Faytamiin C, oo sidoo kale loo yaqaan ascorbic acid, waa nafaqo lagama maarmaan ah oo biyaha ku milma. Aadanaha iyo qaar ka mid ah xayawaanka kale (sida primates, doofaarro) waxay ku tiirsan yihiin fitamiin C ee sahayda nafaqada ee khudaarta iyo miraha (basbaaska cas, orange, strawberry, brokoli, cambe, liin). Doorka suurtagalka ah ee fitamiin C ee ka hortagga iyo hagaajinta caabuqyada ayaa lagu aqoonsaday bulshada caafimaadka.
Ascorbic acid waxay lagama maarmaan u tahay jawaabta difaaca jirka. Waxay leedahay anti-bararka muhiimka ah, immunomodulatory, antioxidant, anti-thrombosis iyo sifooyinka anti-viral.
Faytamiin C wuxuu u muuqdaa inuu awood u leeyahay inuu habeeyo jawaabta martida loo yahay ee xanuunka daran ee neef-mareenka coronavirus 2 (SARS-CoV-2). Coronavirus waa sababta keenta cudurka faafa ee coronavirus 2019 (COVID-19), gaar ahaan wuxuu ku jiraa xilli xasaasi ah. Faallo dhawaan lagu daabacay Preprints*, Patrick Holford et al. Waxaa la xalliyay doorka fitamiin C sida kaaliyaha daaweynta caabuqyada neef-mareenka, sepsis iyo COVID-19.
Maqaalkani waxa uu ka hadlayaa doorka suurtagalka ah ee fitamiin C ee ka hortagga marxaladda halista ah ee COVID-19, caabuqyada neef-mareenka ee degdega ah iyo cudurrada kale ee bararka. Kaabista Faytamiin C waxaa la filayaa inay u noqoto ka-hortag ama wakiil daawayn loogu talagalay COVID-19- hagaajinta cilladaha uu keeno cudurku, yaraynta walbahaarka oksaydhka, kor u qaadida wax soo saarka interferon iyo taageeridda saamaynta anti-bararka ee glucocorticoids.
Si loo ilaaliyo heerarka caadiga ah ee balaasmaha ee dadka waaweyn ee 50 µmol/l, qiyaasta fitamiin C ee ragga waa 90 mg/d iyo dumarka 80 mg/d. Tani waa ku filan si looga hortago scurvy (cudur ay keento fitamiin C la'aan). Si kastaba ha ahaatee, heerkani kuma filna inuu ka hortago soo-gaadhista fayraska iyo walbahaarka jireed.
Sidaa darteed, Ururka Nafaqada ee Swiss-ku waxay ku talinayaan in qof kasta lagu daro 200 mg oo fitamiin C ah si loo buuxiyo farqiga nafaqeynta ee dadweynaha guud, gaar ahaan dadka waaweyn ee 65 sano iyo ka weyn. Dheeraadkan waxaa loogu talagalay in lagu xoojiyo habka difaaca jirka. "
Marka lagu jiro xaaladaha diiqad nafsiyeed, heerarka fiitamiin C serum bini'aadamka ayaa si degdeg ah hoos ugu dhacaya. Waxa ku jira serum fiitamiin C ee bukaannada cusbitaalka la dhigay waa ≤11µmol/l, badidoodna waxa ay qabaan caabuq neef-mareenka oo degdeg ah, sepsis ama COVID-19 daran.
Kiisaska kala duwan ee adduunka oo dhan ayaa muujinaya in heerarka fitamiin C-ga hooseeya ay ku badan yihiin bukaannada aadka u xanuunsan ee isbitaallada ee qaba caabuqyada neef-mareenka, oof-wareen, sepsis iyo COVID-19- sharraxaadda ay u badan tahay waa isticmaalka dheef-shiid kiimikaadka oo kordhay.
Falanqaynta maadada ayaa iftiimisay indho-indhaynta soo socota: 1) Kaabista fitamiin C waxay si weyn u yarayn kartaa halista oof wareenka, 2) Baadhitaannada dhimashada ka dib dhimashada COVID-19 waxay muujiyeen oof wareenka labaad, iyo 3) yaraanta fitamiin C ayaa lagu tiriyaa wadarta dadka oof wareenka 62%.
Faytamiin C wuxuu leeyahay saameyn muhiim ah homeostatic sida antioxidant. Waxaa la og yahay in uu leeyahay dhaq-dhaqaaq dilaa ah oo toos ah oo fayras ah waxayna kordhin kartaa wax soo saarka interferon. Waxay leedahay habab wax ku ool ah oo ku jira hababka difaaca gudaha iyo la qabsiga labadaba. Faytamiin C wuxuu yareeyaa noocyada ogsijiinta falcelinta (ROS) iyo bararka isagoo yareynaya firfircoonida NF-kB.
SARS-CoV-2 waxay hoos u dhigtaa muujinta nooca 1 interferon (habka difaaca fayraska ee ugu weyn ee martida loo yahay), halka ascorbic acid ay nidaamiso borotiinnada difaaca martida ee muhiimka ah.
Marxaladda xasaasiga ah ee COVID-19 (badanaa marxaladda dilaaga ah) waxay dhacdaa inta lagu jiro soosaarka xad-dhaafka ah ee cytokines iyo kiimikooyin waxtar u leh caabuqa. Tani waxay keentay in ay kor u kacdo xubno badan oo gaboobay. Waxay la xiriirtaa hijrada iyo isu-ururinta neutrophils ee interstitium sambabada iyo daloolka bronchoalveolar, kan dambe oo ah go'aamiye fure u ah ARDS (Acute Respiratory Distress Syndrome).
Isku-duubnaanta ascorbic acid ee qanjidhada adrenal iyo qanjidhada pituitary ayaa saddex ilaa toban jeer ka sarreeya xubin kasta oo kale. Marka la eego cadaadiska jireed (kicinta ACTH) ee xaaladaha ay ku jiraan soo-gaadhista fayraska, fitamiin C ayaa laga sii daayaa kiliyaha adrenal, taasoo keenaysa in heerarka balaasmadu ay kordho shan laab.
Faytamiin C wuxuu wanaajin karaa soosaarka cortisol, wuxuuna wanaajin karaa kahortaga caabuqa iyo saamaynta ilaalinta unugyada endothelial ee glucocorticoids. steroids Glucocorticoid-ka-baxsan ayaa ah daawooyinka kaliya ee la xaqiijiyay in lagu daweeyo COVID-19. Faytamiin C waa hoormoon kiciya oo saameyn badan leh, kaas oo door muhiim ah ka ciyaara dhexdhexaadinta jawaab celinta walaaca kortex adrenal (gaar ahaan sepsis) iyo ka ilaalinta endothelium waxyeelada oksaydhka.
Iyadoo la tixgelinayo saameynta uu fitamiin C ku leeyahay hargabka-yaraynta muddada, darnaanta iyo inta jeer ee hargab-qaadashada fitamiin C waxay yareyn kartaa ka-guurka caabuqa fudud una gudbayo xilliga xasaasiga ah ee COVID-19.
Waxaa la arkay in kaabista fitamiin C ay soo gaabin karto muddada joogitaanka ICU, ay gaabin karto wakhtiga hawo-siinta bukaannada aadka u xanuunsan ee qaba COVID-19, iyo in la yareeyo heerka dhimashada bukaannada sepsis ee u baahan daaweynta vasopressors.
Iyadoo la tixgelinayo xaaladaha kala duwan ee shubanka, dhagxaanta kelyaha iyo kelyaha oo hawlgab ah inta lagu jiro qiyaaso badan, qorayaashu waxay ka wadahadleen badbaadada maamulka afka iyo xididada ee fitamiin C. Qiyaasta gaaban ee badbaadada leh ee 2-8 g / maalintii ayaa lagula talin karaa ( si taxadar leh uga fogow qiyaasta sare ee dadka leh taariikhda dhagxaan kelyaha ama cudurrada kelyaha). Sababtoo ah waa biyo-milmi kara, waxaa lagu soo saari karaa dhowr saacadood gudahood, sidaas awgeed inta jeer ee qiyaasta qiyaasta ayaa muhiim ah si loo ilaaliyo heerarka dhiigga ee ku filan inta lagu jiro caabuqa firfircoon.
Sida aan wada ognahay, fitamiin C wuxuu ka hortagi karaa caabuqa wuxuuna wanaajin karaa jawaabta difaaca. Gaar ahaan tixraacaya heerka xasaasiga ah ee COVID-19, fitamiin C ayaa door muhiim ah ka ciyaara. Waxay hoos u dhigtaa duufaanka cytokine, waxay ka ilaalisaa endothelium waxyeelada oksaydhka, waxay door muhiim ah ka ciyaartaa hagaajinta unugyada, waxayna wanaajisaa jawaabta difaaca ee caabuqa.
Qoraagu waxa uu ku talinayaa in kaabisyada fitamiin C lagu daro maalin kasta si loo dhiirigaliyo kooxaha khatarta sare leh ee leh dhimashada COVID-19 sare iyo yaraanta fitamiin C. Waa inay had iyo jeer hubiyaan in fitamiin C ku filan yahay oo ay kordhiyaan qiyaasta marka fayraska uu ku dhaco, ilaa 6-8 g/maalintii. Tiro ka mid ah daraasaadka kooxeed ee fitamiin C-ga ayaa ka socda adduunka oo dhan si loo xaqiijiyo doorkeeda dhimista COVID-19 iyo in si wanaagsan loo fahmo doorkeeda awood daweyn.
Preprints ayaa daabici doona warbixino saynis ah oo horudhac ah kuwaas oo aan dib loo eegin asxaabtooda, sidaa darteed waa in aan loo tixgalin gabo-gabo, hagaya ku dhaqanka kiliinikada/dhaqanada caafimaadka la xiriira ama loo tixgalinayo macluumaad qeexan.
Tags: xanuunka neef-mareenka ee ba'an, anti-bararka, antioxidant, ascorbic acid, dhiiga, brokoli, chemokine, coronavirus, cudurka coronavirus COVID-19, corticosteroid, cortisol, cytokine, cytokine, shuban, inta jeer, Glucocorticoids, hormoonnada, jawaab celinta difaaca, difaaca nidaamka, caabuqa, interstitial, kelyaha, xanuunada kelyaha, kelyaha shaqada, dhimashada, nafaqada, stress oksidative, faafa, pneumonia, neef-mareenka, SARS-CoV-2, scurvy, Sepsis, cudur neef-mareen oo daran, syndrome daran neef-mareenka, strawberry, stress, syndrome, khudaar, fayras, vitamin C
Ramya waxay haysataa PhD. Shaybaadhka Kiimikada Qaranka ee Pune (CSIR-NCL) wuxuu ku qaatay shahaadada PhD ee cilmiga bayoolajiga. Shaqadeeda waxaa ka mid ah nanoparticles shaqaynaysa oo leh unugyo kala duwan oo xiiso bayooloji ah, barashada hababka falcelinta iyo dhisidda codsiyada waxtarka leh.
Dwivedi, Ramya. (2020, Oktoobar 23). Vitamin C iyo COVID-19: dib u eegis. Wararka caafimaadka. Laga soo celiyay https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx November 12, 2020.
Dwivedi, Ramya. "Vitamin C iyo COVID-19: Dib u eegis." Wararka caafimaadka. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C iyo COVID-19: Dib u eegis." Wararka caafimaadka. https://www.news-medical.net/news/20201023/Vitamin-C-iyo-COVID-19-A-Review.aspx. (Waxa lahelay Noofambar 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C iyo COVID-19: Dib u eegis." Wararka-Caafimaadka, la daalacday Noofambar 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Wareysigan, Professor Paul Tesar iyo Kevin Allan waxay ku daabaceen wararka joornaalada caafimaadka wararka ee ku saabsan sida heerarka hoose ee ogsijiinta ay waxyeeleeyaan maskaxda.
Wareysigan, Dr. Jiang Yigang waxa ay kaga hadashay AcroBiosystems iyo dadaalkeeda ku aadan la dagaalanka COVID-19 iyo helida tallaalada
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