Kwa zaka makumi awiri, albendazole yaperekedwa ku pulogalamu yayikulu yochizira matenda a lymphatic filariasis. Ndemanga yosinthidwa ya Cochrane idawunika mphamvu ya albendazole mu lymphatic filariasis.
Lymphatic filariasis ndi matenda ofalitsidwa ndi udzudzu omwe amapezeka m'madera otentha komanso otentha chifukwa cha matenda a parasitic filariasis. Pambuyo pa matenda, mphutsi zimakula kukhala zazikulu ndi kukwatirana kupanga microfilariae (mf). MF imatengedwa ndi udzudzu pamene ikudya magazi, ndipo matendawa amatha kufalikira kwa munthu wina.
Matendawa amatha kuzindikiridwa ndi kuyezetsa kwa MF (microfilaraemia) kapena tizilombo toyambitsa matenda (antigenemia) kapena pozindikira mphutsi zazikulu zamoyo ndi ultrasound.
Bungwe la World Health Organization (WHO) limalimbikitsa kuti anthu ambiri azilandira chithandizo chamankhwala chaka chilichonse kwa zaka zosachepera zisanu. Maziko a chithandizo ndi kuphatikiza kwa mankhwala awiri: albendazole ndi microfilaricidal (antimalarial) mankhwala diethylcarbamazine (DEC) kapena ivermectin.
Albendazole semiannually tikulimbikitsidwa kumadera kumene loiasis ndi co-endemic, ndi DEC kapena ivermectin sayenera kugwiritsidwa ntchito chifukwa chiopsezo mavuto aakulu.
Onse ivermectin ndi DEK amachotsa matenda a mf mwachangu ndipo amatha kulepheretsa kuyambiranso. Komabe, kupanga kwa mf kudzayambiranso chifukwa cha kuchepa kochepa kwa akuluakulu. Albendazole ankaganiziridwa kuti azichiza lymphatic filariasis chifukwa kafukufuku wasonyeza kuti mlingo waukulu woperekedwa kwa milungu ingapo unabweretsa zotsatira zoopsa zomwe zimasonyeza imfa ya mphutsi zazikulu.
Lipoti losakhazikika la zokambirana za WHO linanena kuti albendazole ili ndi kupha kapena fungicidal zotsatira kwa akuluakulu. Mu 2000, GSK inayamba kupereka albendazole ku Lymphatic Filariasis Treatment Programme.
Mayesero achipatala osasinthika (RCTs) apenda mphamvu ndi chitetezo cha albendazole yekha kapena kuphatikiza ndi ivermectin kapena DEC. Izi zatsatiridwa ndi ndemanga zingapo mwadongosolo za RCTs ndi deta yowonetsetsa, koma sizikudziwika ngati albendazole ili ndi phindu lililonse mu filariasis ya lymphatic.
Poganizira izi, ndemanga ya Cochrane yofalitsidwa mu 2005 yasinthidwa kuti awone momwe albendazole imakhudzira anthu ndi madera omwe ali ndi lymphatic filariasis.