Urukwavu coccidiose nindwara igaragara hose iterwa nubwoko bumwe cyangwa bwinshi bwubwoko 16 bwubwoko bwa apicomplexanEimeria stiedae.^1-4Ibimenyetso rusange byindwara byindwara birangwa no gucika intege, kugabanya kurya ibiryo, impiswi cyangwa impatwe, kwaguka kwumwijima, asite, icterus, guta inda, nurupfu.³Coccidiose mu nkwavu irashobora kwirindwa no kuvurwa hakoreshejwe ibiyobyabwenge.^1,3,5,6Toltrazuril (Tol), 1- [3-methyl-4-.Igishushanyo 1), ni ikomatanya triazinetrione ikoreshwa cyane mukurinda no kurwanya coccidiose.^7-10Ariko, kubera kutagira amazi meza, Tol biragoye kwinjizwa numuyoboro wa gastrointestinal (GI). Ingaruka zamavuriro ya Tol zaragabanutse kubera gukemuka kwayo muri GI.

Igishushanyo 1 Imiterere yimiti ya toltrazuril.

Amazi mabi yo mumazi ya Tol yatsinzwe nubuhanga bumwe na bumwe, nko gutatana gukomeye, imbaraga za ultrafine, na nanoemulsion.^11-13Nubu buryo bukoreshwa muburyo bwo kongera imbaraga, gukwirakwiza Tol gukomeye byongereye imbaraga za Tol inshuro 2000,¹¹ibyo bikaba byerekana ko gukemura kwayo bigikenewe kongererwa imbaraga binyuze mubindi buhanga. Byongeye kandi, gutatanya gukomeye hamwe na nanoemuliyoni ntibihinduka kandi ntibyoroshye kubika, mugihe ingufu za ultrafine zikenera ibikoresho bihanitse kugirango bitange umusaruro.

cy-cyclodextrin (β-CD) irakoreshwa cyane kubera ubunini bwayo bwihariye, imikorere y’ibiyobyabwenge, hamwe no kongera ibiyobyabwenge, gukomera, hamwe na bioavailable.^14,15Kubijyanye nuburyo bugenzurwa, CD-CD yanditse mumasoko menshi ya farumasi, harimo na Pharmacopoeia yo muri Amerika / Imiterere yigihugu, Pharmacopoeia yu Burayi, hamwe na Codex yubuyapani.^16,17Hydroxypropyl - β-CD (HP-β-CD) ni hydroxyalkyl β-CD ikomokaho yizwe cyane mu ruganda rwinjizwamo ibiyobyabwenge kubera ubushobozi bwarwo hamwe n’amazi menshi.^18-21Ubushakashatsi bw’uburozi bwatanze raporo ku mutekano wa HP-β-CD mu mitsi yinjira mu kanwa no mu kanwa ku mubiri w'umuntu,²²na HP-β-CD yakoreshejwe muburyo bwo kuvura kugirango ikemure ibibazo bidakemutse kandi byongere bioavailability.²³

Ibiyobyabwenge byose ntabwo bifite ibintu bigomba gukorwa muburyo bukomeye hamwe na HP-β-CD. Tol wasangaga afite imitungo ishingiye kumubare munini wo gukora ubushakashatsi. Kugirango hongerwe imbaraga hamwe na bioavailable ya Tol mugushyiramo urwego rugizwe na HP-β-CD, toltrazuril - hydroxypropyl - β-cyclodextrin igizwe (Tol-HP-β-CD) yateguwe nuburyo bukurura ibisubizo muri ubu bushakashatsi, kandi buke -umukinyi wa chromatografiya (TLC), Fourier transform infrared (FTIR) spectroscopy, hamwe na magnetiki resonance (NMR) spekitroscopi yakoreshejwe kugirango iranga ibyabonetse Tol-HP-β-CD. Umwirondoro wa farumasi ya Tol na Tol-HP-β-CD mu nkwavu nyuma yubuyobozi bwo munwa wagereranijwe muri vivo.