Ubushakashatsi bwakozwe muri Danemark bwerekanye ko ku barwayi bafite ubukana bukabije bw’indwara zidakira zifata indwara zidakira (COPD), amoxicilline yonyine ifite ibisubizo byiza kuruta amoxicilline ihujwe n’indi antibiyotike, aside clavulanic.
Ubushakashatsi bwiswe "Ubuvuzi bwa Antibiotique mu Kwiyongera gukabije kwa COPD: Ibisubizo by’abarwayi ba Amoxicillin na Amoxicillin / Clavulanic Acide-Data yavuye ku barwayi 43,636" byasohotse mu kinyamakuru cy’ubushakashatsi bw’ubuhumekero.
Kwiyongera gukabije kwa COPD ni ibintu byerekana ibimenyetso byumurwayi bikabije. Kubera ko ibyo kwiyongera mubisanzwe bifitanye isano n'indwara ziterwa na bagiteri, kuvura antibiyotike (imiti yica bagiteri) biri murwego rwo kwitaho.
Muri Danimarike, hari uburyo bubiri bukoreshwa na antibiotique bushobora gukoreshwa mu kuvura ubwo buryo bukabije. Imwe ni 750 mg amoxicilline inshuro eshatu kumunsi, indi ni 500 mg amoxicillin hiyongereyeho 125 mg clavulanic aside, nayo inshuro eshatu kumunsi.
Amoxicillin na acide clavulanic byombi ni beta-lactam, ari antibiyotike ikora ibangamira umusaruro w’urukuta rwa bagiteri, bityo ikica bagiteri.
Ihame ryibanze ryo guhuza antibiyotike zombi ni uko aside clavulanic ikora neza muburyo butandukanye bwa bagiteri. Nyamara, kuvura hamwe na amoxicilline yonyine bivuze ko antibiyotike imwe ishobora gutangwa ku kigero kinini, amaherezo ishobora kwica bagiteri neza.
Noneho, itsinda ryabashakashatsi bo muri Danemarke bagereranije neza ibyavuye muri ubu buryo bubiri bwo kuvura ubukana bukabije bwa COPD.
Abashakashatsi bifashishije imibare yavuye mu gitabo cya COPD cyo muri Danemarike, ifatanije n’amakuru yaturutse mu bindi bihugu byiyandikishije mu gihugu, kugira ngo bamenye abarwayi 43.639 bafite ibibazo bikabije bakiriye bumwe mu buryo bubiri bwasesenguwe. By'umwihariko, abantu 12.915 bafashe amoxicilline bonyine naho abantu 30.721 bafata imiti ikomatanya. Twabibutsa ko nta n'umwe mu barwayi wasesenguwe wari mu bitaro kubera ubukana bwa COPD, ibyo bikaba byerekana ko icyo gitero kitari gikomeye.
Ugereranije no guhuza amoxicilline na acide clavulanic, kuvura hamwe na amoxicilline yonyine birashobora kugabanya ibyago byo kwandura ibitaro byatewe n'umusonga cyangwa impfu zose zitera 40% nyuma yiminsi 30. Amoxicillin yonyine nayo ifitanye isano no kugabanya 10% ibyago byo kuba mubitaro bitari umusonga cyangwa urupfu no kugabanuka kwa 20% ibyago byo kuba mubitaro cyangwa urupfu.
Kuri izi ngamba zose, itandukaniro riri hagati yubuvuzi bwombi rifite imibare. Isesengura ry’imibare yinyongera rishobora kubona ibisubizo bihamye.
Abashakashatsi baranditse bati: "Twabonye ko ugereranije na AMC [amoxicillin wongeyeho aside clavulanic], abarwayi ba AECOPD [COPD exacerbation] bavuwe na AMX [amoxicillin bonyine] bafite ibyago byo kuba mu bitaro cyangwa bapfa umusonga mu minsi 30.
Iri tsinda riratekereza ko imwe mu mpamvu zishobora gutera iki gisubizo ari itandukaniro rya dosiye hagati ya antibiyotike ebyiri.
Baranditse bati: "Iyo bikozwe ku kigero kimwe, AMC [guhuza] ntibishobora kuba munsi ya AMX [amoxicillin yonyine]".
Muri rusange, isesengura “rishyigikira ikoreshwa rya AMX nk'ubuvuzi bwa antibiyotike bwatoranijwe ku barwayi bafite AECOPD,” abashakashatsi bashoje bavuga ko “kongeramo aside clavulanic kuri amoxicilline ntaho bihuriye n'ibisubizo byiza.”
Abashakashatsi bavuga ko imbogamizi nyamukuru y’ubushakashatsi ari ingaruka z’urujijo bitewe n’ibimenyetso-mu yandi magambo, abantu basanzwe bameze nabi bashobora guhabwa imiti ivura. Nubwo isesengura ry’imibare y’abashakashatsi rigerageza gusobanura iki kintu, biracyashoboka ko itandukaniro mbere yo kuvurwa ryasobanuye bimwe mubisubizo.
Uru rubuga rwose ni amakuru namakuru yamakuru yerekeye indwara. Ntabwo itanga inama zubuvuzi, gusuzuma cyangwa kuvura. Ibirimo ntabwo bisimburwa ninama zubuvuzi zumwuga, gusuzuma cyangwa kuvura. Niba ufite ikibazo kijyanye n'ubuvuzi, burigihe ushakishe inama kwa muganga cyangwa undi mutanga wujuje ibyangombwa. Ntukirengagize inama z'ubuvuzi cyangwa gutinda gushaka inama z'ubuvuzi kubera ibyo wasomye kururu rubuga.