Mu myaka mirongo ibiri, albendazole yatanzwe muri gahunda nini yo kuvura lymphatic filariasis. Isuzuma rya Cochrane riherutse gusuzuma imikorere ya albendazole mu kuvura lymphatic filariasis.
Lymphatic filariasis n'indwara ikunze kugaragara mu turere dushyuha no mu turere dushyuha, yanduza imibu kandi iterwa na virusi ya parasitike. Nyuma yo kwandura, liswi ikura ikuze kandi igashyingiranwa ikora microfilariae (MF). Umubu uhita ufata MF mugihe urya amaraso, kandi infection irashobora kwanduza undi muntu.
Indwara irashobora gupimwa mugupima ikwirakwizwa rya MF (microfilamentemia) cyangwa antigene ya parasite (antigenemia) cyangwa mukumenya inyo zikomeye zikuze na ultrasonography.
Ishami ry'Umuryango w'Abibumbye ryita ku Buzima (OMS) rirasaba kuvura abaturage bose buri mwaka byibuze imyaka itanu. Intandaro yo kuvura ni ihuriro ryibiyobyabwenge bibiri: albendazole na microfilaricidal (antifilariasis) ibiyobyabwenge diethylcarmazine (DEC) cyangwa ivermectin.
Albendazole yonyine irasabwa gukoreshwa mu mwaka wa kabiri mu bice aho indwara ya Roa ikwirakwizwa, aho DEC cyangwa ivermectin idakwiye gukoreshwa kubera ingaruka z’ingaruka zikomeye.
Ivermectin na DEC byombi byahanaguye vuba ubwandu bwa MF kandi bihagarika kugaruka kwayo. Nyamara, umusaruro wa MF uzakomeza kubera guhura kwabantu bakuru. Albendazole yatekerejweho kuvura lymphatic filariasis nyuma y’ubushakashatsi bwerekanye ko dosiye nyinshi zatanzwe mu byumweru byinshi zatumye habaho ingaruka zikomeye zerekana urupfu rw’inyo zikuze.
Inama idasanzwe ya OMS yaje kwerekana ko albendazole yishe cyangwa itera ibikorwa byo kurwanya inyo zikuze. Mu 2000, GlaxoSmithKline yatangiye gutanga albendazole mumishinga yo kuvura lymphatic filariasis.
Ibizamini byemewe byamavuriro (RCTs) byasuzumye imikorere n'umutekano bya albendazole wenyine cyangwa ifatanije na ivermectin cyangwa DEC. Icyakurikiyeho, habaye isuzuma rinonosoye ryibigeragezo byateganijwe hamwe namakuru yo kureba, ariko ntibisobanutse niba albendazole hari inyungu muri lymphatic filariasis.
Dukurikije ibyo, isuzuma rya Cochrane ryasohowe mu 2005 ryaravuguruwe kugira ngo harebwe ingaruka za albendazole ku barwayi n’abaturage bafite lymphatic filariasis.
Isuzuma rya Cochrane ni isubiramo ritunganijwe rigamije kumenya, gusuzuma, no kuvuga muri make ibimenyetso byose bifatika byujuje ibisabwa mbere yo gusubiza ikibazo cyubushakashatsi. Cochrane isubirwamo ivugururwa uko amakuru mashya aboneka.
Uburyo bwa Cochrane bugabanya kubogama mubikorwa byo gusuzuma. Ibi bikubiyemo gukoresha ibikoresho byo gusuzuma ingaruka zo kubogama mubigeragezo kugiti cyawe no gusuzuma ukuri (cyangwa ubuziranenge) bwibimenyetso kuri buri gisubizo.
Igitekerezo cya Cochrane cyavuguruwe "Albendazole wenyine cyangwa ifatanije na microfilaricidal agent muri lymphatic filariasis" cyasohowe muri Mutarama 2019 nitsinda rya Cochrane Indwara zanduza hamwe na COUNTDOWN Consortium.
Ibyavuye mu nyungu zirimo ubushobozi bwo kwanduza (ubwinshi bwa MF n'ubucucike), ibimenyetso byanduza inyo zikuze (ubwinshi bwa antigenemia hamwe n'ubucucike, hamwe na ultrasound gutahura inyo zikuze), no gupima ibintu bibi.
Abanditsi bagerageje gukoresha ubushakashatsi bwa elegitoronike kugirango babone ibigeragezo byose bijyanye kugeza muri Mutarama 2018, batitaye ku mvugo cyangwa uko byatangajwe. Abanditsi babiri basuzumye ubwigenge ubushakashatsi bwashyizwemo, basuzuma ibyago byo kubogama, bakuramo amakuru yikigereranyo.
Isubiramo ryarimo ibigeragezo 13 hamwe nabitabiriye 8713. Hakozwe meta-gusesengura ubwinshi bwa parasite n'ingaruka zakozwe kugirango bapime ingaruka zo kuvura. Tegura imbonerahamwe yo gusesengura ibisubizo bya parasite, kuko raporo mbi bivuze ko amakuru adashobora guhuzwa.
Abanditsi basanze albendazole yonyine cyangwa ifatanije na microfilaricide ntacyo byahinduye ku bwiyongere bwa MF hagati y'ibyumweru bibiri n'amezi 12 nyuma yo kuvurwa (ibimenyetso byujuje ubuziranenge).
Ntabwo bari bazi niba hari ingaruka ku bucucike bwa mf mumezi 1-6 (ibimenyetso byujuje ubuziranenge) cyangwa kumezi 12 (ibimenyetso byujuje ubuziranenge).
Albendazole wenyine cyangwa ifatanije na microfilaricide ntacyo byahinduye ku bwiyongere bwa antigenemia mu mezi 6-12 (ibimenyetso byujuje ubuziranenge).
Abanditsi ntibari bazi niba hari ingaruka ku bucucike bwa antigen hagati y'amezi 6 na 12 y'amavuko (ibimenyetso bidafite ireme). Albendazole yongeyeho microfilaricide birashoboka ko ntacyo byahinduye ku bwiganze bw’inyo zikuze zagaragajwe na ultrasound mu mezi 12 (ibimenyetso simusiga).
Iyo ikoreshejwe wenyine cyangwa ikomatanyije, albendazole ntacyo yahinduyeho kumubare wabantu bavuga ibintu bibi (ibimenyetso byujuje ubuziranenge).
Isuzuma ryabonye ibimenyetso bihagije byerekana ko albendazole, yonyine cyangwa ifatanije na microfilaricide, nta ngaruka nini cyangwa bigira ku kurandura burundu microfilariae cyangwa helminths zikuze mu mezi 12 yo kwivuza.
Urebye ko uyu muti uri muri politiki y’ibanze, kandi ko Ishami ry’Umuryango w’abibumbye ryita ku buzima ubu na ryo risaba ko habaho imiti itatu, ntibishoboka ko abashakashatsi bazakomeza gusuzuma albendazole ifatanije na DEC cyangwa ivermectin.
Ariko, mubice byanduye Roa, birasabwa gusa albendazole. Kubwibyo, gusobanukirwa niba ibiyobyabwenge bikora muri aba baturage bikomeje kuba ibya mbere mu bushakashatsi.
Imiti yica udukoko twinshi hamwe na gahunda yigihe gito yo gusaba irashobora kugira ingaruka zikomeye kuri gahunda yo kurandura filariyasi. Kimwe muri ibyo biyobyabwenge kuri ubu kiri mu majyambere kandi cyasohotse muri blog ya BugBitten iherutse.
Mugukomeza gukoresha uru rubuga, wemera kumasezerano yacu yo gukoresha, umurongo ngenderwaho wabaturage, itangazo ryibanga na Politiki ya kuki.