Coccidiosis bakayle waa cudur meel walba ka dhaca oo uu keeno mid ama in ka badan oo ka mid ah 16 nooc oo apicomplexan genus ah.Eimeria stiedae.^1-4Calaamadaha caafimaad ee guud ee cudurka waxaa lagu gartaa caajisnimo, cunto cunid oo yaraada, shuban ama calool-istaag, beerka oo kordha, ascites, icterus, calool xanuun, iyo dhimasho.³Coccidiosis ee bakaylaha waa laga hortagi karaa oo lagu daweyn karaa iyadoo la isticmaalayo daroogo.^1,3,5,6Toltrazuril (Tol), 1-[3-methyl-4- (4-trifluoromethylsulfanyl-phenoxy) -phenyl] -3-methyl-1,3,5-triazin-2,4,6-trioneJaantuska 1), waa iskudhis triazinetrione simmetrical ah oo si weyn loogu isticmaalo ka hortagga iyo la dagaallanka coccidiosis.^7-10Si kastaba ha ahaatee, milanka aqueous liidata awgeed, Tol way adagtahay in la nuugo mareenka caloosha iyo mindhicirka (GI). Saamaynta caafimaad ee Tol waa la dhimay sababtoo ah waxay ku milmi kartaa mareenka GI.

Jaantuska 1 Qaabdhismeedka kiimikada ee toltrazuril.

Liidata biyaha tol ee liidata waxa lagaga adkaaday farsamooyinka qaar, sida kala firdhinta adag, awooda ultrafine, iyo nanoemulsion.^11-13Sida farsamooyinka hadda ugu waxtarka badan ee kordhinta milanka, daadinta adag ee Tol waxay kordhisay milanka Tol ilaa 2,000 jeer.¹¹taas oo tilmaamaysa in milmaynteeda ay weli u baahan tahay in si weyn kor loogu qaado iyada oo loo marayo farsamooyin kale. Intaa waxaa dheer, kala firdhinta adag iyo nanoemulsion waa kuwo aan degganayn oo aan ku habboonayn in la kaydiyo, halka tamarta ultrafine ay u baahan tahay qalab casri ah si loo soo saaro.

β-cyclodextrin (β-CD) waa adeegsi baahsan sababtoo ah cabbirkeeda godka gaarka ah, hufnaanta isku-dhafka daroogada, iyo kor u qaadista xasilloonida daroogada, milanka, iyo noolaha.^14,15Xaaladeeda sharciyeed, β-CD waxay ku taxan tahay ilo farmacopoeia badan, oo ay ku jiraan US Pharmacopoeia/Formulary National, Pharmacopoeia Yurub, iyo Jabbaan Codex Pharmaceutical.^16,17Hydroxypropyl-β-CD (HP-β-CD) waa hidroxyalkyl β-CD derivative kaas oo si weyn loogu daraaseeyay isku-darka daroogada sababtoo ah awoodda ka mid noqoshada iyo milanka sare ee biyaha.^18-21Daraasadaha sunta sunta ah ayaa ka warbixiyay badbaadada HP-β-CD ee marinnada xididada iyo afka ee jirka bini'aadamka,²²iyo HP-β-CD ayaa loo isticmaalay qaab-dhismeedka kiliinikada si looga gudbo arrimaha milanka liidata oo kor loogu qaado noolaha.²³

Daawooyinka oo dhan ma laha sifooyin kakan oo lagu sameeyo HP-β-CD. Tol waxa la ogaaday in uu hantidaas leeyahay iyada oo lagu salaynayo tiro badan oo shaqo baadhiseed ah. Si loo kordhiyo milanka iyo noolaha noolaha ee Tol iyadoo lagu darayo samaynta kakan ee HP-β-CD, toltrazuril-hydroxypropyl-β-cyclodextrin inclusion complex (Tol-HP-β-CD) ayaa lagu diyaariyay habka xal-kicinta daraasaddan, oo khafiif ah. Lakabka chromatography (TLC), Fourier transform infrared (FTIR) spectroscopy, iyo resonance magnetka nukliyeerka (NMR) spectroscopy ayaa ahaa loo shaqaaleysiiyay in lagu garto Tol-HP-β-CD la helay. Noocyada farmashiyaha ee Tol iyo Tol-HP-β-CD ee bakaylaha ka dib maamulka afka ayaa la barbardhigay vivo.