Kwemakumi maviri emakore, albendazole yakapihwa kune chirongwa chikuru chekurapa lymphatic filariasis. Ongororo ichangobva kuitika yeCochrane yakaongorora kushanda kwe albendazole mukurapa lymphatic filariasis.
Lymphatic filariasis chirwere chinowanzoitika munzvimbo dzinopisa uye dzinopisa, dzinoparadzirwa neumhutu uye inokonzerwa nehutachiona hwefilariasis. Mushure mekutapukirwa, makonye anokura kuva vanhu vakuru uye anobatana kuita microfilariae (MF). Umhutu hunobva hwatora MF uchidya ropa, uye hutachiwana hunogona kupfuudzwa kune mumwe munhu.
Utachiona hunogona kuonekwa kuburikidza nekuongorora kutenderera kweMF (microfilamentemia) kana parasite antigens (antigenemia) kana nekuona honye dzevakuru dzinoshanda ne ultrasonography.
Sangano reWorld Health Organisation (WHO) rinokurudzira kuti vanhu vakawanda varapwe pagore kweanenge makore mashanu. Nheyo yekurapa kusanganiswa kwemishonga miviri: albendazole uye microfilaricidal (antifilariasis) drug diethylcarmazine (DEC) kana ivermectin.
Albendazole chete inokurudzirwa kushandiswa kwehafu-pagore munzvimbo dzine chirwere cheRoa, apo DEC kana ivermectin haifaniri kushandiswa nekuda kwengozi yemigumisiro yakakomba.
Zvose ivermectin neDEC zvakakurumidza kubvisa hutachiona hweMF uye kudzvinyirira kudzoka kwayo. Nekudaro, kugadzirwa kweMF kunotangazve nekuda kwekuratidzwa kushoma muvakuru. Albendazole yakaonekwa sekurapa lymphatic filariasis mushure mekunge ongororo yakaratidza kuti madosi makuru akapihwa kwemavhiki akati wandei akatungamira kune zvakakomba zvinokonzeresa kufa kwehonye dzakura.
Kubvunzurudzwa zvisina kurongeka kweWHO kwakazoratidza kuti albendazole ine kuuraya kana kuita sterilizing kurwisa makonye akura. Muna 2000, GlaxoSmithKline yakatanga kupa albendazole kumapurojekiti ekurapa lymphatic filariasis.
Randomized clinical trials (RCTs) yakaongorora kushanda uye kuchengeteka kwe albendazole chete kana kusanganiswa ne ivermectin kana DEC. Pashure pacho, pave nekuongororwa kwakarongeka kwezviedzo zvakagadziriswa uye data yekucherechedza, asi hazvina kujeka kana albendazole ine chero rubatsiro mu lymphatic filariasis.
Mukuona kweizvi, ongororo yeCochrane yakabudiswa muna 2005 yakagadziridzwa kuti iongorore kukanganisa kwealbendazole kune varwere uye nharaunda dzine lymphatic filariasis.
Ongororo yeCochrane iwongororo yakarongeka inovavarira kuona, kuongorora, uye kupfupisa humbowo hwese hunosangana nemaitiro akafanotemerwa kupindura mubvunzo wekutsvagisa. Ongororo yeCochrane inovandudzwa sezvo data idzva rinowanikwa.
Maitiro eCochrane anoderedza kusarura mukuita ongororo. Izvi zvinosanganisira kushandisa maturusi ekuongorora njodzi yekusarura mumiedzo yega yega uye kuongorora chokwadi (kana kunaka) kwehumbowo hwechigumisiro chimwe nechimwe.
Yakagadziridzwa Cochrane Commentary "Albendazole chete kana musanganiswa ne microfilaricidal agents mu lymphatic filariasis" yakaburitswa muna Ndira 2019 neCochrane Infectious Diseases Group uye COUNTDOWN Consortium.
Migumisiro yekufarira zvinosanganisira kutapuriranwa kwekutapurira (MF kuwanda nekuwanda), zviratidzo zvehonye dzevakuru (antigenemia kuwanda nekuwanda, uye kuvhenekwa kwehonye neultrasound), uye kuyerwa kwezviitiko zvakashata.
Vanyori vakaedza kushandisa tsvakiridzo yemagetsi kuti vawane miedzo yese yakakodzera kusvika Ndira 2018, zvisinei nemutauro kana chimiro chekuburitswa. Vanyori vaviri vakazvimiririra vakaongorora zvidzidzo zvekubatanidzwa, kuongororwa njodzi yekusarura, uye kuburitsa data reyedzo.
Ongororo iyi yaisanganisira 13 miedzo ine huwandu hwe8713 vatori vechikamu. Meta-analysis yekupararira kweparasites nemigumisiro yakaitwa kuti ione migumisiro yekurapa. Gadzirira matafura ekuongorora mhedzisiro yeparasite density, sekutaura kwakashata kunoreva kuti data haigone kuunganidzwa.
Vanyori vakaona kuti albendazole chete kana kuti pamwe chete ne microfilaricides yakanga isina zvishoma zvisingabatsiri pahuwandu hweMF pakati pemavhiki maviri nemwedzi ye12 mushure mekurapa (uchapupu hwepamusoro).
Havana kuziva kana paive nemhedzisiro yemf density pamwedzi 1-6 (uchapupu hwakaderera kwazvo) kana pamwedzi ye12 (uchapupu hwakaderera kwazvo).
Albendazole chete kana kuti pamwe chete ne microfilaricides yakanga isina zvishoma zvisingabatsiri pakupararira kweantigenemia pamusoro pemwedzi 6-12 (uchapupu hwepamusoro).
Vanyori havana kuziva kana pane mhedzisiro yeantigen density pakati pe6 uye 12 mwedzi yezera (yakanyanya kuderera-uchapupu). Albendazole yakawedzerwa kune microfilaricides zvichida yakanga iine zvishoma zvisingabatsiri pakupararira kwehonye dzevanhu vakuru dzakaonekwa ne ultrasound pamwedzi we12 (uchapupu hwakaderera).
Kana yakashandiswa yoga kana pamwe chete, albendazole yakanga isina zvishoma zvingaita pahuwandu hwevanhu vanotaura zviitiko zvakashata (uchapupu hwepamusoro).
Ongororo yakawana uchapupu hwakakwana hwokuti albendazole, yoga kana kuti pamwe chete ne microfilaricides, ine zvishoma kana kuti hazvina simba pakupedza zvachose microfilariae kana vanhu vakuru helminths mukati memwedzi ye12 yekurapa.
Zvichipa kuti mushonga uyu chikamu chemitemo yakawanda, uye kuti World Health Organization ikozvino inokurudzirawo chirongwa chemishonga mitatu, hazvigoneki kuti vatsvakurudzi vacharamba vachiongorora albendazole pamwe chete neDEC kana ivermectin.
Nekudaro, munzvimbo dzine hutachiona hweRoa, albendazole chete inokurudzirwa. Naizvozvo, kunzwisisa kana mushonga unoshanda munharaunda idzi inoramba iri chinhu chepamusoro chekutsvaga.
Zvipembenene zvakakura zvefilariatic zvine masheji ekushandisa kwenguva pfupi zvinogona kuve nemhedzisiro yakakura pamapurogiramu ekubvisa filariasis. Imwe yemishonga iyi parizvino iri mukugadzirwa kwepamberi uye yakabudiswa mune ichangoburwa BugBitten blog.
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