Ucwaningo lwaseDenmark lwabonisa ukuthi ezigulini ezine-acute obstructive pulmonary disease (COPD), i-amoxicillin iyodwa inemiphumela engcono kune-amoxicillin ehlanganiswe nenye i-antibiotic, i-clavulanic acid.
Ucwaningo olunesihloko esithi "I-Antibiotic Therapy in Acute Exacerbations of COPD: Imiphumela Yesiguli Ye-Amoxicillin ne-Amoxicillin/Clavulanic Acid-Data Evela Ezigulini Ezingaphandle Kwe-43,636" yanyatheliswa ku-Journal of Respiratory Research.
Ukwanda okukhulu kwe-COPD kuyisenzakalo lapho izimpawu zesiguli ziba zimbi ngokuzumayo. Njengoba lokhu kubhebhetheka ngokuvamile kuhlobene nokungenwa amagciwane, ukwelashwa ngama-antibiotic (izidakamizwa ezibulala amagciwane) kuyingxenye yezinga lokunakekelwa.
E-Denmark, kunezinhlobo ezimbili zama-antibiotic ezivame ukusetshenziswa ezingasetshenziswa ukwelapha ukukhushulwa okunjalo. Enye ingama-750 mg we-amoxicillin kathathu ngosuku, kanti enye i-500 mg ye-amoxicillin kanye ne-125 mg ye-clavulanic acid, futhi kathathu ngosuku.
I-Amoxicillin ne-clavulanic acid womabili ama-beta-lactam, okungama-antibiotic asebenza ngokuphazamisa ukukhiqizwa kwezindonga zamangqamuzana amagciwane, ngaleyo ndlela abulale amagciwane.
Umgomo oyisisekelo wokuhlanganisa lawa ma-antibiotic amabili ukuthi i-clavulanic acid iyasebenza ngokumelene nezinhlobo eziningi zamagciwane. Kodwa-ke, ukwelashwa nge-amoxicillin kukodwa kusho ukuthi isibulala-magciwane esisodwa singanikezwa ngethamo eliphezulu, elingase libulale amagciwane ngempumelelo kakhudlwana.
Manje, iqembu labacwaningi baseDenmark liqhathanise ngokuqondile imiphumela yalezi zinhlobo ezimbili zemithi yokwelapha ukukhushulwa okunamandla kwe-COPD.
Abacwaningi basebenzise idatha evela kurejista ye-Danish COPD, ehlanganiswe nedatha evela kwamanye amarejista kazwelonke, ukukhomba iziguli ze-43,639 ezinezimo ezimbi ezithole enye yezinketho ezimbili ezihlaziywe. Ngokuqondile, abantu abayi-12,915 baphuze i-amoxicillin yodwa futhi abantu abangama-30,721 bathatha inhlanganisela yemithi. Kuyaqapheleka ukuthi asikho nesisodwa isiguli esahlaziywa esilaliswe esibhedlela ngenxa yokushuba kweCOPD, okukhombisa ukuthi ukuhlasela bekungebi kakhulu.
Uma kuqhathaniswa nenhlanganisela ye-amoxicillin ne-clavulanic acid, ukwelashwa nge-amoxicillin kuphela kunganciphisa ubungozi bokulaliswa esibhedlela okuhlobene nenyumoniya noma yonke imbangela yokufa ngama-40% ngemuva kwezinsuku ezingama-30. I-Amoxicillin iyodwa futhi ihlotshaniswa nokuncipha kwe-10% engcupheni yokulaliswa esibhedlela okungeyona inyumoniya noma yokufa kanye nokuncipha okungama-20% kwengozi yokulaliswa esibhedlela noma yokushona kwayo yonke imbangela.
Kuzo zonke lezi zinyathelo, umehluko phakathi kwalokhu kwelashwa okubili ubalulekile ngokwezibalo. Ukuhlaziywa kwezibalo okwengeziwe ngokuvamile kuzothola imiphumela engaguquki.
Abacwaningi babhale: "Sithole ukuthi uma kuqhathaniswa ne-AMC [i-amoxicillin kanye ne-clavulanic acid], i-AECOPD [i-COPD exacerbation] iziguli ezilashwa nge-AMX [i-amoxicillin iyodwa] zisengcupheni yokulaliswa esibhedlela noma yokufa ngenxa yenyumoniya zingakapheli izinsuku ezingama-30 Iphansi kakhulu."
Ithimba liqagela ukuthi esinye isizathu esingaba khona salo mphumela umehluko wemithamo phakathi kwemithi emibili elwa namagciwane.
"Uma isetshenziswa ngethamo elifanayo, i-AMC [inhlanganisela] mancane amathuba okuba ibe ngaphansi kune-AMX [i-amoxicillin yodwa]," babhala.
Sekukonke, ukuhlaziya "kusekela ukusetshenziswa kwe-AMX njengokwelashwa okuncamelayo kwamagciwane ezigulini ezingaphandle nge-AECOPD," abacwaningi baphetha ngokuthi "ukwengezwa kwe-clavulanic acid ku-amoxicillin akuhlangene nemiphumela engcono."
Ngokusho kwabacwaningi, umkhawulo oyinhloko wocwaningo ingozi yokudideka ngenxa yezinkomba-ngamanye amazwi, abantu asebevele besesimweni esibi bangase bathole ukwelashwa okuhlangene. Nakuba ukuhlaziya izibalo zabacwaningi kuzama ukuchaza lesi sici, kusengenzeka ukuthi umehluko wangaphambi kokwelashwa uchaze eminye yemiphumela.
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