Streptomycine niyo antibiyotike yambere yavumbuwe mu cyiciro cya aminoglycoside kandi ikomoka kuri actinobacterium yaStreptomycesubwoko1. Ikoreshwa cyane mu kuvura indwara zikomeye ziterwa na bagiteri ziterwa na Gram-negative na Gram-positif, harimo igituntu, indwara ya endocardial na meningeal n'icyorezo. Nubwo bizwi ko uburyo bwibanze bwibikorwa bya streptomycine ari ukubuza intungamubiri za poroteyine guhuza ribosome, uburyo bwo kwinjira muri bagiteri ntiburasobanuka neza.

Umuyoboro wa Mechanosensitif yimyitwarire nini (MscL) numuyoboro wa bagiteri wabitswe cyane mikorosensitivite yumva neza impagarara muri membrane2. Uruhare rwa physiologique rwa MscL ni urw'ibikoresho byo kurekura byihutirwa byinjira ku kugabanuka gukabije kwa osmolarite y'ibidukikije (hypo-osmotic downshock)3. Mugihe cya hypo-osmotic, amazi yinjira muri selile itera kubyimba, bityo byongera impagarara muri membrane; Amarembo ya MscL asubiza iyi mpagarara ikora pore nini ya 30 Å4, bityo kwemerera kurekura byihuse ibisubizo no gukiza selile muri lysis. Kubera ubunini bunini bwa pore, Gate ya MscL irateganijwe neza; imvugo yumuyoboro wa MscL ufunguye nabi, ifungura munsi yuburemere busanzwe, itera gukura kwa bagiteri buhoro cyangwa no gupfa kwakagari5.

Imiyoboro ya mikorobe yunvikana yatanzwe nkintego nziza yibiyobyabwenge bitewe nuruhare runini bagize muri physiologiya ya bagiteri no kutagira homologues yamenyekanye mubinyabuzima byo hejuru.6. Twakoze rero ecran-yinjiza cyane (HTS) dushakisha ibice bizabuza gukura kwa bagiteri muburyo bushingiye kuri MscL. Igishimishije, mubyamamare twasanze antibiyotike enye zizwi, murizo zikoreshwa cyane aminoglycoside antibiotique streptomycine na spectinomycine.

Imbaraga za streptomycine ziterwa nimvugo ya MscL mugukura no kugerageza kubahomuri vivo.Turatanga kandi gihamya yerekana ihinduka ryibanze ryibikorwa bya MscL na dihydrostreptomycin mubushakashatsi bwa clamp clampmuri vitro. Uruhare rwa MscL mu nzira y'ibikorwa bya streptomycine ntirwerekana gusa uburyo bushya bwerekana uburyo iyi molekile nini kandi nini cyane ya polarike itabona uburyo bwo kugera mu kagari ku gipimo gito, ariko kandi ni ibikoresho bishya byo guhindura imbaraga za antibiyotike zisanzwe zizwi kandi zishobora kuba.