Ka lilemo tse mashome a mabeli, albendazole e 'nile ea fuoa lenaneo le leholo bakeng sa phekolo ea lymphatic filariasis. Tlhahlobo ea morao-rao ea Cochrane e ile ea hlahloba katleho ea albendazole kalafo ea lymphatic filariasis.
Lymphatic filariasis ke lefu le tloaelehileng libakeng tsa tropike le tsa tropike, tse fetisoang ke menoang 'me li bakoa ke tšoaetso ea parasitic filariasis. Ka mor'a tšoaetso, li-larvae li hōla ho ba tse kholo 'me li kopane ho theha microfilariae (MF). Joale monoang o nka MF ha o ntse o ja mali, 'me tšoaetso e ka fetisetsoa ho motho e mong.
Tšoaetso e ka fumanoa ka ho hlahloba MF e potolohang (microfilamentemia) kapa likokoana-hloko tsa likokoana-hloko (antigenemia) kapa ka ho lemoha liboko tsa batho ba baholo ka ultrasonography.
Mokhatlo oa Lefatše oa Bophelo (WHO) o khothaletsa phekolo ea batho ba bangata selemo le selemo bonyane lilemo tse hlano. Motheo oa phekolo ke motsoako oa lithethefatsi tse peli: albendazole le microfilaricidal (antifilariasis) lithethefatsi diethylcarmazine (DEC) kapa ivermectin.
Albendazole feela e buelloa bakeng sa tšebeliso ea halofo ea selemo libakeng tseo lefu la Roa le leng teng, moo DEC kapa ivermectin e sa lokelang ho sebelisoa ka lebaka la kotsi ea litla-morao tse tebileng.
Ka bobeli ivermectin le DEC li ile tsa hlakola ts'oaetso ea MF ka potlako mme tsa hatella ho khutla ha eona. Leha ho le joalo, tlhahiso ea MF e tla qala hape ka lebaka la ho pepeseha ho fokolang ho batho ba baholo. Albendazole e ile ea nkoa e le phekolo ea lymphatic filariasis ka mor'a hore phuputso e bonts'a hore litekanyetso tse phahameng tse fanoeng ka libeke tse 'maloa li lebisitse litla-morao tse tebileng tse bontšang lefu la liboko tse hōlileng.
Litherisano tse sa reroang tsa WHO hamorao li bonts'itse hore albendazole e na le ts'ebetso ea ho bolaea kapa ea ho bolaea liboko tse kholo. Ka 2000, GlaxoSmithKline e ile ea qala ho fana ka albendazole mererong ea ho phekola lymphatic filariasis.
Liteko tsa meriana tse sa tloaelehang (RCTs) li hlahlobile katleho le polokeho ea albendazole feela kapa hammoho le ivermectin kapa DEC. Ka mor'a moo, ho bile le litlhahlobo tse 'maloa tse hlophisitsoeng tsa liteko tse laoloang ka nako e sa lekanyetsoang le boitsebiso ba ho shebella, empa ha ho hlake hore na albendazole e na le molemo ofe kapa ofe ho lymphatic filariasis.
Ka lebaka la sena, tlhahlobo ea Cochrane e hatisitsoeng ka 2005 e ntlafalitsoe ho hlahloba phello ea albendazole ho bakuli le sechaba se nang le lymphatic filariasis.
Litlhahlobo tsa Cochrane ke litlhahlobo tse hlophisitsoeng tse ikemiselitseng ho tseba, ho lekola, le ho akaretsa bopaki bohle ba bopaki bo fihlelang litekanyetso tse reriloeng esale pele ho araba potso ea lipatlisiso. Maikutlo a Cochrane a ntlafatsoa ha data e ncha e ntse e fumaneha.
Mokhoa oa Cochrane o fokotsa leeme ts'ebetsong ea tlhahlobo. Sena se kenyelletsa ho sebelisa lisebelisoa ho lekola kotsi ea leeme litekong tsa motho ka mong le ho lekola bonnete (kapa boleng) ba bopaki bakeng sa sephetho ka seng.
Tlhaloso e ntlafalitsoeng ea Cochrane "Albendazole e le 'ngoe kapa e kopantsoe le li-microfilaricidal agents in lymphatic filariasis" e phatlalalitsoe ka Pherekhong 2019 ke Cochrane Infectious Diseases Group le COUNTDOWN Consortium.
Liphello tsa thahasello li kenyelletsa bokhoni ba phetiso (ho ata le ho teteana ha MF), matšoao a tšoaetso ea liboko tsa batho ba baholo (ho ata le ho teteana ha antigenemia, le ho lemoha liboko tsa batho ba baholo ka ultrasound), le litekanyo tsa liketsahalo tse mpe.
Bangoli ba lekile ho sebelisa patlisiso ea elektroniki ho fumana liteko tsohle tse amehang ho fihlela Pherekhong 2018, ho sa tsotelehe puo kapa boemo ba phatlalatso. Bangoli ba babeli ba hlahlobile lithuto tsa boikemelo bakeng sa ho kenyeletsoa, ​​ho lekola kotsi ea leeme, le data e nkiloeng ea liteko.
Tlhahlobo e kenyelelitse liteko tsa 13 ka kakaretso ea barupeluoa ba 8713. Tlhahlobo ea meta ea ho ata ha likokoana-hloko le litla-morao e ile ea etsoa ho lekanya liphello tsa phekolo. Lokisetsa litafole ho sekaseka liphetho tsa bongata ba likokoana-hloko, kaha tlaleho e fosahetseng e bolela hore data e ke ke ea kopanngoa.
Bangoli ba fumane hore albendazole feela kapa hammoho le microfilaricides e ne e se na phello e fokolang ho ata ha MF pakeng tsa libeke tse peli le likhoeli tsa 12 ka mor'a phekolo (bopaki ba boleng bo phahameng).
Ba ne ba sa tsebe hore na ho na le phello ho mf density likhoeling tsa 1-6 (bopaki ba boleng bo tlaase haholo) kapa likhoeling tsa 12 (bopaki ba boleng bo tlaase haholo).
Albendazole e le 'ngoe kapa e kopantsoe le microfilaricides e ne e se na phello e fokolang ho ata ha antigenemia ho feta likhoeli tsa 6-12 (bopaki ba boleng bo phahameng).
Bangoli ba ne ba sa tsebe hore na ho na le phello ea matla a antigen pakeng tsa 6 le likhoeli tsa 12 (bopaki ba boleng bo tlaase haholo). Albendazole e kenyellelitsoeng ho microfilaricides mohlomong e ne e se na phello e fokolang ho ata ha liboko tse kholo tse fumanoeng ke ultrasound likhoeling tsa 12 (bopaki bo fokolang bo fokolang).
Ha e sebelisoa e le mong kapa e kopane, albendazole e ne e se na phello e fokolang palo ea batho ba tlalehang liketsahalo tse mpe (bopaki ba boleng bo phahameng).
Tlhahlobo e fumane bopaki bo lekaneng ba hore albendazole, e le 'ngoe kapa e kopantsoe le microfilaricides, e na le phello e fokolang kapa ha e na phello e feletseng ea ho felisa microfilariae kapa helminths e kholo nakong ea likhoeli tsa 12 tsa phekolo.
Kaha sethethefatsi sena ke karolo ea leano le tloaelehileng, le hore Mokhatlo oa Lefatše oa Bophelo o boetse o khothalletsa hore ho sebelisoe lithethefatsi tse tharo, ho ke ke ha etsahala hore bafuputsi ba tsoele pele ho hlahloba albendazole hammoho le DEC kapa ivermectin.
Leha ho le joalo, libakeng tse tloaelehileng bakeng sa Roa, ke albendazole feela e khothalletsoang. Ka hona, ho utloisisa hore na sethethefatsi se sebetsa lichabeng tsena e lula e le taba ea mantlha ea lipatlisiso.
Likokoana-hloko tse kholo tsa filariatic tse nang le kemiso ea nako e khutšoanyane ea kopo li ka ba le phello e kholo mananeong a ho felisa filariasis. E 'ngoe ea litlhare tsena hajoale e ntse e ntlafatsoa esale pele mme e phatlalalitsoe ho blog ea morao-rao ea BugBitten.
Ka ho tsoela pele ho sebelisa sebaka sena sa marang-rang, u lumellana le Melao ea Ts'ebeliso ea rona, Litaelo tsa Sechaba, Polelo ea Lekunutu le Leano la Cookie.