Mu myaka mirongo ibiri, albendazole yatanzwe muri gahunda nini yo kuvura lymphatic filariasis. Isubiramo rya Cochrane ryasuzumye imikorere ya albendazole muri lymphatic filariasis.
Lymphatic filariasis n'indwara iterwa n'umubu ikunze kuboneka mu turere dushyuha no mu turere dushyuha twatewe n'indwara ya parasitike. Nyuma yo kwandura, liswi ikura ikuze kandi ikabana na microfilariae (mf). MF noneho ikusanywa n imibu mugihe irisha amaraso, kandi infection irashobora kwanduza undi muntu.
Indwara irashobora gupimwa mugupimisha MF (microfilaraemia) cyangwa antigens ya parasite (antigenemia) cyangwa muguhitamo inyo zikuze zikuze na ultrasound.
Ishami ry'Umuryango w'Abibumbye ryita ku Buzima (OMS) rirasaba kuvura abaturage bose buri mwaka byibuze imyaka itanu. Intandaro yo kuvura ni ihuriro ryibiyobyabwenge bibiri: albendazole na microfilaricidal (antimalarial) ibiyobyabwenge diethylcarbamazine (DEC) cyangwa ivermectin.
Albendazole buri gihembwe birasabwa mubice aho loiasis yanduye, kandi DEC cyangwa ivermectin ntibigomba gukoreshwa kubera ibyago byingaruka zikomeye.
Ivermectin na DEK byombi byahanaguyeho kwandura mf vuba kandi birashobora kubuza ko byongera kubaho. Ariko, umusaruro wa mf uzakomeza kubera guhura kwabantu bakuru. Albendazole yafatwaga nk'ubuvuzi bwa lymphatic filariasis kuko ubushakashatsi bwerekanye ko dosiye nyinshi yatanzwe mu byumweru byinshi byaviriyemo ingaruka zikomeye zerekana urupfu rw'inyo zikuze.
Raporo idasanzwe y’inama ya OMS yaje kwerekana ko albendazole igira ingaruka ku bwicanyi cyangwa fungiside ku bantu bakuru. Mu 2000, GSK yatangiye gutanga albendazole muri gahunda yo kuvura Lymphatic Filariasis.
Ibizamini byemewe byamavuriro (RCTs) byasuzumye imikorere n'umutekano bya albendazole wenyine cyangwa ifatanije na ivermectin cyangwa DEC. Ibi byakurikiranwe no gusuzuma byinshi kuri RCTs hamwe namakuru yo kureba, ariko ntibisobanutse niba albendazole hari inyungu muri lymphatic filariasis.
Dukurikije ibyo, isuzuma rya Cochrane ryasohowe mu 2005 ryaravuguruwe kugira ngo harebwe ingaruka za albendazole ku baturage no ku baturage bafite lymphatic filariasis.