Vitamine C, izwi kandi nka acide acorbike, ni intungamubiri zingenzi zishonga mu mazi. Abantu hamwe nandi matungo amwe (nka primates, ingurube) biterwa na vitamine C mugutunga intungamubiri zimbuto n'imboga (urusenda rutukura, orange, strawberry, broccoli, imyembe, indimu). Uruhare rushobora kuba rwa vitamine C mu gukumira no kunoza indwara rwamenyekanye mu buvuzi.
Acide ya Ascorbic ningirakamaro mugukingira indwara. Ifite anti-inflammatory, immunomodulatory, antioxidant, anti-trombose hamwe na anti-virusi.
Vitamine C isa nkaho ishoboye kugenzura igisubizo cyabakiriye syndrome ikabije yubuhumekero coronavirus 2 (SARS-CoV-2). Coronavirus nimpamvu itera indwara ya coronavirus ya 2019 (COVID-19), cyane cyane iri mubihe bikomeye. Mubitekerezo biherutse gusohoka muri Preprints *, Patrick Holford n'abandi. Yakemuye uruhare rwa vitamine C nk'ubuvuzi bufasha kwandura indwara z'ubuhumekero, sepsis na COVID-19.
Iyi ngingo iraganira ku ruhare rwa vitamine C ishobora gukumira icyiciro gikomeye cya COVID-19, indwara zandurira mu myanya y'ubuhumekero n'izindi ndwara zanduza. Biteganijwe ko inyongera ya Vitamine C izaba imiti igabanya ubukana cyangwa ivura indwara ya COVID-19 ikosora amakosa yatewe n'indwara, kugabanya imihangayiko ya okiside, kongera umusaruro wa interferon no gushyigikira ingaruka zo kurwanya indwara ya glucocorticoide.
Kugirango ugumane urugero rwa plasma rusanzwe mubantu bakuru kuri 50 µmol / l, vitamine C ya vitamine C kubagabo ni 90 mg / d naho kubagore 80 mg / d. Ibi birahagije kugirango wirinde ibisebe (indwara iterwa no kubura vitamine C). Nyamara, uru rwego ntiruhagije kugirango wirinde kwandura virusi no guhangayika.
Kubera iyo mpamvu, Umuryango w’imirire mu Busuwisi urasaba ko hongerwa buri muntu mg 200 za vitamine C-kugira ngo yuzuze icyuho cy’imirire y’abaturage muri rusange, cyane cyane abakuze bafite imyaka 65 nayirenga. Iyi nyongera yagenewe gushimangira sisitemu yumubiri. "
Mugihe cyimiterere yumubiri, vitamine C ya serumu yumuntu igabanuka vuba. Serumu vitamine C irimo abarwayi bari mu bitaro ni ≤11µmol / l, kandi benshi muribo barwaye indwara zandurira mu myanya y'ubuhumekero, sepsis cyangwa COVID-19 ikabije.
Ubushakashatsi butandukanye bwakozwe hirya no hino ku isi bwerekana ko vitamine C nkeya ikunze kugaragara ku barwayi barwariye mu bitaro barwaye indwara z’ubuhumekero, umusonga, sepsis na COVID-19-ibisobanuro bishoboka cyane ni ukongera metabolike.
Isesengura rya meta ryagaragaje ibi bikurikira: 1) Kwiyongera kwa Vitamine C birashobora kugabanya cyane ibyago byo kwandura umusonga, 2) Iperereza ryakozwe nyuma y’urupfu nyuma yo gupfa kwa COVID-19 ryerekanye umusonga wa kabiri, na 3) Kubura Vitamine C ni byo byatuye abaturage bose hamwe umusonga 62%.
Vitamine C igira ingaruka zikomeye za homeostatike nka antioxydeant. Birazwi ko bifite ibikorwa byica virusi itaziguye kandi birashobora kongera umusaruro wa interferon. Ifite uburyo bukoreshwa muburyo bwo kwirinda indwara. Vitamine C igabanya ubwoko bwa ogisijeni ikora (ROS) no gutwika kugabanya imikorere ya NF-κB.
SARS-Co.
Icyiciro gikomeye cya COVID-19 (mubisanzwe icyiciro cyica) kibaho mugihe cyo kubyara cyane cytokine nziza na chemokine. Ibi byatumye habaho iterambere ryo kunanirwa kwingingo nyinshi. Bifitanye isano no kwimuka no kwegeranya kwa neutrophile muri interstitium y'ibihaha no mu cyuho cya bronchoalveolar, icya nyuma kikaba ari ikintu cy'ingenzi kigena ARDS (Acute Respiratory Distress Syndrome).
Ubwinshi bwa acide acorbike muri glande ya adrenal na glande ya pituito yikubye inshuro eshatu kugeza ku icumi ugereranije nizindi ngingo zose. Mugihe cyimyitwarire ya physiologique (ACTH stimulation) harimo kwandura virusi, vitamine C isohoka muri cortex ya adrenal, bigatuma plasma yiyongera inshuro eshanu.
Vitamine C irashobora kongera umusaruro wa cortisol, ikanongerera imbaraga anti-inflammatory na endothelial selile zo kurinda glucocorticoide. Exogenous glucocorticoid steroid niyo miti yonyine yagaragaye ko ivura COVID-19. Vitamine C ni imisemburo itera imbaraga nyinshi, igira uruhare runini muguhuza ibibazo bya adrenal cortex (cyane cyane sepsis) no kurinda endotelium kwangirika kwa okiside.
Urebye ingaruka za vitamine C ku mbeho igabanya igihe, ubukana ninshuro ya vitamine C ifata ibicurane bishobora kugabanya inzibacyuho kuva kwandura byoroheje kugeza mugihe gikomeye cya COVID-19.
Byagaragaye ko inyongera ya vitamine C ishobora kugabanya igihe cyo kumara muri ICU, kugabanya igihe cyo guhumeka cy’abarwayi barembye cyane bafite COVID-19, kandi bikagabanya imfu z’abarwayi ba sepsis bakeneye kuvurwa na vasopressor.
Bitewe nuburyo butandukanye bwimpiswi, amabuye yimpyiko no kunanirwa kwimpyiko mugihe cyinshi, abanditsi baganiriye kumutekano wogutanga umunwa no kwinjiza imitsi ya vitamine C. Birashoboka ko hashobora gutangwa urugero rwigihe gito cya 2-8 g / kumunsi. witonze wirinde urugero rwinshi kubantu bafite amateka yamabuye yimpyiko cyangwa indwara zimpyiko). Kubera ko ishobora gukama amazi, irashobora gusohoka mu masaha make, bityo inshuro ya dosiye ni ngombwa kugirango igabanye amaraso ahagije mugihe cyanduye.
Nkuko twese tubizi, vitamine C irashobora kwirinda kwandura no kunoza ubudahangarwa bw'umubiri. Cyane cyane kuvuga ku cyiciro gikomeye cya COVID-19, vitamine C igira uruhare runini. Igabanya-kugabanya umuyaga wa cytokine, irinda endotelium kwangirika kwa okiside, igira uruhare runini mu gusana ingirangingo, kandi igafasha ubudahangarwa bw'umubiri kwandura.
Umwanditsi arasaba ko inyongera za vitamine C zigomba kongerwaho buri munsi kugira ngo zishishikarize amatsinda afite ibyago byinshi bifite impfu nyinshi za COVID-19 no kubura vitamine C. Bagomba guhora bemeza ko vitamine C ihagije kandi ikongera urugero mugihe virusi yanduye, kugeza kuri 6-8 g / kumunsi. Ubushakashatsi butari buke bwa vitamine C ziterwa na vitamine C burakomeje ku isi hose kugira ngo hemezwe uruhare rwayo mu kugabanya COVID-19 no kumva neza uruhare rwayo nk'ubushobozi bwo kuvura.
Ibicapiro bizatangaza raporo yubumenyi yambere itigeze isuzumwa n’urungano, bityo rero ntigomba gufatwa nkicyemezo, kiyobora imyitozo yubuvuzi / imyitwarire ijyanye nubuzima cyangwa ifatwa nkamakuru yuzuye.
Etique sisitemu, gutwika, intera, impyiko, indwara zimpyiko, kunanirwa nimpyiko, impfu, imirire, guhagarika umutima, icyorezo, umusonga, ubuhumekero, SARS-CoV-2, scurvy, Sepsis, indwara zikomeye z’ubuhumekero, syndrome ikaze y’ubuhumekero, strawberry, stress, syndrome, imboga, virusi, vitamine C
Ramya afite PhD. Laboratoire y’igihugu ya Pune (CSIR-NCL) yakiriye PhD muri Biotechnology. Mubikorwa bye harimo gukora nanoparticles hamwe na molekile zitandukanye zinyungu zibinyabuzima, kwiga sisitemu yo kubyitwaramo no kubaka ibikorwa byingirakamaro.
Dwivedi, Ramya. (2020, 23 Ukwakira). Vitamine C na COVID-19: Isubiramo. Amakuru yubuvuzi. Yakuwe kuri https://www.amakuru-medical.net/amakuru/20201023/Vitamine-C-kandi-COVID-19-A-Gusubiramo.aspx ku ya 12 Ugushyingo 2020.
Dwivedi, Ramya. "Vitamine C na COVID-19: Isubiramo." Amakuru yubuvuzi. Ku ya 12 Ugushyingo 2020.
Dwivedi, Ramya. "Vitamine C na COVID-19: Isubiramo." Amakuru yubuvuzi. https://www.amakuru-amakuru-yamakuru.net/amakuru/20201023/Vitamine-C-kandi-COVID-19-A-Gusubiramo.aspx. (Yemezwa ku ya 12 Ugushyingo 2020).
Dwivedi, Ramya. 2020. "Vitamine C na COVID-19: Isubiramo." Amakuru-Ubuvuzi, yashakishijwe ku ya 12 Ugushyingo 2020,
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