I-Streptomycin Sulfate: I-Aminoglycoside Antibiotic enamandla kwi-Modern Medicine

Kwindawo ye-antibiotics, i-Streptomycin Sulfate ivelele njenge-aminoglycoside ethembekileyo nenamandla eye yaba negalelo ekulweni nosulelo lwebhaktheriya amashumi eminyaka. Le khompawundi iguquguqukayo, kunye neendlela zayo ezizodwa zokwenza, iyaqhubeka isisiseko kunyango oluchasene nosulelo kwihlabathi jikelele.

Yintoni iStreptomycin Sulfate?

I-Streptomycin Sulfate, ephethe inombolo ye-CAS 3810-74-0, yi-antibiotic ye-aminoglycoside ephuma kwi-Streptomyces griseus, ibhaktheriya yomhlaba. Ibonakaliswe ngokukwazi kwayo ukuthintela iprotein synthesis kwiiseli zebhaktheriya, ukumisa ngokufanelekileyo ukukhula kwazo kunye nokuphindaphinda. Le antibiotic ifumaneka kumabakala ahlukeneyo, kubandakanywa iBanga le-USP, ukuqinisekisa ukucoceka kwayo kunye nokufaneleka kwayo ukusetyenziswa kwezonyango.

Ukubaluleka kunye nezicelo

Ukubaluleka kweStreptomycin Sulfate kulele kumsebenzi wayo obanzi ngokuchasene neebhaktheriya ezininzi zeGram-negative kunye ne-Gram-positive. Isebenza ngokukodwa ekunyangeni isifo sephepha, isifo esosulelayo esinganyangekiyo esichaphazela imiphunga namanye amalungu omzimba. Indima yalo kunyango lwesifo sephepha ibe ngundoqo, kaninzi isebenza njengenxalenye kunyango oludityanisiweyo ukuqinisa ukusebenza ngempumelelo kunye nokuthintela ukukhula kokunganyangeki.

Ngapha koko, iStreptomycin Sulfate ifumana izicelo kunyango lwezilwanyana, ezolimo, kunye nezicwangciso zophando. Kwezolimo, inceda ukulawula izifo zebhaktiriya kwizityalo kunye nemfuyo, iphucula isivuno sezityalo kunye nempilo yezilwanyana. Abaphandi bakwasebenzisa iStreptomycin Sulfate ukufunda ngemfuzo yebhaktiriya, ukuxhathisa amayeza okubulala iintsholongwane, kunye neendlela zokwenziwa kweeprotheyini.

Indlela yokwenza

Indlela iStreptomycin Sulfate eyenza ngayo i-antibacterial effect ibandakanya ukuphazamisana ne-bacterial protein synthesis. Ngokukodwa, ibophelela kwi-ribosome yebhaktheriya, echaphazela ukukhethwa kokudluliselwa kwe-RNA (tRNA) ngexesha lokuguqulela. Oku kubopha kuphazamisa ukuchaneka kwe-decoding mRNA nge-ribosome, ekhokelela ekuvelisweni kweeprotheni ezingasebenzi okanye ezicutshiwe. Ngenxa yoko, iseli yebhaktiriya ayikwazi ukugcina imisebenzi yayo ebalulekileyo, nto leyo ephumela ekufeni kweeseli.

Okubangela umdla kukuba, ukuxhathisa kweStreptomycin Sulfate kuhlala kukwenza iimephu kwiinguqu kwiprotein ye-ribosomal S12. Ezi zantlukwano eziguqukayo zibonisa amandla aphezulu ocalucalulo ngexesha lokukhetha i-tRNA, ibenza ukuba bangachaphazeleki kakhulu kwiziphumo zesithinteli-ntsholongwane. Ukuqonda ezi ndlela zokuxhathisa kubalulekile ekuphuhliseni amacebo amatsha onyango kunye nokulwa nosoyikiso oluvelayo lokunganyangeki ngamayeza okubulala iintsholongwane.

Ukugcinwa kunye nokuphatha
Ngokufanelekileyo
ukugcinwa kunye nokuphathwa kweStreptomycin Sulfate kubalulekile ukugcina ukusebenza kwayo kunye nokhuseleko. Esi sithinteli-ntsholongwane kufuneka sigcinwe kumaqondo obushushu aphakathi kwe-2-8°C (36-46°F) kwisingxobo esivaliweyo, kude nokufuma nokukhanya. Ezi meko zinceda ukugcina uzinzo lwekhompawundi kwaye zithintele ukuthotywa.

Imarike kunye nokuFumana

I-Streptomycin Sulfate ifumaneka ngokubanzi kwimarike yoxubo mayeza, enikezelwa ngabavelisi abaninzi kunye nababoneleli kwihlabathi liphela. Amaxabiso anokwahluka ngokuxhomekeke kwizinto ezifana nebakala, ubumsulwa, kunye nobungakanani obuodolweyo. Umgangatho ophezulu weStreptomycin Sulfate, onje ngokudibana nemigangatho ye-USP, iyalela iprimiyamu ngenxa yovavanyo olungqongqo kunye nokuqinisekiswa kokucoceka.

Amathemba ekamva

Ngaphandle kwembali ende yokusetyenziswa, iStreptomycin Sulfate ihlala iyisithinteli-ntsholongwane esibalulekileyo kumlo ochasene nosulelo lwebhaktiriya. Njengoko abaphandi beqhubeka nokuphonononga amayeza amatsha kunye nezicwangciso zonyango, indima yeStreptomycin Sulfate inokuvela. Nangona kunjalo, ukusebenza kwayo okusekiweyo, umsebenzi we-spectrum ebanzi, kunye neendleko eziphantsi kakhulu ziyenza ibe lukhetho oluxabisekileyo kwiindawo ezininzi zeklinikhi kunye nophando.

Ukuqukumbela, iStreptomycin Sulfate bubungqina bamandla e-antibiotics kumayeza anamhlanje. Ikhono layo lokuthintela i-protein ye-bacterial synthesis kunye nokulwa nosulelo luye lwasindisa ubomi obungenakubalwa kwaye luqhubeka luyisiseko kwi-anti-infection therapy. Ngophando oluqhubekayo kunye nophuhliso lwe-antibiotics entsha, ilifa le-Streptomycin Sulfate ngokungathandabuzekiyo liya kunyamezela, libe negalelo kumzamo wehlabathi jikelele wokulwa nezifo ezithathelwanayo.