Uphononongo lwaseDanish lubonise ukuba kwizigulana ezinokwanda kakhulu kwesifo semiphunga esingapheliyo (COPD), i-amoxicillin iyodwa ineziphumo ezingcono kune-amoxicillin edityaniswe nesinye isithinteli-ntsholongwane, i-clavulanic acid.
Uphononongo olunesihloko esithi "Unyango lwe-Antibiotic kwi-Acute Exacerbations yeCOPD: Iziphumo zesigulane se-Amoxicillin kunye ne-Amoxicillin / i-Clavulanic Acid-Data esuka kwi-43,636 Outpatients" yapapashwa kwi-Journal yoPhando lokuPhumla.
Ukugqithiswa ngokukrakra kweCOPD sisiganeko apho iimpawu zesigulana ziba mandundu ngokukhawuleza. Ekubeni oku kukhula ngokuqhelekileyo kunxulumene nosulelo lwebhaktheriya, unyango ngamayeza okubulala iintsholongwane (iziyobisi ezibulala ibhaktheriya) yinxalenye yomgangatho wokunyamekela.
E-Denmark, kukho iirejimeni ezimbini ezisetyenziswa ngokuqhelekileyo izibulala-zintsholongwane ezinokuthi zisetyenziswe ukunyanga oko mandundu. Enye yi-750 mg ye-amoxicillin kathathu ngemini, kwaye enye yi-500 mg ye-amoxicillin kunye ne-125 mg ye-clavulanic acid, kwakhona kathathu ngemini.
I-Amoxicillin kunye ne-clavulanic acid zombini zii-beta-lactam, ngamayeza okubulala iintsholongwane asebenza ngokuphazamisana nokuveliswa kweendonga zeeseli zebhaktiriya, ngaloo ndlela zibulala iintsholongwane.
Umgaqo osisiseko wokudibanisa ezi ntsholongwane zimbini zokubulala iintsholongwane kukuba i-clavulanic acid iyasebenza ngokuchasene neendidi ezininzi zebhaktiriya. Nangona kunjalo, unyango nge-amoxicillin yodwa luthetha ukuba iyeza lokubulala iintsholongwane elinye linokunikezelwa ngedosi ephezulu, enokuthi ekugqibeleni ibulale ibhaktheriya ngokufanelekileyo.
Ngoku, iqela labaphandi baseDenmark lithelekise ngokuthe ngqo iziphumo zezi rejimeni zimbini kunyango lokwandiswa okubukhali kweCOPD.
Abaphandi basebenzise idatha evela kwi-registry yaseDenmark ye-COPD, idibaniswe nedatha evela kwezinye iirejista zelizwe, ukuchonga izigulane ze-43,639 ezineemeko ezinzima eziye zafumana enye yeendlela ezimbini ezihlalutyiweyo. Ngokukodwa, abantu abayi-12,915 bathatha i-amoxicillin yodwa kwaye abantu abangama-30,721 bathatha amayeza adibeneyo. Kuyafaneleka ukuba uqaphele ukuba akukho nasinye izigulane ezihlalutywayo esibhedlele ngenxa yokunyuka kweCOPD, ebonisa ukuba uhlaselo aluzange lube lukhulu.
Xa kuthelekiswa nokudityaniswa kwe-amoxicillin kunye ne-clavulanic acid, unyango nge-amoxicillin yodwa lunokunciphisa umngcipheko wokulaliswa esibhedlele okunxulumene nenyumoniya okanye yonke into engunobangela wokufa ngama-40% emva kweentsuku ezingama-30. I-Amoxicillin yodwa iphinda idibaniswe nokunciphisa i-10% kwingozi ye-non-pneumonia yokulaliswa esibhedlele okanye ukufa kunye nokunciphisa i-20% kwingozi yazo zonke izizathu zokulaliswa esibhedlele okanye ukufa.
Kuwo onke la manyathelo, umahluko phakathi kwala mayeza mabini ubalulekile ngokwezibalo. Uhlalutyo olongezelelweyo lwamanani luya kufumana iziphumo ezihambelanayo.
Abaphandi babhala bathi: "Sifumene ukuba xa kuthelekiswa ne-AMC [i-amoxicillin kunye ne-clavulanic acid], i-AECOPD [i-COPD exacerbation] izigulane ezinyangwa nge-AMX [i-amoxicillin yodwa] zisemngciphekweni wokulaliswa esibhedlele okanye ukusweleka ngenyumoniya phakathi kweentsuku ezingama-30 Ephantsi kakhulu."
Iqela liqikelela ukuba esinye isizathu esinokubakho sesi siphumo ngumahluko kwidosi phakathi kweerejimeni ezimbini zokubulala iintsholongwane.
"Xa isetyenziswe ngedosi enye, i-AMC [indibaniselwano] ayinakwenzeka ukuba ibe ngaphantsi kwe-AMX [i-amoxicillin yodwa]," babhala.
Ngokubanzi, uhlalutyo "luxhasa ukusetyenziswa kwe-AMX njengonyango olukhethwayo lokubulala iintsholongwane kwizigulane ezingaphandle kwe-AECOPD," abaphandi baphetha ngokuba "ukongezwa kwe-clavulanic acid kwi-amoxicillin ayinanto yakwenza neziphumo ezingcono."
Ngokutsho kwabaphandi, umda oyintloko wophononongo ngumngcipheko wokudideka ngenxa yezibonakaliso-ngamanye amagama, abantu abasele bekwimeko embi banokuthi bafumane unyango oludibeneyo. Nangona uhlalutyo lwamanani lwabaphandi luzama ukucacisa le nto, kusengenzeka ukuba umahluko wangaphambili wonyango uchaze ezinye zeziphumo.
Le webhusayithi ngokungqongqo iwebhusayithi yeendaba kunye nolwazi malunga nesi sifo. Ayiboneleli ngengcebiso yezonyango, ukuxilongwa okanye unyango. Lo mxholo awuthathi ndawo yeengcebiso zonyango, ukuxilongwa okanye unyango. Ukuba unayo nayiphi na imibuzo malunga neemeko zonyango, soloko ufuna iingcebiso zogqirha wakho okanye omnye umboneleli wezempilo oqeqeshiweyo. Musa ukungayihoyi ingcebiso yezonyango okanye ukulibazisa ukufuna iingcebiso zonyango ngenxa yento oyifundileyo kule webhusayithi.