IVithamin C, ekwabizwa ngokuba yi-ascorbic acid, sisondlo esinyibilikayo emanzini. Abantu kunye nezinye izilwanyana (ezifana neeprimates, iihagu) zixhomekeke kwi-vitamin C kwisondlo seziqhamo kunye nemifuno (ipepile ebomvu, i-orenji, i-strawberry, i-broccoli, imango, i-lemon). Indima enokubakho ye-vitamin C ekukhuseleni nasekuphuculeni usulelo luye lwaqatshelwa kuluntu lwezonyango.
I-Ascorbic acid ibalulekile ekuphenduleni komzimba. Inomsebenzi obalulekileyo wokulwa nokuvuvukala, i-immunomodulatory, i-antioxidant, i-anti-thrombosis kunye ne-anti-viral properties.
I-Vitamin C ibonakala ikwazi ukulawula impendulo yomninimzi kwi-acute acute breathing syndrome ye-coronavirus 2 (SARS-CoV-2). ICoronavirus ngunobangela wobhubhani we-coronavirus ka-2019 (i-COVID-19), ngakumbi Ikwixesha elinzima. Kwingxelo yamva nje epapashwe kwi-Preprints *, uPatrick Holford et al. Isonjululwe indima kavithamin C njengonyango oluncedisayo kusulelo lokuphefumla, i-sepsis kunye ne-COVID-19.
Eli nqaku lixoxa ngendima enokubakho ye-vitamin C ekuthinteleni inqanaba elibalulekileyo le-COVID-19, usulelo oluqatha lokuphefumla kunye nezinye izifo ezivuthayo. Ukongezwa kweVithamin C kulindeleke ukuba ibe sisixhobo sothintelo okanye sonyango kwi-COVID-19-ukusilela okubangelwa sesi sifo, ukunciphisa uxinzelelo lwe-oxidative, ukomeleza imveliso ye-interferon kunye nokuxhasa iziphumo zokuchasa ukudumba kweglucocorticoids.
Ukuze kugcinwe amanqanaba eplasma aqhelekileyo kubantu abadala kwi-50 µmol/l, idosi ye-vitamin C yamadoda yi-90 mg/d kunye nabasetyhini i-80 mg/d. Oku kwanele ukukhusela i-scurvy (isifo esibangelwa ukungabikho kwe-vitamin C). Nangona kunjalo, eli nqanaba alanelanga ukukhusela ukuvezwa kwentsholongwane kunye noxinzelelo lomzimba.
Ngoko ke, i-Swiss Nutrition Society incoma ukuncedisa umntu ngamnye nge-200 mg ye-vitamin C-ukugcwalisa i-gap yesondlo sabantu bonke, ngakumbi abantu abadala be-65 iminyaka nangaphezulu. Esi songezo senzelwe ukomeleza amajoni omzimba. "
Ngaphantsi kweemeko zoxinzelelo lwe-physiological, amanqanaba e-serum ye-vitamin C ehla ngokukhawuleza. Isiqulatho se-serum yevithamin C kwizigulana ezilaliswe esibhedlele ngu-≤11µmol/l, kwaye uninzi lwabo luthwaxwa lusulelo olubukhali lokuphefumla, i-sepsis okanye i-COVID-19 eqatha.
Izifundo ezahlukeneyo ezivela kwihlabathi liphela zibonisa ukuba amanqanaba asezantsi evithamin C aqhelekile kwizigulana ezigula kakhulu ezinosulelo lokuphefumla, inyumoniya, i-sepsis kunye ne-COVID-19-eyona nkcazo inokwenzeka kukwanda kokusetyenziswa kwe-metabolic.
Uhlalutyo lwemeta luqaqambise oku kulandelayo: 1) Ukongezwa kweVithamin C kunokunciphisa kakhulu umngcipheko wenyumoniya, 2) Uphando lwasemva kobhubhani emva kokubhubha kwe-COVID-19 lubonise inyumoniya yesibini, kwaye 3) Ukunqongophala kweVithamin C kubalele kubo bonke abantu abanale ngxaki. inyumoniya 62%.
I-Vitamin C inesiphumo esibalulekileyo se-homeostatic njenge-antioxidant. Kuyaziwa ukuba inomsebenzi wokubulala intsholongwane ngokuthe ngqo kwaye inokunyusa imveliso ye-interferon. Ineendlela ezisebenzayo kuzo zombini izixokelelwano zokuzikhusela ezizalwa kunye neziguquguqukayo. I-Vitamin C inciphisa iintlobo ze-oksijeni ezisebenzayo (ROS) kunye nokuvuvukala ngokunciphisa ukusebenza kwe-NF-κB.
I-SARS-CoV-2 phantsi-ilawula ukubonakaliswa kohlobo loku-1 lwe-interferon (eyona ndlela yokukhusela i-antiviral ye-antiviral), ngelixa i-ascorbic acid iphakamisa-ilawula ezi proteni zingundoqo zokukhusela.
Inqanaba elibalulekileyo le-COVID-19 (elihlala linqanaba elibulalayo) lenzeka ngexesha lokuveliswa ngokugqithisileyo kweecytokines kunye neekhemokines ezisebenza ngokusukileyo. Oku kwakhokelela ekuphuhlisweni kokusilela kwamalungu amaninzi. Inxulumene nokufuduka kunye nokuqokelelwa kwe-neutrophils kwi-lung interstitium kunye ne-bronchoalveolar cavity, le yokugqibela ibe yinto ephambili yokumisela i-ARDS (i-Acute Respiratory Distress Syndrome).
I-concentration ye-ascorbic acid kwi-adrenal glands kunye ne-pituitary gland iphindwe kathathu ukuya kwishumi eliphezulu kunalo naliphi na ilungu. Ngaphantsi koxinzelelo lwe-physiological (ACTH stimulation) iimeko ezibandakanya ukuvezwa kwentsholongwane, i-vitamin C ikhutshwa kwi-adrenal cortex, ebangela ukuba amanqanaba e-plasma anyuke ngokuphindwe kahlanu.
I-Vitamin C inokunyusa ukuveliswa kwe-cortisol, kwaye iphucule i-anti-inflammatory kunye ne-endothelial cell effect ekhuselayo ye-glucocorticoids. I-Exogenous glucocorticoid steroids kuphela kweziyobisi ezithe zangqina ukunyanga i-COVID-19. I-Vitamin C i-multi-effect stimulating hormone, edlala indima ebalulekileyo ekulungelelaniseni impendulo yoxinzelelo lwe-adrenal cortex (ingakumbi i-sepsis) kunye nokukhusela i-endothelium kumonakalo we-oxidative.
Ukuthathela ingqalelo ifuthe levithamin C kwingqele-ukunciphisa ixesha, ubungqongqo kunye nokuphindaphinda kokuthatha ivithamin C ebandayo kunokunciphisa utshintsho ukusuka kusulelo olungephi ukuya kwixesha elibalulekileyo le-COVID-19.
Kuye kwaphawulwa ukuba ukongezwa kwevithamin C kunokunciphisa ubude bokuhlala kwi-ICU, kucuthe ixesha lokungena umoya kwizigulana ezigula kakhulu nge-COVID-19, kunye nokunciphisa izinga lokusweleka kwezigulana ze-sepsis ezifuna unyango nge-vasopressors.
Ukuqwalasela iimeko ezahlukeneyo zohudo, amatye entso kunye nokungaphumeleli kwezintso ngexesha eliphezulu, ababhali baxubusha ukhuseleko lomlomo kunye nokulawulwa kwe-intravenous ye-vitamin C. I-dose ekhuselekileyo yexesha elifutshane le-2-8 g / ngosuku inokunconywa ( ngononophelo uphephe iidosi eziphezulu kubantu abanembali yamatye ezintso okanye isifo sezintso). Ngenxa yokuba i-soluble yamanzi, inokukhutshwa kwiiyure ezimbalwa, ngoko ke i-dosage frequency ibalulekile ukugcina amanqanaba aneleyo egazi ngexesha losulelo olusebenzayo.
Njengoko sonke siyazi, i-vitamin C inokuthintela usulelo kwaye iphucule impendulo yomzimba. Ngokukodwa ngokubhekisele kwinqanaba elibalulekileyo le-COVID-19, ivithamin C idlala indima ebalulekileyo. Iphantsi-ilawula isivunguvungu se-cytokine, ikhusela i-endothelium kumonakalo we-oxidative, idlala indima ebalulekileyo ekulungiseni izicubu, kwaye iphucula impendulo yokuzivikela kwintsholongwane.
Umbhali ucebisa ukuba izongezo ze-vitamin C kufuneka zongezwe yonke imihla ukukhuthaza amaqela asemngciphekweni omkhulu wokusweleka kwe-COVID-19 kunye nokunqongophala kwevithamin C. Kufuneka bahlale beqinisekisa ukuba i-vitamin C yanele kwaye inyuse umthamo xa intsholongwane isuleleke, ukuya kwi-6-8 g / ngosuku. Inani lezifundo ezixhomekeke kumthamo wevithamin C ezixhomekeke kwidosi ziyaqhuba kwihlabathi liphela ukuqinisekisa indima yazo ekudambiseni i-COVID-19 kunye nokuqonda ngcono indima yayo njengento enokubakhona kunyango.
Iipreprints ziya kupapasha iingxelo zokuqala zenzululwazi ezingakhange zihlolwe ngoontanga, kwaye ngoko ke akufanele zithathwe njengento ecacileyo, ekhokelayo yokusebenza kweklinikhi / ukuziphatha okunxulumene nempilo okanye kuthathelwe ingqalelo ulwazi olucacileyo.
Iithegi: isifo sokuphefumla esiqatha, anti-ukudumba, i-antioxidant, i-ascorbic acid, igazi, i-broccoli, i-chemokine, i-coronavirus, isifo se-coronavirus COVID-19, i-corticosteroid, i-cortisol, i-cytokine, i-cytokine, urhudo, ukuphindaphinda, iGlucocorticoids, iihomoni, impendulo yomzimba, i-immune inkqubo, ukuvuvukala, i-interstitial, izintso, isifo sezintso, ukusilela kwezintso, ukufa, isondlo, uxinzelelo lwe-oxidative, ubhubhane, inyumoniya, ukuphefumla, i-SARS-CoV-2, i-scurvy, i-Sepsis, isifo esibukhali sokuphefumla, isifo esibukhali sokuphefumla, iqunube, uxinzelelo, isifo, imifuno, intsholongwane, ivithamin C.
URamya unePhD. IPune National Chemical Laboratory (CSIR-NCL) ifumene iPhD kwiBiotechnology. Umsebenzi wakhe uquka ukusebenza kwe-nanoparticles ezineamolekyuli ezahlukeneyo zomdla webhayoloji, ukufunda iinkqubo zokusabela kunye nokwakha izicelo eziluncedo.
Dwivedi, Ramya. (2020, Okthobha 23). IVithamin C kunye ne-COVID-19: Uphononongo. Iindaba zonyango. Ifunyanwa kwakhona ku-https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx nge-12 kaNovemba, 2020.
Dwivedi, Ramya. "IVithamin C kunye ne-COVID-19: Uphononongo." Iindaba zonyango. NgoNovemba 12, 2020. .
Dwivedi, Ramya. "IVithamin C kunye ne-COVID-19: Uphononongo." Iindaba zonyango. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Ifunyenwe ngoNovemba 12, 2020).
Dwivedi, Ramya. 2020. "IVithamin C kunye ne-COVID-19: Uphononongo." I-News-Medical, yakhangelwa ngoNovemba 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Kolu dliwano-ndlebe, uNjingalwazi uPaul Tesar kunye noKevin Allan bapapashe iindaba kwiijenali zeendaba zonyango malunga nendlela amanqanaba asezantsi eoksijini ayonakalisa ngayo ingqondo.
Kolu dliwano ndlebe, uGqr. Jiang Yigang uxoxe nge-ACROBiosystems kunye neenzame zayo zokulwa i-COVID-19 kunye nokufumana amayeza okugonya.
Kulo dliwano-ndlebe, i-News-Medical ixoxe ngokuphuhliswa kunye nokubonakaliswa kwe-antibodies ye-monoclonal kunye noDavid Apiyo, umphathi ophezulu wezicelo kwi-Sartorius AG.
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Sisebenzisa iikuki ukuphucula amava akho. Ngokuqhubeka nokukhangela le webhusayithi, uyavumelana nokusetyenziswa kwethu kweekuki. Iinkcukacha ezithe xaxe.