Cimetidine mushonga unovhara kugadzirwa kweasidhi nemasero anogadzira acid mudumbu uye anogona kupihwa nemuromo, IM kana IV.

Cimetidine inoshandiswa ku:

• zorodzachirungurirayakabatana neacid indigestionuye mudumbu kuvava
• kudzivirira chirungurira chinounzwa nekudya kana kunwa zvimwe zvekudya uyezvinwiwa

Ndeyekirasi yezvinodhakainonzi H2 (histamine-2) blockers iyo inosanganisiraworanitidine(Zantac),nizatidine(Axid), uyefamotidine(Pepcid) Histamine ikemikari inongoitika-inoitika inokurudzira masero mudumbu (parietal cells) kuti abudise asidi. H2-blockers inhibisa chiito che histamine pamasero, nokudaro kuderedza kugadzirwa kweasidhi nemudumbu.

Sezvo kuwandisa mudumbu acid kunogona kukuvadza iyoesophagus, dumbu, uye duodenum ne reflux uye zvinotungamira mukuzvimba uye maronda, kuderedza mudumbu asidhi inodzivirira uye inobvumira acid-induced kuzvimba uye maronda apore. Cimetidine yakabvumidzwa neFDA muna 1977.