I-Cimetidine ichiza elivimba ukuveliswa kwe-asidi ngeeseli ezivelisa i-asidi esiswini kwaye inokulawulwa ngomlomo, i-IM okanye i-IV.

I-Cimetidine isetyenziselwa ukwenza:

• khululaisitshisaidityaniswa neukugaywa kweasidikunye nesisu esimuncu
• thintela isitshisa esiziswa kukutya okanye ukusela ukutya okuthile kunyeiziselo

Yeyodidi lweiziyobisiebizwa ngokuba yi-H2 (histamine-2) blockers ekwabandakanya nayoranitidine(Zantac),nizatidine(I-Axid), kwayefamotidine(Pepcid). I-Histamine yikhemikhali eyenzeka ngokwemvelo evuselela iiseli esiswini (iiseli ze-parietal) ukuba zivelise i-asidi. I-H2-blockers inqanda isenzo se-histamine kwiiseli, ngaloo ndlela inciphisa ukuveliswa kwe-asidi ngesisu.

Ekubeni i-asidi egqithisileyo yesisu inokonakalisaummizo, isisu, kunye ne-duodenum nge-reflux kwaye ikhokelela ekudumbeni kunye nesilonda, ukunciphisa i-asidi yesisu ikhusela kwaye ivumela ukuvuvukala okubangelwa yi-asidi kunye nezilonda ukuba ziphilise. I-Cimetidine yavunywa yi-FDA kwi-1977.