Labaatan sano, albendazole waxaa lagu deeqay barnaamij baaxad leh oo loogu talagalay daawaynta lymfatic filariasis. Dib u eegis dhowaan Cochrane ah ayaa baadhay waxtarka albendazole ee daaweynta filariasis lymphatic.
Lymphatic filariasis waa cudur ku badan gobolada kulaylaha iyo kulaylaha hoose, waxaa gudbiya kaneecada oo ay keento caabuq filaariasis dulin ah. Infekshanka ka dib, dirxiyadu waxay u koraan qaangaar iyo lammaane si ay u sameeyaan microfilariae (MF). Kaneecadu waxay markaa soo qaadaa MF iyadoo quudinaysa dhiigga, infekshankuna wuxuu u gudbin karaa qof kale.
Caabuqa waxaa lagu ogaan karaa iyadoo la baaro wareegga wareegga MF (microfilamentemia) ama antigens parasite (antigenemia) ama iyada oo la ogaado gooryaanka qaangaarka ah ee suurtagalka ah ee ultrasonography.
Ururka Caafimaadka Adduunka (WHO) waxa uu ku talinayaa in dadka oo dhan lagu daweeyo ugu yaraan shan sano sannadkii. Saldhigga daawaynta waa isku-darka laba daawo: albendazole iyo microfilaricidal (antifilariasis) daroogada diethylcarmazine (DEC) ama ivermectin.
Albendazole oo keliya ayaa lagula talinayaa in la isticmaalo nus-sannadlaha ah meelaha uu cudurka Roa ka jiro, halkaasoo DEC ama ivermectin aan la isticmaalin khatarta waxyeellooyin halis ah awgeed.
Labada ivermectin iyo DEC labaduba waxay si degdeg ah u nadiifiyeen caabuqa MF waxayna xakameeyeen soo noqoshada. Si kastaba ha ahaatee, wax soo saarka MF ayaa dib u bilaaban doona sababtoo ah soo-gaadhista xaddidan ee dadka waaweyn. Albendazole waxaa loo tixgeliyey daawaynta filariasis lymphatic ka dib markii cilmi baaris ay muujisay in qiyaaso badan oo la siiyay dhowr toddobaad ay keentay waxyeelo halis ah oo soo jeedinaysa dhimashada gooryaanka qaangaarka ah.
La talinta aan rasmiga ahayn ee WHO ayaa ka dib muujisay in albendazole uu leeyahay fal dil ah ama nadiifin ah oo ka dhan ah Gooryaanka dadka waaweyn. Sannadkii 2000, GlaxoSmithKline wuxuu bilaabay ku-deeqidda albendazole mashaariicda lagu daweynayo filariasis lymphatic.
Tijaabooyin caafimaad oo la kala soocay (RCTs) ayaa baadhay waxtarka iyo badbaadada albendazole oo keliya ama marka lagu daro ivermectin ama DEC. Ka dib, waxaa jiray dhowr dib-u-eegis nidaamsan oo tijaaboyin la kantaroolay oo la kala soocay iyo xogta indho-indheynta, laakiin ma cadda in albendazole uu wax faa'iido ah u leeyahay filariasis lymphatic.
Marka la eego tan, dib u eegista Cochrane ee la daabacay 2005 ayaa la cusbooneysiiyay si loo qiimeeyo saameynta albendazole ee bukaannada iyo bulshooyinka qaba filariasis lymphatic.
Dib u eegista Cochrane waa dib u eegis habaysan oo ujeedadeedu tahay in la aqoonsado, la qiimeeyo, oo la soo koobo dhammaan caddaymaha la taaban karo ee buuxiya shuruudaha horay loo go'aamiyay si looga jawaabo su'aasha cilmi-baarista. Dib u eegista Cochrane waa la cusboonaysiiyay marka xog cusub la helo.
Habka Cochrane wuxuu yareeyaa eexda habka dib u eegista. Tan waxaa ka mid ah adeegsiga aaladaha lagu qiimeeyo khatarta eexda ee tijaabooyinka shaqsiyeed iyo qiimeynta hubaal (ama tayada) caddaynta natiijo kasta.
Faallaynta Cochrane ee la cusboonaysiiyay "Albendazole kaligii ama ay weheliso wakiilada microfilaricidal ee lymphatic filariasis" ayaa la daabacay Janaayo 2019 Kooxda Cudurada Infekshinka ee Cochrane iyo Ururka COUNTDOWN Consortium.
Natiijooyinka xiisaha waxaa ka mid ah suurtagalnimada gudbinta (baahnaanta MF iyo cufnaanta), calaamadaha caabuqa gooryaanka qaangaarka ah (baahnaanta antigenemia iyo cufnaanta, iyo ogaanshaha ultrasound ee gooryaanka dadka waaweyn), iyo cabbirada dhacdooyinka xun.
Qorayaashu waxay isku dayeen inay adeegsadaan raadinta elektarooniga ah si ay u helaan dhammaan tijaabooyinka khuseeya ilaa Janaayo 2018, iyadoon loo eegin luqadda ama heerka daabacaada. Laba qoraa ayaa si madaxbanaan u qiimeeyay daraasadaha lagu daro, la qiimeeyay khatarta eexda, iyo xogta tijaabada ah ee la soo saaray.
Dib u eegista waxaa ku jiray 13 tijaabo oo wadartoodu tahay 8713 ka qaybgalayaasha. Falanqaynta maadada ah ee baahsanaanta dulinnada iyo waxyeellooyinka ayaa la sameeyay si loo cabbiro saameynta daaweynta. Diyaarso jadwal si aad u falanqeyso natiijooyinka cufnaanta dulinka, maadaama warbixinta liidata ay ka dhigan tahay in xogta aan la isku dari karin.
Qorayaashu waxay ogaadeen in albendazole kaligiis ama isku-darka microfilaricides aysan wax saameyn ah ku yeelan faafitaanka MF inta u dhaxaysa laba toddobaad iyo 12 bilood ka dib daaweynta (caddayn tayo sare leh).
Ma ay ogayn in ay jirto saamayn cufnaanta mf ee 1-6 bilood (caddayn tayadeedu aad u hoosayso) ama 12 bilood (caddayn tayadeedu aad u hoosayso).
Albendazole kaligiis ama marka lagu daro microfilaricides wax yar oo saameyn ah kuma yeelan faafitaanka antigenemia ee bilaha 6-12 (caddayn tayo sare leh).
Qorayaashu ma ogaanin haddii ay jirto saameyn ku leh cufnaanta antigen inta u dhaxaysa 6 iyo 12 bilood da'da (caddayn tayadeedu aad u hooseyso). Albendazole oo lagu daray microfilaricides waxay u badan tahay inay wax yar ama wax saameyn ah ku yeelan faafitaanka gooryaanka qaangaarka ah ee lagu ogaado ultrasound-ka bilaha 12 (caddayn hubaal hoose).
Marka la isticmaalo kaligiis ama la isku daro, albendazole wax saameyn ah kuma yeelan tirada dadka soo tebiyay dhacdooyinka xun (caddayn tayo sare leh).
Dib-u-eegiddu waxay heshay caddayn ku filan in albendazole, kaligiis ama lagu daro microfilaricides, ay wax yar ama wax saameyn ah ku yeelanayso ciribtirka buuxa ee microfilariae ama helminths qaangaarka 12 bilood gudahooda ee daaweynta.
Marka la eego in dawadani ay qayb ka tahay siyaasadda guud, iyo in Ururka Caafimaadka Adduunka uu hadda sidoo kale kugula taliyo habka saddexda dawada ah, uma badna in cilmi-baarayaashu ay sii wadi doonaan inay qiimeeyaan albendazole oo ay weheliyaan DEC ama ivermectin.
Si kastaba ha ahaatee, meelaha ay ku badan tahay Roa, kaliya albendazole ayaa lagula talinayaa. Sidaa darteed, fahamka in dawadu ka shaqeyso bulshooyinkan ayaa weli ah mudnaanta cilmi baarista.
Cayayaanka fiilariga weyn ee leh jadwal codsi oo gaaban ayaa saameyn weyn ku yeelan kara barnaamijyada ciribtirka filariasis. Mid ka mid ah dawooyinkan ayaa hadda ku jira horumar degdeg ah waxaana lagu daabacay barta BugBitten ee dhowaan.
Markaad sii wadato isticmaalka boggan, waxaad ogolaatay Shuruudaha Isticmaalka, Tilmaamaha Bulshada, Bayaanka Qarsoonnimada iyo Siyaasadda Kukiyada.