Vitamini C, yomwe imadziwikanso kuti ascorbic acid, ndiyofunikira pakusungunuka m'madzi. Anthu ndi nyama zina (monga anyani, nkhumba) amadalira vitamini C mu zakudya za zipatso ndi ndiwo zamasamba (tsabola wofiira, lalanje, sitiroberi, broccoli, mango, ndimu). Udindo womwe ungakhalepo wa vitamini C popewa komanso kuwongolera matenda wadziwika m'magulu azachipatala.
Ascorbic acid ndiyofunikira pakuyankha kwa chitetezo chamthupi. Ili ndi anti-yotupa, immunomodulatory, antioxidant, anti-thrombosis ndi anti-viral properties.
Vitamini C akuwoneka kuti amatha kuwongolera momwe wolandirayo akuyankhira ku matenda oopsa kwambiri a kupuma kwa coronavirus 2 (SARS-CoV-2). Coronavirus ndiyemwe wayambitsa mliri wa 2019 coronavirus (COVID-19), makamaka Ili munthawi yovuta. M'mawu aposachedwa omwe adasindikizidwa mu Preprints *, Patrick Holford et al. Anathetsa ntchito ya vitamini C ngati chithandizo chothandizira matenda opuma, sepsis ndi COVID-19.
Nkhaniyi ikufotokoza za ntchito yomwe vitamini C ingagwire popewa gawo lofunikira la COVID-19, matenda opumira pachimake ndi matenda ena otupa. Vitamini C supplementation ikuyembekezeka kukhala njira yodzitetezera kapena yochizira zofooka za COVID-19 zomwe zimayambitsidwa ndi matendawa, kuchepetsa kupsinjika kwa okosijeni, kupititsa patsogolo kupanga kwa interferon ndikuthandizira zotsutsana ndi zotupa za glucocorticoids.
Pofuna kusunga mlingo wa plasma wabwinobwino mwa akulu pa 50 µmol/l, mlingo wa vitamini C kwa amuna ndi 90 mg/d ndipo kwa akazi 80 mg/d. Izi ndizokwanira kupewa scurvy (matenda omwe amayamba chifukwa cha kusowa kwa vitamini C). Komabe, mulingo uwu siwokwanira kupewa kukhudzana ndi ma virus komanso kupsinjika kwa thupi.
Choncho, Swiss Nutrition Society imalimbikitsa kuwonjezera munthu aliyense ndi 200 mg wa vitamini C-kuti athetse kusiyana kwa zakudya za anthu ambiri, makamaka akuluakulu a zaka 65 ndi kuposerapo. Chowonjezera ichi chapangidwa kuti chilimbikitse chitetezo cha mthupi. "
Pansi pa zovuta zakuthupi, kuchuluka kwa vitamini C mu seramu yamunthu kumatsika mwachangu. Seramu ya vitamini C ya odwala omwe ali m'chipatala ndi ≤11µmol/l, ndipo ambiri a iwo amadwala matenda opumira, sepsis kapena COVID-19.
Kafukufuku wosiyanasiyana padziko lonse lapansi akuwonetsa kuti kuchepa kwa vitamini C kumakhala kofala mwa odwala omwe ali m'chipatala omwe akudwala kwambiri omwe ali ndi matenda opumira, chibayo, sepsis ndi COVID-19-mafotokozedwe omwe angachitike ndikuwonjezeka kwa metabolic.
Kuwunika kwa meta kunawonetsa izi: 1) Kuphatikizika kwa Vitamini C kumatha kuchepetsa kwambiri chiwopsezo cha chibayo, 2) Kufufuza pambuyo pakufa kwa COVID-19 kunawonetsa chibayo chachiwiri, ndipo 3) Kuperewera kwa Vitamini C kudawerengera anthu onse omwe ali ndi vuto la chibayo. chibayo 62%.
Vitamini C imakhala ndi homeostatic effect yofunika kwambiri ngati antioxidant. Amadziwika kuti ali ndi ntchito yopha ma virus mwachindunji ndipo amatha kuwonjezera kupanga kwa interferon. Ili ndi njira zogwirira ntchito m'makina obadwa nawo komanso osinthika. Vitamini C imachepetsa mitundu ya okosijeni yokhazikika (ROS) ndi kutupa mwa kuchepetsa kuyambitsa kwa NF-κB.
SARS-CoV-2 pansi-imayang'anira kufotokozera kwa mtundu woyamba wa interferon (njira yayikulu yodzitchinjiriza ya wolandirayo), pomwe ascorbic acid imayang'anira mapuloteni oteteza omwe ali nawo.
Gawo lovuta kwambiri la COVID-19 (nthawi zambiri gawo lakupha) limachitika pakuchulukirachulukira kwa ma cytokines ndi ma chemokines ogwira ntchito yotupa. Izi zinapangitsa kuti ziwalo zambiri ziwonongeke. Zimakhudzana ndi kusamuka ndi kudzikundikira kwa neutrophils mu lung interstitium ndi bronchoalveolar cavity, chotsatiracho kukhala chodziwika bwino cha ARDS (Acute Respiratory Distress Syndrome).
Kuchuluka kwa ascorbic acid mu adrenal glands ndi pituitary gland ndipamwamba katatu mpaka khumi kuposa chiwalo china chilichonse. Pansi pa physiological stress (ACTH stimulation) mikhalidwe kuphatikizapo kuwonetseredwa kwa mavairasi, vitamini C amatulutsidwa kuchokera ku adrenal cortex, zomwe zimapangitsa kuti madzi a m'magazi achuluke kasanu.
Vitamini C imatha kupititsa patsogolo kupanga cortisol, ndikuwonjezera anti-inflammatory and endothelial cell protective effect of glucocorticoids. Exogenous glucocorticoid steroids ndi mankhwala okhawo omwe atsimikiziridwa kuti amachiza COVID-19. Vitamini C ndi timadzi tambiri timene timatulutsa timadzi tambiri, timene timathandiza kwambiri pakuyanjanitsa kupsinjika kwa adrenal cortex (makamaka sepsis) ndikuteteza endothelium ku kuwonongeka kwa okosijeni.
Poganizira momwe vitamini C imakhudzira chimfine-kuchepetsa nthawi, kuuma komanso kuchuluka kwa chimfine-kutenga vitamini C kumatha kuchepetsa kusintha kuchokera ku matenda ocheperako kupita ku nthawi yovuta ya COVID-19.
Zawoneka kuti vitamini C yowonjezera imatha kufupikitsa nthawi yokhala ku ICU, kufupikitsa nthawi yopumira ya odwala omwe akudwala kwambiri omwe ali ndi COVID-19, ndikuchepetsa kufa kwa odwala sepsis omwe amafunikira chithandizo ndi vasopressors.
Poganizira zochitika zosiyanasiyana za kutsekula m'mimba, miyala ya impso ndi kulephera kwaimpso panthawi ya mlingo waukulu, olembawo adakambirana za chitetezo cha m'kamwa ndi mtsempha wa vitamini C. Mlingo wotetezeka wanthawi yochepa wa 2-8 g / tsiku ukhoza kulangizidwa. mosamala pewani mlingo waukulu kwa anthu omwe ali ndi mbiri ya miyala ya impso kapena matenda a impso). Chifukwa ndi sungunuka m'madzi, imatha kutulutsidwa mkati mwa maola ochepa, choncho pafupipafupi mlingo ndi wofunikira kuti mukhale ndi magazi okwanira pa nthawi ya matenda opatsirana.
Monga tonse tikudziwira, vitamini C imatha kuteteza matenda ndikuwonjezera chitetezo cha mthupi. Makamaka ponena za gawo lovuta la COVID-19, vitamini C amatenga gawo lalikulu. Imawongolera mkuntho wa cytokine, imateteza endothelium ku kuwonongeka kwa okosijeni, imagwira ntchito yofunika kwambiri pakukonzanso minofu, ndikuwongolera chitetezo chamthupi ku matenda.
Wolembayo amalimbikitsa kuti zowonjezera za vitamini C ziyenera kuwonjezeredwa tsiku lililonse kulimbikitsa magulu omwe ali pachiwopsezo chachikulu omwe ali ndi kufa kwa COVID-19 komanso kuchepa kwa vitamini C. Ayenera kuwonetsetsa kuti vitamini C ndi wokwanira ndikuwonjezera mlingo pamene kachilomboka katenga kachilomboka, mpaka 6-8 g / tsiku. Maphunziro angapo a gulu la vitamini C omwe amadalira mlingo akupitilira padziko lonse lapansi kuti atsimikizire ntchito yake pochotsa COVID-19 komanso kumvetsetsa bwino ntchito yake ngati chithandizo chamankhwala.
Preprints adzasindikiza malipoti oyambirira a sayansi omwe sanawunikidwe ndi anzawo, choncho sayenera kuganiziridwa kuti ndi omaliza, kutsogolera machitidwe azachipatala / machitidwe okhudzana ndi thanzi kapena kuganiziridwa kuti ndi chidziwitso chotsimikizika.
Tags: pachimake kupuma nkhawa syndrome, anti-yotupa, antioxidant, ascorbic acid, magazi, broccoli, chemokine, coronavirus, coronavirus matenda COVID-19, corticosteroid, cortisol, cytokine, cytokine, kutsegula m'mimba, pafupipafupi, Glucocorticoids, mahomoni, chitetezo cha mthupi, chitetezo cha mthupi dongosolo, kutupa, interstitial, impso, matenda a impso, impso kulephera, kufa, zakudya, oxidative nkhawa, mliri, chibayo, kupuma, SARS-CoV-2, scurvy, Sepsis, kwambiri pachimake kupuma matenda, kwambiri pachimake kupuma syndrome, sitiroberi, nkhawa, syndrome, masamba, kachilombo, vitamini C.
Ramya ali ndi PhD. Pune National Chemical Laboratory (CSIR-NCL) idalandira PhD mu Biotechnology. Ntchito yake imaphatikizapo kugwiritsira ntchito ma nanoparticles okhala ndi mamolekyu osiyanasiyana okonda zachilengedwe, kuphunzira kachitidwe kachitidwe ndikupanga ntchito zothandiza.
Dwivedi, Ramya. (2020, Okutobala 23). Vitamini C ndi COVID-19: Ndemanga. Nkhani zachipatala. Kubwezeredwa kuchokera ku https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx pa Novembara 12, 2020.
Dwivedi, Ramya. "Vitamini C ndi COVID-19: Ndemanga." Nkhani zachipatala. Novembala 12, 2020. .
Dwivedi, Ramya. "Vitamini C ndi COVID-19: Ndemanga." Nkhani zachipatala. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Idapezeka pa Novembara 12, 2020).
Dwivedi, Ramya. 2020. "Vitamini C ndi COVID-19: Ndemanga." News-Medical, idasakatulidwa pa Novembara 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
M'mafunsowa, Pulofesa Paul Tesar ndi Kevin Allan adafalitsa nkhani m'manyuzipepala azachipatala za momwe mpweya wocheperako umawonongera ubongo.
M'mafunso awa, Dr. Jiang Yigang adakambirana za ACROBiosystems ndi zoyesayesa zake polimbana ndi COVID-19 ndikupeza katemera.
Muzoyankhulana izi, News-Medical idakambirana za chitukuko ndi mawonekedwe a ma antibodies a monoclonal ndi David Apiyo, woyang'anira wamkulu wa ntchito ku Sartorius AG.
News-Medical.Net imapereka zidziwitso zachipatalazi molingana ndi izi. Chonde dziwani kuti chidziwitso chachipatala chomwe chili patsamba lino chimangogwiritsidwa ntchito kuthandizira osati kubwezeretsa ubale pakati pa odwala ndi madokotala komanso malangizo azachipatala omwe angapereke.
Timagwiritsa ntchito makeke kuti tikulitse zomwe mumakumana nazo. Mukapitiliza kuyang'ana webusayiti iyi, mukuvomera kugwiritsa ntchito makeke. Zambiri.