Vitamin C, inozivikanwawo se ascorbic acid, chinhu chakakosha chinonyungudika mumvura. Vanhu uye dzimwe mhuka (senge primates, nguruve) zvinoenderana nevhitamini C mukupihwa kwekudya kwezvibereko nemiriwo (mhiripiri tsvuku, orenji, sitirobheri, broccoli, mango, ndimu). Basa rinogona kuita revhitamini C mukudzivirira nekuvandudza hutachiona rave kuzivikanwa munharaunda yekurapa.
Ascorbic asidhi yakakosha kune immune system. Iine zvakakosha anti-inflammatory, immunomodulatory, antioxidant, anti-thrombosis uye anti-viral properties.
Vitamin C inoita kunge inokwanisa kudzora mhinduro yemuenzi kune yakanyanya acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus ndiyo inokonzeresa ye2019 coronavirus chirwere (COVID-19) denda, kunyanya Iri munguva yakaoma. Mune chirevo chazvino chakaburitswa muPreprints*, Patrick Holford et al. Yakagadziriswa basa revhitamini C senzira yekubatsira yekurapa zvirwere zvekufema, sepsis uye COVID-19.
Chinyorwa ichi chinokurukura chingangoita basa revhitamini C mukudzivirira iyo yakakosha nhanho yeCCIDID-19, acute kufema kutapukira uye zvimwe zvirwere zvekuzvimba. Vitamin C yekuwedzera inotarisirwa kuve yekudzivirira kana yekurapa mumiriri weCCIDID-19-kugadzirisa kushomeka kunokonzerwa nechirwere, kuderedza oxidative kusagadzikana, kusimudzira kugadzirwa kwe interferon uye kutsigira anti-kuzvimba mhedzisiro yeglucocorticoids.
Kuti uchengetedze mazinga eplasma akajairwa muvakuru pa50 µmol/l, muyero wevhitamini C kuvarume i90 mg/d uye kuvakadzi 80 mg/d. Izvi zvakakwana kudzivirira scurvy (chirwere chinokonzerwa nekushayikwa kwevhitamini C). Nekudaro, iyi nhanho haina kukwana kudzivirira kuratidzwa kwehutachiona uye kushushikana kwemuviri.
Nokudaro, Swiss Nutrition Society inokurudzira kuwedzera munhu mumwe nomumwe ane 200 mg yevhitamini C-kuzadza gomba rekudya kwehuwandu hwevanhu, kunyanya vakuru 65 makore uye kupfuura. Ichi chekuwedzera chakagadzirirwa kusimbisa immune system. "
Pasi pemamiriro ekushushikana kwemuviri, serum yevhitamini C mazinga anodonha nekukurumidza. Iyo serum vhitamini C yemukati yevarwere vari muchipatara ndeye ≤11µmol/l, uye vazhinji vavo vanotambura neacute kufema kutapukira, sepsis kana yakanyanya COVID-19.
Zvidzidzo zvakasiyana-siyana kubva pasirese zvakaratidza kuti yakaderera vhitamini C mazinga akajairika muvarwere vanorwara zvakanyanya muchipatara vane hutachiona hwekufema, pneumonia, sepsis uye COVID-19-tsananguro inogona kunge iri kuwedzera kushandiswa kwemetabolism.
Iyo meta-ongororo yakaratidza zvinotevera zvinocherechedzwa: 1) Vitamin C yekuwedzera inogona kuderedza zvakanyanya njodzi yemabayo, 2) Kuferefetwa mushure mekufa kubva kuCOVID-19 kwakaratidza pneumonia yechipiri, uye 3) kushomeka kweVitamin C kwakaverengera huwandu hwevanhu vane mabayo 62%.
Vitamin C ine yakakosha homeostatic mhedzisiro se antioxidant. Iyo inozivikanwa kuve ine zvakananga hutachiona hwekuuraya chiitiko uye inogona kuwedzera kugadzirwa kwe interferon. Iine maitiro ekuita mune ese ari maviri ekuzvarwa uye anogadzirisa immune system. Vitamin C inoderedza reactive oxygen marudzi (ROS) nekuputika nekuderedza kushandiswa kweNF-κB.
SARS-CoV-2 pasi-inogadzirisa kutaura kwerudzi rwekutanga interferon (mugadziri mukuru wekudzivirira antiviral), nepo ascorbic acid kumusoro-inoronga aya akakosha ekudzivirira mapuroteni.
Iyo yakakosha chikamu cheCCIDID-19 (kazhinji chikamu chinouraya) chinoitika panguva yekuwedzeredza kweanoshanda pro-kuzvimba cytokines uye chemokines. Izvi zvakaita kuti pave nekukundikana kwenhengo dzakawanda. Izvo zvine hukama nekufamba uye kuunganidzwa kweneutrophils mumapapu interstitium uye bronchoalveolar cavity, iyo yekupedzisira ichiva chinhu chakakosha cheARDS (Acute Respiratory Distress Syndrome).
Kuwanda kweascorbic acid muadrenal glands uye pituitary gland yakapetwa katatu kusvika kune gumi kupfuura mune imwe nhengo ipi zvayo. Pasi pe physiological stress (ACTH stimulation) mamiriro ezvinhu anosanganisira hutachiona hwehutachiona, vitamini C inosunungurwa kubva kune adrenal cortex, zvichiita kuti mazinga eplasma awedzere kashanu.
Vitamin C inogona kuwedzera kugadzirwa kwecortisol, uye kuwedzera anti-kuzvimba uye endothelial cell inodzivirira mhedzisiro yeglucocorticoids. Exogenous glucocorticoid steroids ndiyo chete mishonga yakaratidza kurapa COVID-19. Vitamin C ihomoni yakawanda inokurudzira, iyo inoita basa rakakosha mukuyananisa adrenal cortex kusagadzikana mhinduro (kunyanya sepsis) uye kuchengetedza endothelium kubva mukukuvadzwa kweiyo oxidative.
Kufunga nezve mhedzisiro yevhitamini C padzihwa-kuderedza nguva, kuomarara uye kuwanda kwekutonhora-kutora vhitamini C kunogona kuderedza shanduko kubva kuhutachiona hunyoro kuenda kunguva yakaoma yeCOVID-19.
Zvakaonekwa kuti vhitamini C yekuwedzera inogona kupfupisa hurefu hwekugara muICU, kupfupisa nguva yekufema kwevarwere vanorwara zvakanyanya neCCIDID-19, uye kuderedza huwandu hwekufa kwevarwere ve sepsis vanoda kurapwa nevasopressors.
Tichifunga nezvemamiriro akasiyana-siyana emararamiro, matombo etsvo uye kukanganisa kwerenal panguva yehuwandu hwepamusoro, vanyori vakakurukura nezvekuchengetedzwa kwemuromo uye intravenous kutungamirirwa kwevhitamini C. Yakachengeteka kwenguva pfupi yakakwirira ye 2-8 g / zuva inogona kukurudzirwa. ngwarira kudzivirira madosi akakwira kune vanhu vane nhoroondo yematombo eitsvo kana chirwere cheitsvo). Nemhaka yokuti inonyunguduka mumvura, inogona kubudiswa mukati memaawa mashomanana, saka chiyero chemuyero chakakosha kuchengetedza huwandu hweropa hwakakwana panguva yehutachiona hunoshanda.
Sezvatinoziva tese, vhitamini C inogona kudzivirira kutapukirwa nekuvandudza maitiro ekudzivirira. Kunyanya tichitaura nezvedanho rakakomba reCCIDID-19, vhitamini C inoita basa rakakosha. Iyo pasi-inogadzirisa dutu re cytokine, inodzivirira endothelium kubva mukukuvadzwa kweiyo oxidative, inoita basa rakakosha mukugadzirisa matishu, uye inovandudza maitiro ezvirwere zvemuviri kune hutachiona.
Munyori anokurudzira kuti mavhitamini C ekuwedzera anofanirwa kuwedzerwa zuva rega rega kukurudzira mapoka ane njodzi yakanyanya nekufa kweCCIDID-19 uye kushomeka kwevhitamini C. Vanofanira kugara vachiona kuti vhitamini C yakakwana uye kuwedzera muyero kana hutachiona hwatapukirwa, kusvika 6-8 g / zuva. Nhamba dzinoverengeka dzedoro-inotsamira vhitamini C cohort zvidzidzo zviri kuenderera pasirese kuratidza basa rayo mukubvisa COVID-19 uye kunzwisisa zviri nani basa rayo seyaigona kurapa.
Preprints ichaburitsa mishumo yekutanga yesainzi iyo isina kuongororwa nevezera, uye nekudaro haifanirwe kutorwa seyakaperera, inotungamira kiriniki maitiro / hutano-hune chekuita nemaitiro kana kutariswa ruzivo rwechokwadi.
Tags: acute kufema kunetseka syndrome, anti-inflammatory, antioxidant, ascorbic acid, ropa, broccoli, chemokine, coronavirus, coronavirus chirwere COVID-19, corticosteroid, cortisol, cytokine, cytokine, diarrhea, frequency, Glucocorticoids, mahormone, immune reaction, immune system system, kuzvimba, interstitial, itsvo, chirwere cheitsvo, kutadza kweitsvo, kufa, kudya kunovaka muviri, oxidative kusagadzikana, denda, mabayo, kufema, SARS-CoV-2, scurvy , Sepsis, yakanyanya acute kufema chirwere, yakanyanya acute kufema syndrome, sitirobheni, kushushikana, chirwere, miriwo, hutachiona, vhitamini C.
Ramya ane PhD. Pune National Chemical Laboratory (CSIR-NCL) yakagamuchira PhD muBiotechnology. Basa rake rinosanganisira kushanda nanoparticles ane akasiyana mamorekuru ekufarira biological, kudzidza maitiro masisitimu uye kuvaka anobatsira maapplication.
Dwivedi, Ramya. (2020, Gumiguru 23). Vitamin C uye COVID-19: Wongororo. News medical. Yakadzorerwa kubva https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx musi waNovember 12, 2020.
Dwivedi, Ramya. "Vitamin C uye COVID-19: Ongororo." News medical. Mbudzi 12, 2020. .
Dwivedi, Ramya. "Vitamin C uye COVID-19: Ongororo." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Yakasvika munaNovember 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C uye COVID-19: Ongororo." Nhau-Medical, yakabhurwa munaNovember 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Mubvunzurudzo iyi, Muzvinafundo Paul Tesar naKevin Allan vakaburitsa nhau kumapepanhau ezvehutano enhau nezvekudzikira kweokisijeni kukuvadza uropi.
Mubvunzurudzo iyi, Dr. Jiang Yigang vakakurukura ACROBiosystems nekuedza kwayo mukurwisa COVID-19 nekutsvaga mishonga yekudzivirira.
Mubvunzurudzo iyi, News-Medical yakakurukura nezvekuvandudzwa uye kuratidzwa kwemonoclonal antibodies naDavid Apiyo, maneja mukuru wezvikumbiro kuSartorius AG.
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