Kafukufuku waku Danish adawonetsa kuti kwa odwala omwe akuchulukirachulukira matenda osachiritsika am'mapapo (COPD), amoxicillin yekha amakhala ndi zotsatira zabwino kuposa amoxicillin wophatikizidwa ndi mankhwala ena ophatikizika, clavulanic acid.
Kafukufukuyu wotchedwa "Antibiotic Therapy in Acute Exacerbations of COPD: Patient Outcomes of Amoxicillin ndi Amoxicillin/Clavulanic Acid-Data from 43,636 Outpatients" idasindikizidwa mu Journal of Respiratory Research.
Kuwonjezeka kwakukulu kwa COPD ndizochitika zomwe zizindikiro za wodwalayo zimakula mwadzidzidzi. Popeza kuwonjezereka kumeneku nthawi zambiri kumakhala kokhudzana ndi matenda a bakiteriya, chithandizo ndi maantibayotiki (mankhwala omwe amapha mabakiteriya) ndi gawo la chisamaliro.
Ku Denmark, pali mitundu iwiri ya maantibayotiki yomwe ingagwiritsidwe ntchito pochiza kuwonjezereka kotereku. Mmodzi ndi 750 mg amoxicillin katatu patsiku, ndipo winayo ndi 500 mg amoxicillin kuphatikiza 125 mg clavulanic acid, komanso katatu patsiku.
Amoxicillin ndi clavulanic acid onse ndi beta-lactam, omwe ndi maantibayotiki omwe amagwira ntchito posokoneza kupanga makoma a ma cell a bakiteriya, motero amapha mabakiteriya.
Mfundo yayikulu yophatikizira maantibayotiki awiriwa ndikuti clavulanic acid ndiyothandiza polimbana ndi mabakiteriya osiyanasiyana. Komabe, chithandizo cha amoxicillin chokha chimatanthawuza kuti mankhwala amodzi amatha kuperekedwa pamlingo wokulirapo, womwe pamapeto pake ukhoza kupha mabakiteriya bwino.
Tsopano, gulu la ofufuza Danish mwachindunji anayerekezera zotsatira za regimens awiriwa zochizira exacerbations pachimake COPD.
Ofufuzawa adagwiritsa ntchito deta yochokera ku Denmark COPD registry, kuphatikizapo deta yochokera m'mabuku ena a dziko, kuti azindikire odwala 43,639 omwe ali ndi vuto lalikulu lomwe adalandira chimodzi mwa njira ziwiri zomwe zafufuzidwa. Mwachindunji, anthu 12,915 adamwa amoxicillin yekha ndipo anthu 30,721 adamwa mankhwala osakanikirana. Ndikoyenera kudziwa kuti palibe odwala omwe adafufuzidwa adagonekedwa m'chipatala chifukwa chakuchulukira kwa COPD, zomwe zikuwonetsa kuti kuukirako sikunali koopsa.
Poyerekeza ndi kuphatikiza kwa amoxicillin ndi clavulanic acid, chithandizo cha amoxicillin chokha chingachepetse chiopsezo chogonekedwa m'chipatala chifukwa cha chibayo kapena kufa ndi 40% pakadutsa masiku 30. Amoxicillin yekha amalumikizidwanso ndi kutsika kwa 10% kwa chiwopsezo chogonekedwa m'chipatala chosakhala chibayo kapena kufa komanso kutsika kwa 20% pachiwopsezo chogonekedwa m'chipatala kapena imfa.
Pamiyeso yonseyi, kusiyana pakati pa mankhwala awiriwa ndikofunika kwambiri. Kusanthula kowonjezera kowerengera nthawi zambiri kudzapeza zotsatira zofananira.
Ofufuzawo analemba kuti: "Tinapeza kuti poyerekeza ndi AMC [amoxicillin kuphatikiza clavulanic acid], AECOPD [COPD exacerbation] odwala omwe amathandizidwa ndi AMX [amoxicillin yekha] ali pachiwopsezo chogonekedwa m'chipatala kapena kufa ndi chibayo mkati mwa masiku 30 Ochepa kwambiri."
Gululo likuganiza kuti chifukwa chimodzi chomwe chingapangire zotsatirazi ndi kusiyana kwa mlingo pakati pa ma antibiotic regimens awiri.
"Akamwedwa pamlingo womwewo, AMC [kuphatikiza] sikungakhale kotsika kuposa AMX [amoxicillin yekha]," adalemba.
Ponseponse, kusanthulako "kumathandizira kugwiritsa ntchito AMX ngati mankhwala omwe amawakonda odwala omwe ali ndi AECOPD," ofufuzawo adamaliza chifukwa "kuwonjezera kwa clavulanic acid ku amoxicillin sikukhudzana ndi zotsatira zabwino."
Malingana ndi ochita kafukufuku, kuchepetsa kwakukulu kwa phunziroli ndi chiopsezo cha chisokonezo chifukwa cha zizindikiro-mwa kuyankhula kwina, anthu omwe ali ndi vuto losauka akhoza kulandira chithandizo chophatikizana. Ngakhale kuti kusanthula kwa chiwerengero cha ochita kafukufuku kumayesa kufotokoza izi, n'zothekabe kuti kusiyana koyambirira kwa mankhwala kunafotokozera zotsatira zina.
Tsambali ndi tsamba lazambiri komanso zambiri za matendawa. Sichipereka malangizo achipatala, matenda kapena chithandizo. Izi sizikulowa m'malo mwa upangiri wachipatala, matenda kapena chithandizo. Ngati muli ndi mafunso okhudza matenda, nthawi zonse funsani malangizo kwa dokotala wanu kapena wothandizira zaumoyo woyenerera. Musanyalanyaze malangizo achipatala kapena kuchedwetsa kupita kuchipatala chifukwa cha zomwe mwawerenga pa webusaitiyi.