Kwemakumi maviri emakore, albendazole yakapihwa kune chirongwa chikuru chekurapa lymphatic filariasis. Ongororo yakagadziridzwa yeCochrane yakaongorora kushanda kwe albendazole mu lymphatic filariasis.
Lymphatic filariasis chirwere chinotakurwa neumhutu chinowanikwa munzvimbo dzinopisa uye dzinopisa dzinokonzerwa nehutachiona hwefilariasis. Mushure mekutapukirwa, mhunga inokura kuva vanhu vakuru uye inobatana kuita microfilariae (mf). MF inotorwa neumhutu pavanenge vachidya ropa, uye utachiona hunogona kutapurirwa kune mumwe munhu.
Utachiona hunogona kuonekwa kuburikidza nekuongorora kutenderera kweMF (microfilaraemia) kana maantigen eparasite (antigenemia) kana nekuonekwa kwehonye mhenyu kuburikidza neultrasound.
Sangano reWorld Health Organisation (WHO) rinokurudzira kuti vanhu vakawanda varapwe pagore kweanenge makore mashanu. Nheyo yekurapa kusanganiswa kwemishonga miviri: albendazole uye microfilaricidal (antimalarial) drug diethylcarbamazine (DEC) kana ivermectin.
Albendazole semiannually inokurudzirwa munzvimbo dzine loiasis, uye DEC kana ivermectin haifaniri kushandiswa nekuda kwengozi yemigumisiro yakakomba.
Zvose ivermectin uye DEK zvakabvisa mf zvirwere nekukurumidza uye zvinogona kumisa kudzoka kwavo. Nekudaro, kugadzirwa kwemf kuchatangazve nekuda kwekuratidzwa kushoma muvakuru. Albendazole yaifungidzirwa kuti irapwe lymphatic filariasis nokuti chidzidzo chakashuma kuti madosi makuru akaitwa kwemavhiki akati wandei akaguma nemigumisiro yakakomba inoratidza kufa kwehonye dzakura.
Chirevo chisina kurongeka chekubvunzurudzwa kweWHO chakazokurudzira kuti albendazole ine kuuraya kana fungicidal mhedzisiro pavakuru. Muna 2000, GSK yakatanga kupa albendazole kuLymphatic Filariasis Treatment Programme.
Randomized clinical trials (RCTs) yakaongorora kushanda uye kuchengeteka kwe albendazole chete kana kusanganiswa ne ivermectin kana DEC. Izvi zvakateverwa nehuwandu hwekuongorora kwakarongeka kweRCTs uye data yekucherechedza, asi hazvina kujeka kana albendazole ine chero rubatsiro mu lymphatic filariasis.
Mukuona kweizvi, ongororo yeCochrane yakabudiswa muna 2005 yakagadziridzwa kuti iongorore kukanganisa kwealbendazole pahuwandu hwevanhu uye nharaunda dzine lymphatic filariasis.