Ukuphathwa kanyekanye kwe-ivermectin, i-diethylcarbamazine, ne-albendazole kuqinisekisa i-pharmacotherapy enkulu ephephile

ethula:

Ekuthuthukisweni kwezinhlelo zezempilo zomphakathi, abacwaningi bakuqinisekisile ukuphepha nokusebenza kwenhlanganisela yezidakamizwa ezinkulu ze-ivermectin, i-diethylcarbamazine (DEC) ne-albendazole. Le ntuthuko enkulu izoba nomthelela omkhulu emizamweni yomhlaba yokulwa nezifo ezahlukahlukene ezinganakiwe zasezindaweni ezishisayo (NTDs).

ingemuva:

Izifo ezinganakiwe zasezindaweni ezishisayo zithinta abantu abangaphezu kwebhiliyoni emazweni ampofu futhi zibeka izinselele ezinkulu empilweni yomhlaba wonke. I-Ivermectin isetshenziswa kabanzi ekwelapheni izifo ezinamagciwane, okuhlanganisa nobumpumputhe bomfula, kuyilapho i-DEC ihlose i-lymphatic filariasis. I-Albendazole iyasebenza ekulweni nezikelemu zamathumbu. Ukuphatha ngokubambisana kwale mithi kungabhekana nama-NTD amaningi ngesikhathi esisodwa, okwenza izinhlobo zokwelapha zisebenze kahle futhi zingabizi.

Ukuphepha nokusebenza kahle:

Ucwaningo lwakamuva olwenziwe ithimba labacwaningi bamazwe ngamazwe luhlose ukuhlola ukuphepha kokuthatha le mithi emithathu ndawonye. Icala libandakanya ababambiqhaza abangaphezu kuka-5,000 emazweni amaningi, kuhlanganisa nalawo anama-co-infections. Imiphumela yocwaningo ibonise ukuthi ukwelapha okuhlangene kwakubekezelelwe kahle futhi kwaba nemiphumela emibi emincane. Okuqaphelekayo, ukwenzeka kanye nokuqina kwezehlakalo ezimbi kwakufana nalezo ezibonwa lapho umuthi ngamunye uthathwa wodwa.

Ngaphezu kwalokho, ukusebenza kahle kwezinhlanganisela zemithi emikhulu kuyamangaza. Ababambiqhaza babonise ukuncipha okukhulu komthwalo we-parasite kanye nemiphumela yomtholampilo ethuthukisiwe kuzo zonke izifo ezilashwayo. Lo mphumela awugcini nje ngokugqamisa umphumela we-synergistic wezokwelapha ezihlanganisiwe kodwa futhi unikeza ubufakazi obengeziwe bokwenzeka nokusimama kwezinhlelo zokulawula eziphelele ze-NTD.

Umthelela empilweni yomphakathi:

Ukuqaliswa ngempumelelo kwemithi eyinhlanganisela kuletha ithemba elikhulu lemisebenzi emikhulu yokwelapha izidakamizwa. Ngokuhlanganisa imithi emithathu ebalulekile, lezi zinhlelo zingenza imisebenzi ibe lula futhi inciphise izindleko nobunzima bokusebenza obuhambisana nokuqhuba izinhlelo zokwelashwa ezihlukene. Ukwengeza, ukusebenza kahle okwandisiwe kanye nemiphumela engemihle encishisiwe yenza le ndlela idume kakhulu, iqinisekise ukuthotshelwa kwemithetho nemiphumela engcono.

Imigomo yokuqeda umhlaba wonke:

Inhlanganisela ye-ivermectin, i-DEC ne-albendazole ihambisana ne-World Health Organization (WHO) yomgwaqo yokuqedwa kwama-NTD. I-Sustainable Development Goals (SDGs) ibiza ukulawulwa, ukuqedwa noma ukuqedwa kwalezi zifo ngo-2030. Le nhlanganisela yokwelapha imele isinyathelo esibalulekile ekufinyeleleni le migomo, ikakhulukazi ezifundeni lapho ama-NTD amaningi ehlala khona.

ithemba:

Ukuphumelela kwalolu cwaningo kuvula indlela yamasu anwetshiwe okwelapha adidiyelwe. Abacwaningi njengamanje baphenya amandla okufaka eminye imithi eqondene ne-NTD emithi yokwelapha eyinhlanganisela, njenge-praziquantel ye-schistosomiasis noma i-azithromycin ye-trachoma. Lezi zinyathelo zikhombisa ukuzibophezela komphakathi wesayensi ekuzimeni nasekuthuthukiseni izinhlelo zokulawula ze-NTD.

Izinselelo neziphetho:

Nakuba ukuphathwa ngokubambisana kwe-ivermectin, i-DEC, ne-albendazole kunikeza izinzuzo ezinkulu, izinselele zisekhona. Ukujwayela lezi zinketho zokwelapha ezindaweni ezihlukene zezwe, ukuqinisekisa ukufinyeleleka, kanye nokunqoba izithiyo zokuhlela kuzodinga umzamo wokubambisana phakathi kohulumeni, izinhlangano zamazwe ngamazwe, nabahlinzeki bezempilo. Nokho, amandla okwenza ngcono imiphumela yezempilo yomphakathi ezigidini zezigidi zabantu azidlula kude lezi zinselele.

Ekuphetheni, inhlanganisela ephumelelayo ye-ivermectin, i-DEC, ne-albendazole inikeza isisombululo esiwusizo nesiphephile sokwelashwa okukhulu kwezifo ezinganakwa ezishisayo. Le ndlela ebanzi inesithembiso esihle sokufinyelela imigomo yokuqeda umhlaba wonke futhi igqamisa ukuzinikela komphakathi wesayensi ekubhekaneni ngqo nezinselelo zempilo yomphakathi. Ngocwaningo olwengeziwe kanye nezinhlelo eziqhubekayo, ikusasa lokulawula kwe-NTD libonakala likhanya kunangaphambili.