Ongororo yeDanish yakaratidza kuti kune varwere vane acute exacerbation ye chronic obstructive pulmonary disease (COPD), amoxicillin yega ine mhedzisiro iri nani pane amoxicillin yakasanganiswa nerimwe mushonga unorwisa mabhakitiriya, clavulanic acid.
Chidzidzo chakanzi "Antibiotic Therapy in Acute Exacerbations of COPD: Patient Migumisiro yeAmoxicillin uye Amoxicillin / Clavulanic Acid-Data kubva ku43,636 Outpatients" yakabudiswa mu Journal of Respiratory Research.
Kuwedzera kwakanyanya kweCOPD chiitiko umo zviratidzo zvemurwere zvinongoerekana zvawedzera. Sezvo kuwedzera uku kunowanzoenderana nehutachiona hwehutachiona, kurapwa nemishonga inorwisa mabhakitiriya (mishonga inouraya utachiona) chikamu chehutano hwekutarisira.
MuDenmark, kune maviri anowanzoshandiswa mishonga inorwisa mabhakitiriya inogona kushandiswa kurapa kuwedzera kwakadaro. Imwe ndeye 750 mg amoxicillin katatu pazuva, uye imwe yacho 500 mg amoxicillin pamwe ne125 mg clavulanic acid, zvakare katatu pazuva.
Amoxicillin ne clavulanic acid ese ari maviri beta-lactam, ari maantibioti anoshanda nekukanganisa kugadzirwa kwemadziro emasero ebhakitiriya, nekudaro achiuraya mabhakitiriya.
Nheyo yekutanga yekubatanidza maantibioti maviri aya ndeyekuti clavulanic acid inoshanda kurwisa mamwe marudzi akasiyana ebhakitiriya. Zvakadaro, kurapwa neamoxicillin chete kunoreva kuti mushonga mumwe chete unorwisa mabhakitiriya unogona kupihwa pamwero wepamusoro, unogona kupedzisira wauraya utachiona zvakanyanya.
Iye zvino, boka revatsvakurudzi veDanish rakaenzanisa zvakananga migumisiro yezvirongwa zviviri izvi zvekurapa kwekuwedzera kweCOPD.
Vatsvakurudzi vakashandisa data kubva kuDanish COPD registry, yakasanganiswa nedata kubva kune mamwe maregistries enyika, kuona varwere ve43,639 vane mamiriro ezvinhu akaipisisa avo vakagamuchira imwe yesarudzo mbiri dzakaongororwa. Kunyanya, vanhu 12,915 vakatora amoxicillin voga uye vanhu makumi matatu nemazana manomwe nenomwe vakatora mishonga yakasanganiswa. Zvakakosha kuziva kuti hapana wevarwere vakaongororwa akaiswa muchipatara nekuda kweCOPD kuwedzera, izvo zvinoratidza kuti kurwiswa kwacho kwakanga kusina kuipa.
Kuenzaniswa nemusanganiswa weamoxicillin uye clavulanic acid, kurapwa neamoxicillin chete kunogona kuderedza njodzi yekuiswa muchipatara zvine chekuita nemabayo kana kufa ne40% mushure memazuva makumi matatu. Amoxicillin chete inobatanidzwawo nekuderedzwa kwe10% munjodzi yekusarwara nemabayo muchipatara kana kufa uye kuderedzwa kwe20% mungozi yezvese-zvinokonzera kuchipatara kana kufa.
Pamatanho ese aya, mutsauko pakati pekurapa kuviri wakakosha. Ongororo yenhamba yekuwedzera inowanzowana mhinduro dzinoenderana.
Vatsvakurudzi vakanyora kuti: "Takaona kuti kana tichienzanisa neAMC [amoxicillin plus clavulanic acid], varwere veAECOPD [COPD exacerbation] vanorapwa neAMX [amoxicillin chete] vari panjodzi yekupinzwa muchipatara kana kufa nemabayo mukati memazuva makumi matatu Zvishoma."
Chikwata chinofungidzira kuti chimwe chikonzero chingangoite chemhedzisiro iyi musiyano wemuyero pakati pemishonga miviri inorwisa mabhakitiriya.
"Kana ikanwiwa pamwero mumwe chete, AMC [musanganiswa] haigone kuve yakaderera pane AMX [amoxicillin chete]," vakanyora kudaro.
Pakazere, ongororo iyi "inotsigira kushandiswa kweAMX seyakasarudzika mishonga inorwisa mabhakitiriya kune varwere vekunze vane AECOPD," vaongorori vakapedzisa nekuti "kuwedzera kwe clavulanic acid kuamoxicillin hakuna chekuita nemhedzisiro iri nani."
Sekureva kwevatsvagiri, iyo yakanyanya kuganhurirwa yechidzidzo injodzi yekuvhiringidzika nekuda kwezviratidzo-nemamwe mazwi, vanhu vanenge vatove muhurombo vanogona kunge vaine mukana wekugamuchira kurapwa kwakasanganiswa. Kunyange zvazvo vatsvakurudzi 'nhamba yekuongorora ichiedza kutsanangura chinhu ichi, zvichiri kuitika kuti kusiyana kwekutanga kwekurapa kwakatsanangura zvimwe zvemigumisiro.
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