụta nke ụdị 1 interferon (usoro nchebe mgbochi nke onye ọbịa), ebe ascorbic acid na-achịkwa protein ndị isi ndị ọbịa.
Oge dị oke egwu nke COVID-19 (nke na-abụkarị akụkụ na-egbu egbu) na-eme n'oge mmepụta nke cytokines na chemokines na-akpasu iwe dị irè. Nke a butere mmepe nke otutu akụkụ ahụ. Ọ metụtara mbugharị na nchịkọta neutrophils na interstitium ngụgụ na oghere bronchoalveolar, nke ikpeazụ bụ isi ihe na-achọpụta ARDS (Acute Respiratory Distress Syndrome).
Ịta nke ascorbic acid na adrenal glands na pituitary gland bụ ugboro atọ ma ọ bụ iri karịa akụkụ ọ bụla ọzọ. N'okpuru nrụgide anụ ahụ (ACTH mkpali) gụnyere ikpughe nje, a na-ahapụ vitamin C na cortex adrenal, na-eme ka ọkwa plasma mụbaa okpukpu ise.
Vitamin C nwere ike ịkwalite mmepụta nke cortisol, ma kwalite mgbochi mkpali na endothelial cell mmetụta nke glucocorticoids. Glucocorticoid steroid nke na-apụ apụ bụ naanị ọgwụ egosipụtara na ọ na-agwọ COVID-19. Vitamin C bụ homonụ na-akpali akpali nke nwere mmetụta dị iche iche, nke na-arụ ọrụ dị mkpa n'ịgbazigharị nzaghachi nrụgide cortex adrenal (karịsịa sepsis) na ichebe endothelium site na mmebi oxidative.
N'iburu n'uche mmetụta vitamin C nwere na oyi-ibelata ogologo oge, ogo na ugboro ole oyi na-ewere vitamin C nwere ike ibelata mgbanwe site na ọrịa dị nro gaa n'oge dị oke egwu nke COVID-19.
Achọpụtala na mgbakwunye vitamin C nwere ike belata ogologo oge ịnọ na ICU, belata oge ikuku nke ndị ọrịa nwere COVID-19, ma belata ọnụọgụ ọnwụ nke ndị ọrịa sepsis chọrọ ọgwụgwọ na vasopressors.
N'iburu n'uche ọnọdụ dị iche iche nke afọ ọsịsa, akụrụ akụrụ na ọdịda akụrụ n'oge oke doses, ndị na-ede akwụkwọ kwurịtara nchekwa nke ọnụ na nchịkwa intravenous nke vitamin C. Enwere ike ịkwado nnukwu dose nke 2-8 g / ụbọchị dị mma. jiri nlezianya zere nnukwu doses maka ndị nwere akụkọ ihe mere eme nke akụrụ ma ọ bụ ọrịa akụrụ). N'ihi na ọ na-agbaze mmiri, enwere ike ịpụ ya n'ime awa ole na ole, ya mere ugboro ugboro usoro ọgwụgwọ dị mkpa iji nọgide na-enwe ọkwa ọbara zuru oke n'oge ọrịa na-arụ ọrụ.
Dị ka anyị niile maara, vitamin C nwere ike igbochi ọrịa ma melite nzaghachi mgbochi. Karịsịa na-ezo aka na ọkwa dị oke egwu nke COVID-19, vitamin C na-arụ ọrụ dị mkpa. Ọ na-achịkwa oké ifufe cytokine, na-echebe endothelium site na mmebi oxidative, na-arụ ọrụ dị mkpa na nrụzi anụ ahụ, ma na-eme ka mmeghachi omume na-adịghị ala ala maka ọrịa.
Onye ode akwụkwọ na-atụ aro na ekwesịrị ịgbakwunye mgbakwunye vitamin C kwa ụbọchị iji gbaa ndị otu nwere ihe egwu dị elu nwere oke ọnwụ COVID-19 yana ụkọ vitamin C. Ha kwesịrị ijide n'aka na vitamin C zuru oke ma na-abawanye dose mgbe nje ahụ butere, ruo 6-8 g / ụbọchị. Ọtụtụ ọmụmụ ndị otu vitamin C dabere na dose na-aga n'ihu n'ụwa niile iji kwado ọrụ ya na ibelata COVID-19 yana ịghọta ọrụ ya nke ọma dị ka ike ọgwụgwọ.
Mbipụta ga-ebipụta akụkọ izizi nke sayensị na-enyochabeghị nke ndị ọgbọ, yabụ na ekwesighi ka ewere ya dị ka mmechi, na-eduzi omume ụlọ ọgwụ / omume metụtara ahụike ma ọ bụ were ozi zuru oke.
Tags: nnukwu nsogbu iku ume, mgbochi mkpali, antioxidant, ascorbic acid, ọbara, broccoli, chemokine, coronavirus, coronavirus ọrịa COVID-19, corticosteroid, cortisol, cytokine, cytokine, afọ ọsịsa, ugboro, Glucocorticoids, homonụ, dịghịzi nzaghachi, dịghịzi usoro, mbufụt, interstitial, akụrụ, akụrụ ọrịa, akụrụ ọdịda, ọnwụ, nri, oxidative nchegbu, ọrịa na-efe efe, oyi baa, akụkụ okuku ume na SARS-CoV-2, scurvy, Sepsis, nnukwu akụkụ okuku ume na ọrịa, oké nnukwu akụkụ okuku ume ọrịa, strawberry, nchekasị, ọrịa, akwụkwọ nri, nje, vitamin C.
Ramya nwere PhD. Pune National Chemical Laboratory (CSIR-NCL) nwetara PhD na Biotechnology. Ọrụ ya gụnyere ịrụ ọrụ nanoparticles nwere mkpụrụ ndụ dị iche iche nke mmasị ndu, na-amụ usoro mmeghachi omume na iwulite ngwa bara uru.
Dwivedi, Ramya. (2020, Ọktoba 23). Vitamin C na COVID-19: nyocha. Akụkọ ahụike. Ewepụtara na https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx na Nọvemba 12, 2020.
Dwivedi, Ramya. "Vitamin C na COVID-19: Nyocha." Akụkọ ahụike. Nọvemba 12, 2020. .
Dwivedi, Ramya. "Vitamin C na COVID-19: Nyocha." Akụkọ ahụike. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Nweta na Nọvemba 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C na COVID-19: Nyocha." News-Medical, chọgharịrị na Nọvemba 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
N'ajụjụ ọnụ a, Prọfesọ Paul Tesar na Kevin Allan bipụtara akụkọ n'akwụkwọ akụkọ ahụike gbasara etu ikuku oxygen si emebi ụbụrụ.
N'ajụjụ ọnụ a, Dr. Jiang Yigang tụlere ACROBiosystems na mbọ ya na-alụ ọgụ COVID-19 na ịchọta ọgwụ mgbochi ọrịa.
N'ajụjụ ọnụ a, News-Medical tụlere mmepe na njirimara nke ọgwụ mgbochi monoclonal na David Apiyo, onye isi njikwa ngwa na Sartorius AG.
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