Vithamine C, eo hape e tsejoang e le ascorbic acid, ke limatlafatsi tsa bohlokoa tse qhibilihang ka metsing. Batho le liphoofolo tse ling (tse kang litšoene, likolobe) li itšetlehile ka vithamine C phepelong ea phepo ea litholoana le meroho (pepere e khubelu, lamunu, fragola, broccoli, mango, lemon). Karolo e ka bang teng ea vithamine C ho thibela le ho ntlafatsa ts'oaetso e lemohuoe sechabeng sa bongaka.
Ascorbic acid e bohlokoa bakeng sa karabelo ea 'mele ea ho itšireletsa mafung. E na le thepa ea bohlokoa ea anti-inflammatory, immunomodulatory, antioxidant, anti-thrombosis le anti-viral.
Vithamine C e bonahala e khona ho laola karabelo ea moamoheli ho lefu le matla la ho hema coronavirus 2 (SARS-CoV-2). Coronavirus ke sesosa sa seoa sa lefu la seoa sa 2019 (COVID-19), haholo-holo se nakong e mahlonoko. Ka maikutlo a morao-rao a hatisitsoeng ho Preprints *, Patrick Holford et al. E rarollotse karolo ea vithamine C e le kalafo e thusang bakeng sa ts'oaetso ea phefumoloho, sepsis le COVID-19.
Sengoliloeng sena se bua ka karolo e ka bang teng ea vithamine C ho thibela boemo bo mahlonoko ba COVID-19, mafu a hlobaetsang a phefumoloho le mafu a mang a ho ruruha. Tlatsetso ea Vithamine C e lebelletsoe ho ba moemeli oa thibelo kapa oa kalafo bakeng sa bofokoli ba ho lokisa COVID-19 bo bakoang ke lefu lena, ho fokotsa khatello ea oxidative, ho ntlafatsa tlhahiso ea interferon le ho ts'ehetsa litlamorao tse khahlanong le ho ruruha tsa glucocorticoids.
Bakeng sa ho boloka maemo a tloaelehileng a plasma ho batho ba baholo ho 50 μmol/l, tekanyetso ea vithamine C ho banna ke 90 mg/d le ho basali 80 mg/d. Sena se lekane ho thibela scurvy (lefu le bakoang ke khaello ea vithamine C). Leha ho le joalo, boemo bona ha boa lekana ho thibela tšoaetso ea kokoana-hloko le khatello ea kelello ea 'mele.
Ka hona, Mokhatlo oa Swiss Nutrition o khothalletsa ho tlatsetsa motho e mong le e mong ka 200 mg ea vithamine C-ho tlatsa lekhalo la phepo e nepahetseng ea batho ba bangata, haholo-holo batho ba baholo ba lilemo li 65 le ho feta. Tlatsetso ena e etselitsoe ho matlafatsa sesole sa 'mele. "
Tlas'a maemo a khatello ea kelello ea 'mele, maemo a serum ea vithamine C a theoha ka potlako. Likahare tsa serum ea vithamine C ea bakuli ba sepetlele ke ≤11µmol/l, 'me boholo ba bona ba tšoeroe ke tšoaetso e matla ea ho hema, sepsis kapa COVID-19 e matla.
Lithuto tse fapaneng tse tsoang lefats'eng ka bophara li bonts'a hore maemo a tlase a vithamine C a tloaelehile ho bakuli ba sepetlele ba kulang haholo ba nang le ts'oaetso ea ho hema, pneumonia, sepsis le COVID-19-tlhaloso e ka bang teng ke ho eketseha ha ts'ebeliso ea metabolic.
Tlhahlobo ea meta e totobalitse maikutlo a latelang: 1) Tlatsetso ea Vitamin C e ka fokotsa haholo kotsi ea pneumonia, 2) Liphuputso tsa kamora lefu la COVID-19 li bonts'itse pneumonia ea bobeli, mme 3) Khaello ea Vitamin C e bakile palo eohle ea batho ba nang le lefu la pneumonia. pneumonia 62%.
Vithamine C e na le phello ea bohlokoa ea homeostatic joalo ka antioxidant. E tsebahala hore e na le ts'ebetso e tobileng ea ho bolaea kokoana-hloko 'me e ka eketsa tlhahiso ea interferon. E na le mekhoa e sebetsang tsamaisong ea 'mele ea ho itšireletsa mafung le ea tlhaho. Vithamine C e fokotsa mefuta ea oksijene e sebetsang (ROS) le ho ruruha ka ho fokotsa ts'ebetso ea NF-κB.
SARS-CoV-2 e laola polelo ea mofuta oa 1 interferon (mochine o ka sehloohong oa ts'ireletso ea antiviral), athe ascorbic acid e laola liprotheine tsena tsa bohlokoa tsa ts'ireletso.
Karolo e mahlonoko ea COVID-19 (hangata e bolaeang) e etsahala nakong ea tlhahiso e fetelletseng ea li-cytokine le li-chemokine tse sebetsang hantle tsa pro-inflammatory. Sena se ile sa lebisa ho nts'etsopele ea ho hlōleha ha litho tse ngata. E amana le ho falla le ho bokellana ha li-neutrophils ka har'a lung interstitium le bronchoalveolar cavity, ea morao-rao e le sekhetho se ka sehloohong sa ARDS (Acute Respiratory Distress Syndrome).
Khatello ea asiti ea ascorbic litšoelesa tsa adrenal le pituitary e phahame ka makhetlo a mararo ho isa ho a leshome ho feta sethong sefe kapa sefe. Tlas'a khatello ea 'mele (ACTH stimulation) maemo a kenyeletsang ho pepeseha ha kokoana-hloko, vithamine C e lokolloa ho adrenal cortex, e leng se etsang hore maemo a plasma a eketsehe ka makhetlo a mahlano.
Vithamine C e ka ntlafatsa tlhahiso ea cortisol, 'me ea ntlafatsa litlamorao tsa ts'ireletso ea lisele tsa glucocorticoids. Exogenous glucocorticoid steroids ke tsona feela lithethefatsi tse netefalitsoeng ho phekola COVID-19. Vithamine C ke hormone e susumetsang lintho tse ngata, e phethang karolo ea bohlokoa ho kopanyelletsa karabelo ea khatello ea kelello ea adrenal cortex (haholo-holo sepsis) le ho sireletsa endothelium ho senyeha ha oxidative.
Ho ela hloko phello ea vithamine C mabapi le sefuba-ho fokotsa nako, matla le khafetsa ea vithamine C e nkang sefuba ho ka fokotsa phetoho ho tloha tšoaetsong e bobebe ho ea nakong e mahlonoko ea COVID-19.
Ho hlokometsoe hore tlatsetso ea vithamine C e ka khutsufatsa nako ea ho lula ICU, ea khutsufatsa nako ea moea ea bakuli ba kulang haholo ba nang le COVID-19, le ho fokotsa sekhahla sa lefu la bakuli ba sepsis ba hlokang kalafo ka li-vasopressors.
Ho nahanoa ka maemo a sa tšoaneng a letšollo, majoe a liphio le ho hlōleha ha renal nakong ea tekanyo e phahameng, bangoli ba ile ba buisana ka tšireletseho ea tsamaiso ea molomo le methapo ea vithamine C. Tekanyo e phahameng e sireletsehileng ea nako e khutšoanyane ea 2-8 g / letsatsi e ka buelloa. qoba ka hloko litekanyetso tse phahameng bakeng sa batho ba nang le histori ea majoe a liphio kapa lefu la liphio). Hobane e qhibiliha ka metsing, e ka ntšoa ka mor'a lihora tse 'maloa, kahoo makhetlo a mangata a litekanyetso a bohlokoa ho boloka maemo a lekaneng a mali nakong ea tšoaetso e sebetsang.
Joalokaha bohle re tseba, vithamine C e ka thibela tšoaetso le ho ntlafatsa karabelo ea 'mele ea ho itšireletsa mafung. Haholo-holo ha re bua ka boemo bo mahlonoko ba COVID-19, vithamine C e bapala karolo ea bohlokoa. E theola-e laola sefefo sa cytokine, e sireletsa endothelium tšenyo ea oxidative, e phetha karolo ea bohlokoa ho lokisoeng ha lisele, le ho ntlafatsa karabelo ea 'mele ea ho itšireletsa mafung ho tšoaetso.
Sengoli se khothaletsa hore li-supplement tsa vithamine C li eketsoe letsatsi le leng le le leng ho khothaletsa lihlopha tse kotsing e kholo tse nang le lefu le phahameng la COVID-19 le khaello ea vithamine C. Kamehla ba lokela ho etsa bonnete ba hore vithamine C e lekane le ho eketsa lethal dose ha kokoana-hloko e tšoaelitsoe, ho fihlela ho 6-8 g / letsatsi. Lithuto tse 'maloa tsa sehlopha sa vithamine C tse itšetlehileng ka litekanyetso li ntse li tsoela pele lefats'eng ka bophara ho netefatsa karolo ea eona ho kokobetseng COVID-19 le ho utloisisa hamolemo karolo ea eona e le monyetla oa kalafo.
Litlaleho tsa pele li tla phatlalatsa litlaleho tsa mahlale tse sa kang tsa hlahlojoa ke lithaka, ka hona, ha lia lokela ho nkuoa e le tse phetheselang, tse tataisang boikoetliso ba bongaka/boitšoaro bo amanang le bophelo bo botle kapa tlhahisoleseling e hlakileng.
Tags: acute breath distress syndrome, anti-inflammatory, antioxidant, ascorbic acid, mali, broccoli, chemokine, coronavirus, lefu la coronavirus COVID-19, corticosteroid, cortisol, cytokine, cytokine, letšollo, khafetsa, Glucocorticoids, lihomone, karabelo ea 'mele ea ho itšireletsa mafung tsamaiso, ho ruruha, interstitial, liphio, lefu la liphio, ho hloleha ha liphio, lefu, phepo e nepahetseng, khatello ea kelello ea oxidative, seoa, pneumonia, phefumoloho, SARS-CoV-2, scurvy, Sepsis, lefu le matla le matla la ho hema, lefu le matla la ho hema, fragola, khatello ea maikutlo, lefu la tsoekere, meroho, vaerase, vithamine C.
Ramya o na le PhD. Pune National Chemical Laboratory (CSIR-NCL) e amohetse PhD ea Biotechnology. Mosebetsi oa hae o kenyelletsa ho sebetsa li-nanoparticles tse nang le limolek'hule tse fapaneng tsa thahasello ea tlhaho, ho ithuta litsamaiso tsa karabelo le ho aha lits'ebetso tse sebetsang.
Dwivedi, Ramya. (2020, Mphalane 23). Vithamine C le COVID-19: Tlhahlobo. Litaba tsa bongaka. E nkiloe ho https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ka la 12 Pulungoana 2020.
Dwivedi, Ramya. "Vithamine C le COVID-19: Tlhahlobo." Litaba tsa bongaka. La 12 Pulungoana 2020. .
Dwivedi, Ramya. "Vithamine C le COVID-19: Tlhahlobo." Litaba tsa bongaka. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (E fumaneha ka la 12 Pulungoana 2020).
Dwivedi, Ramya. 2020. "Vithamine C le COVID-19: Tlhahlobo." News-Medical, e phatlalalitsoe ka la 12 Pulungoana 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Puisanong ena, Moprofesa Paul Tesar le Kevin Allan ba ile ba hatisa litaba likoranteng tsa litaba tsa bongaka mabapi le kamoo maemo a tlaase a oksijene a senyang boko kateng.
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