Streptomycine Sulfate: Antibiyotike ikomeye ya Aminoglycoside mu buvuzi bwa none

Mu rwego rwa antibiyotike, Streptomycin Sulfate igaragara nka aminoglycoside yizewe kandi ikomeye yagize uruhare runini mu kurwanya indwara ziterwa na bagiteri. Uru ruganda rwinshi, hamwe nuburyo bwihariye bwibikorwa, rukomeje kuba urufatiro mu buvuzi bwo kurwanya indwara ku isi.

Streptomycine Sulfate ni iki?

Streptomycin Sulfate, ifite CAS nimero 3810-74-0, ni antibiyotike ya aminoglycoside ikomoka kuri Streptomyces griseus, bagiteri yubutaka. Irangwa nubushobozi bwayo bwo guhagarika intungamubiri za poroteyine mu ngirabuzimafatizo za bagiteri, bigahagarika neza imikurire yazo no kwigana. Iyi antibiyotike iraboneka mu byiciro bitandukanye, harimo na USP Grade, yemeza ko ifite isuku kandi ikwiriye gukoreshwa mu buvuzi.

Akamaro na Porogaramu

Akamaro ka Streptomycin Sulfate iri mubikorwa byayo byinshi birwanya Gram-mbi na bagiteri zimwe na zimwe za Gram-nziza. Ifite akamaro cyane mu kuvura igituntu, indwara idakira yandura ifata ibihaha ndetse n'ibindi bice by'umubiri. Uruhare rwayo mu kuvura igituntu rwagize uruhare runini, akenshi rukaba ari kimwe mu bigize imiti ikomatanya kugira ngo irusheho gukora neza no gukumira iterambere.

Byongeye kandi, Streptomycin Sulfate isanga ibisabwa mubuvuzi bwamatungo, ubuhinzi, hamwe nubushakashatsi. Mu buhinzi, ifasha kurwanya indwara za bagiteri mu bihingwa n’amatungo, kuzamura umusaruro w’ibihingwa n’ubuzima bw’inyamaswa. Abashakashatsi bifashisha kandi Streptomycin Sulfate kugira ngo bige ku ngirabuzima fatizo za bagiteri, kurwanya antibiyotike, ndetse no gukoresha poroteyine.

Uburyo bwibikorwa

Uburyo bukoreshwa na Streptomycine Sulfate bukoresha ingaruka za antibacterial zirimo kubangamira intungamubiri za poroteyine. By'umwihariko, ihuza na bagiteri ribosome, igira ingaruka ku guhitamo kwimura RNA (tRNA) mugihe cyo guhindura. Uku guhambira guhungabanya ukuri kwa decoding mRNA na ribosome, biganisha ku gukora poroteyine zidakora cyangwa zaciwe. Kubera iyo mpamvu, selile ya bagiteri ntishobora gukomeza imirimo yingenzi, amaherezo bikaviramo gupfa.

Igishimishije, Streptomycin Kurwanya sulfate akenshi ikarita yerekana ihinduka ryimiterere muri poroteyine ya ribosomal S12. Izi mpinduka za mutant zerekana imbaraga zivangura mugihe cyo gutoranya tRNA, bigatuma zidashobora kwibasirwa ningaruka za antibiotique. Gusobanukirwa nuburyo bwo guhangana ningirakamaro mugutegura ingamba nshya zo kuvura no kurwanya iterabwoba rigenda ryiyongera rya antibiyotike.

Kubika no Gukemura
Birakwiye
kubika no gufata neza Streptomycin Sulfate ni ngombwa kugirango ikomeze gukora neza n'umutekano. Iyi antibiyotike igomba kubikwa ku bushyuhe buri hagati ya 2-8 ° C (36-46 ° F) mu kintu gifunze, kure y’ubushuhe n’umucyo. Ibi bintu bifasha kubungabunga urwego rwimitekerereze no kwirinda kwangirika.

Isoko no Kuboneka

Streptomycin Sulfate iraboneka cyane ku isoko ryimiti, itangwa nababikora benshi nabatanga isoko kwisi yose. Ibiciro birashobora gutandukana bitewe nimpamvu nkurwego, ubuziranenge, nubunini byateganijwe. Sulfate yo mu rwego rwohejuru ya Streptomycin, nk'iyujuje ubuziranenge bwa USP, itegeka igihembo kubera igeragezwa ryayo rikomeye kandi ryizeza ubuziranenge.

Ibizaza

Nubwo imaze igihe kinini ikoreshwa, Streptomycin Sulfate ikomeje kuba antibiyotike ikomeye mu kurwanya indwara ziterwa na bagiteri. Mugihe abashakashatsi bakomeje gushakisha antibiyotike nshya nuburyo bwo kuvura, uruhare rwa Streptomycine Sulfate rushobora guhinduka. Nyamara, ibikorwa byayo byashizweho, ibikorwa byagutse, hamwe nigiciro gito ugereranije bituma ihitamo agaciro mumavuriro menshi nubushakashatsi.

Mu gusoza, Streptomycin Sulfate ni gihamya yimbaraga za antibiotique mubuvuzi bwa kijyambere. Ubushobozi bwayo bwo guhagarika intungamubiri za poroteyine za bagiteri no kurwanya indwara zakijije ubuzima butabarika kandi bukomeje kuba umusingi w’ubuvuzi bwo kurwanya indwara. Hamwe n'ubushakashatsi bukomeje gukorwa ndetse no guteza imbere antibiyotike nshya, nta gushidikanya ko umurage wa Streptomycin Sulfate uzihanganira, uzagira uruhare mu bikorwa byo kurwanya indwara zanduza.