Kwiminyaka engamashumi amabini, i-albendazole inikezelwe kwiprogram enkulu yonyango lwe-lymphatic filariasis. Uphononongo oluhlaziyiweyo lwe-Cochrane luhlolisise ukusebenza kwe-albendazole kwi-lymphatic filariasis.
I-Lymphatic filariasis sisifo esithwalwa ziingcongconi esixhaphake kwiindawo ezishushu kunye neendawo ezishushu ezibangelwa lusulelo lwe-parasitic filariasis. Emva kosulelo, imibungu ikhula ibe ngabantu abadala kwaye iqabane yenze i-microfilariae (mf). I-MF ke iqokelelwa ziingcongconi ngelixa isondla igazi, kwaye usulelo lunokudluliselwa komnye umntu.
Ukosuleleka kunokufunyaniswa ngovavanyo lokujikeleza kweMF (microfilaraemia) okanye iiantigens zeparasite (antigenemia) okanye ngokubhaqwa kweentshulube eziphilayo eziphilayo nge-ultrasound.
UMbutho wezeMpilo weHlabathi (i-WHO) ucebisa ukuba kunyangwe abantu abaninzi ngonyaka ubuncinci iminyaka emihlanu. Isiseko sonyango yindibaniselwano yamachiza amabini: i-albendazole kunye ne-microfilaricidal (antimalarial) i-diethylcarbamazine (DEC) okanye ivermectin.
I-Albendazole i-semiannually inconywa kwiindawo apho i-loiasis i-co-endemic, kunye ne-DEC okanye i-ivermectin akufanele isetyenziswe ngenxa yengozi yemiphumo emibi.
Zombini i-ivermectin kunye ne-DEK zacoca usulelo lwe-mf ngokukhawuleza kwaye zinokunqanda ukuvela kwazo kwakhona. Nangona kunjalo, imveliso ye-mf iya kuqalisa kwakhona ngenxa yokuvezwa okulinganiselweyo kubantu abadala. I-Albendazole yaqwalaselwa kunyango lwe-lymphatic filariasis kuba uphononongo luchaze ukuba iidosi eziphezulu ezilawulwa kwiiveki ezininzi zibangele iziphumo ezibi kakhulu ezibonisa ukufa kweentshulube zabantu abadala.
Ingxelo engacwangciswanga yokubonisana kwe-WHO emva koko yacebisa ukuba i-albendazole inokubulala okanye isiphumo sokungunda kubantu abadala. Kwi-2000, i-GSK yaqala ukunikela nge-albendazole kwiNkqubo yoNyango lwe-Lymphatic Filariasis.
Izilingo zeklinikhi ezingahleliwe (RCTs) ziye zavavanya ukusebenza kunye nokhuseleko lwe-albendazole yedwa okanye ngokudibanisa ne-ivermectin okanye i-DEC. Oku kuye kwalandelwa ukuphononongwa okucwangcisiweyo kwe-RCTs kunye neenkcukacha zokujonga, kodwa akucaci ukuba i-albendazole inenzuzo nayiphi na i-lymphatic filariasis.
Ngenxa yoko, ukuhlaziywa kwe-Cochrane epapashwe kwi-2005 ihlaziywe ukuvavanya impembelelo ye-albendazole kubantu kunye noluntu olune-lymphatic filariasis.