Ulawulo oludibeneyo lwe-ivermectin, i-diethylcarbamazine, kunye ne-albendazole iqinisekisa ukhuseleko lwe-pharmacotherapy

Yazisa:

Kwinkqubela phambili yamanyathelo ezempilo yoluntu, abaphandi baye baqinisekisa ukhuseleko kunye nokusebenza komxube omkhulu weziyobisi we-ivermectin, i-diethylcarbamazine (DEC) kunye ne-albendazole. Le nkqubela phambili inkulu iya kuba nefuthe kakhulu kwiinzame zehlabathi zokulwa nezifo ezahlukeneyo ezingahoywanga kwitropiki (NTDs).

imvelaphi:

Izifo zetropikhi ezingahoywanga zichaphazela abantu abangaphezu kwebhiliyoni kumazwe ahlwempuzekileyo kwaye zibeka imicelimngeni emikhulu kwimpilo yehlabathi. I-Ivermectin isetyenziswa ngokubanzi ukunyanga izifo ze-parasitic, kuquka ukungaboni komlambo, ngelixa i-DEC ijolise kwi-lymphatic filariasis. I-Albendazole iyasebenza ngokuchasene neentshulube zamathumbu. Ulawulo-ndawonye lwala machiza lunokujongana nee-NTD ezininzi ngaxeshanye, nto leyo eyenza ukuba iirejimeni zonyango zisebenze kakuhle kwaye zibeneendleko.

Ukhuseleko nokusebenza:

Uphononongo lwakutsha nje olwenziwe liqela labaphandi bamazwe ngamazwe lujolise ekuvavanyeni ukhuseleko lokuthatha la machiza mathathu kunye. Ulingo lwabandakanya ngaphezulu kwe-5,000 yabathathi-nxaxheba kumazwe amaninzi, kuquka lawo anosulelo oluhlangeneyo. Iziphumo zophononongo zibonise ukuba unyango oludityanisiweyo lunyanyezelwe kakuhle kwaye luneziphumo ezibi ezincinci. Qaphela, iziganeko kunye nobukhulu beziganeko ezimbi zifana nezo zabonwa xa ichiza ngalinye lithathwa lodwa.

Ngaphaya koko, ukusebenza kwendibaniselwano yamachiza kumlinganiselo omkhulu kuyancomeka. Abathathi-nxaxheba babonise ukunciphisa okukhulu kumthwalo we-parasite kunye nokuphucula iziphumo zeklinikhi kuzo zonke izifo eziphathwayo. Esi siphumo asibonakalisi kuphela umphumo we-synergistic wonyango oludibeneyo kodwa lubonelela ngobungqina obongezelelweyo bokwenzeka kunye nokuzinza kweenkqubo zolawulo olubanzi lwe-NTD.

Impembelelo kwimpilo yoluntu:

Ukuphunyezwa ngempumelelo kwamayeza adibeneyo kuzisa ithemba elikhulu kwimisebenzi yonyango olukhulu lwamachiza. Ngokudibanisa amayeza amathathu angundoqo, la manyathelo anokuthi alungelelanise ukusebenza kwaye anciphise iindleko kunye nobunzima bokuhamba okuhambelana nokuqhuba izicwangciso zonyango ezahlukeneyo. Ukongeza, ukwanda kokusebenza kunye neziphumo ebezingalindelekanga ezincitshisiweyo zenza le ndlela idume kakhulu, iqinisekisa ukuthotyelwa okungcono kunye neziphumo.

Iinjongo zokuphelisa ihlabathi:

Ukuhlanganiswa kwe-ivermectin, i-DEC kunye ne-albendazole ihambelana ne-World Health Organization (WHO) indlela yokuphelisa ii-NTD. Iinjongo zoPhuhliso oluZinzileyo (SDGs) zibiza ukulawula, ukupheliswa okanye ukupheliswa kwezi zifo ngo-2030. Olu nyango oludibeneyo lubonisa inyathelo elibalulekileyo ekufezekiseni ezi njongo, ngakumbi kwimimandla apho ii-NTD ezininzi zihlala khona.

ithemba:

Impumelelo yolu phononongo ivula indlela yokwandiswa kwezicwangciso zonyango ezidityanisiweyo. Abaphandi ngoku baphanda amandla okubandakanya amanye amayeza e-NTD-specific kunyango oludityanisiweyo, olufana nepraziquantel yeschistosomiasis okanye i-azithromycin yetrakoma. La manyathelo abonisa ukuzibophelela koluntu lwenzululwazi ekuqhubekekeni ukulungelelanisa nokuphuhlisa iinkqubo zolawulo lwe-NTD.

Imingeni kunye nezigqibo:

Nangona ulawulo oludibeneyo lwe-ivermectin, i-DEC, kunye ne-albendazole ibonelela ngeenzuzo ezinkulu, imingeni isekhona. Ukulungelelanisa ezi zikhetho zonyango kwiindawo ezahlukeneyo zejografi, ukuqinisekisa ukufikeleleka, kunye nokoyisa imiqobo yolungiselelo kuya kufuna inzame yentsebenziswano phakathi koorhulumente, imibutho yamazwe ngamazwe, kunye nababoneleli bezempilo. Nangona kunjalo, amandla okuphucula iziphumo zempilo yoluntu kwiibhiliyoni zabantu ayodlula le mingeni.

Ekugqibeleni, ukudibanisa okuphumelelayo kwe-ivermectin, i-DEC, kunye ne-albendazole ibonelela ngesisombululo esisebenzayo nesikhuselekileyo sonyango olukhulu lwezifo zetropiki ezingahoywayo. Le ndlela ibanzi inesithembiso esikhulu sokufikelela kwiinjongo zokupheliswa kwehlabathi kwaye iqaqambisa ukuzinikela koluntu lwenzululwazi ekujonganeni ngqo nemingeni yempilo yoluntu. Ngophando olongezelelweyo kunye namanyathelo aqhubekayo, ikamva lolawulo lwe-NTD libonakala liqaqambile kunangaphambili.