I-Vitamin C, eyaziwa nangokuthi i-ascorbic acid, isakhi esibalulekile esincibilika emanzini. Abantu nezinye izilwane (ezifana nezinkawu, izingulube) bathembele kuvithamini C ekunikezeni ukudla okunomsoco kwezithelo nemifino (upelepele obomvu, iwolintshi, sitrobheli, ibroccoli, umango, ulamula). Indima engaba khona kavithamini C ekuvimbeleni nasekuthuthukiseni izifo iye yaqashelwa emphakathini wezokwelapha.
I-Ascorbic acid ibalulekile ekuphenduleni amasosha omzimba. Ine-anti-inflammatory, immunomodulatory, antioxidant, anti-thrombosis kanye ne-antiviral properties.
UVithamini C ubonakala ekwazi ukulawula ukusabela komsingathi ku-acute acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). ICoronavirus iyimbangela yobhubhane lwe-coronavirus yango-2019 (COVID-19), ikakhulukazi Isesikhathini esibucayi. Ekuphawuleni kwakamuva okushicilelwe ku-Preprints*, uPatrick Holford et al. Ixazulule indima kavithamini C njengokwelashwa okuyisizayo kwezifo zokuphefumula, i-sepsis kanye ne-COVID-19.
Le ndatshana idingida indima engaba khona kavithamini C ekuvimbeleni isigaba esibucayi se-COVID-19, izifo ezithinta ukuphefumula okunzima nezinye izifo ezivuthayo. Ukwengezwa kwe-Vitamin C kulindeleke ukuthi kube i-ejenti yokuvimbela noma yokwelapha yokushoda kokulungisa i-COVID-19 okubangelwa yilesi sifo, kunciphise ingcindezi ye-oxidative, kuthuthukise ukukhiqizwa kwe-interferon futhi kusekele imiphumela yokulwa nokuvuvukala kwama-glucocorticoids.
Ukuze kugcinwe amazinga ajwayelekile e-plasma kubantu abadala ku-50 µmol/l, umthamo wevithamini C wabesilisa ngu-90 mg/d futhi kwabesifazane u-80 mg/d. Lokhu kwanele ukuvimbela i-scurvy (isifo esibangelwa ukuntuleka kwevithamini C). Nokho, leli zinga alanele ukuvimbela ukuchayeka kwegciwane kanye nokucindezeleka komzimba.
Ngakho-ke, i-Swiss Nutrition Society incoma ukuthi kufakwe umuntu ngamunye nge-200 mg kavithamini C-ukugcwalisa igebe lokudla okunempilo komphakathi jikelele, ikakhulukazi abantu abadala abaneminyaka engu-65 nangaphezulu. Lesi sengezo senzelwe ukuqinisa amasosha omzimba. "
Ngaphansi kwezimo zokucindezeleka ngokomzimba, amazinga e-serum kavithamini C ehla ngokushesha. Okuqukethwe kwe-serum kavithamini C ezigulini ezilaliswe esibhedlela ngu-≤11µmol/l, futhi iningi lazo lihlushwa ukutheleleka kokuphefumula okunamandla, i-sepsis noma i-COVID-19 enzima.
Ucwaningo oluhlukahlukene oluvela emhlabeni wonke lukhombisa ukuthi amazinga aphansi kavithamini C ajwayelekile ezigulini ezigula kakhulu ezinezifo zokuphefumula, inyumoniya, i-sepsis kanye ne-COVID-19-incazelo okungenzeka kakhulu ukuthi ukwanda kokusetshenziswa kwe-metabolic.
Ukuhlaziywa kwe-meta kuqokomise lokhu okuphawuliwe okulandelayo: 1) Ukwengezwa kwe-Vitamin C kunganciphisa kakhulu ingozi yenyumoniya, 2) Uphenyo lwangemuva kokushona kwe-COVID-19 lwabonisa inyumoniya yesibili, kanye 3) Ukuntuleka kuka-Vitamin C kubalele ingqikithi yabantu abanayo. inyumoniya 62%.
I-Vitamin C inomphumela obalulekile we-homeostatic njenge-antioxidant. Kuyaziwa ukuthi inomsebenzi oqondile wokubulala igciwane futhi ingakhuphula ukukhiqizwa kwe-interferon. Inezinqubo zomphumela kuwo womabili amasosha omzimba azalwa nawo futhi aguquguqukayo. I-Vitamin C inciphisa izinhlobo ze-oksijeni ezisebenzayo (ROS) nokuvuvukala ngokunciphisa ukusebenza kwe-NF-κB.
I-SARS-CoV-2 ilawula phansi-ilawula ukuvezwa kohlobo 1 lwe-interferon (indlela eyinhloko yokuvikela elwa namagciwane), kuyilapho i-ascorbic acid inyusa ilawula lawa maprotheni abalulekile okuvikela.
Isigaba esibucayi se-COVID-19 (imvamisa isigaba esibulalayo) senzeka ngesikhathi sokukhiqizwa ngokweqile kwama-cytokines nama-chemokines asebenza ngempumelelo abangela ukuvuvukala. Lokhu kwaholela ekuthuthukisweni kokwehluleka kwezitho eziningi. Ihlobene nokufuduka nokunqwabelana kwama-neutrophils ku-lung interstitium kanye ne-bronchoalveolar cavity, lokhu kwakamuva kuyisici esiyinhloko se-ARDS (Acute Respiratory Distress Syndrome).
Ukugcwala kwe-ascorbic acid ezindlala ze-adrenal kanye ne-pituitary kuphindwe kathathu kuya kweyishumi kunanoma yisiphi esinye isitho. Ngaphansi kwezimo ze-physiological stress (ACTH stimulation) okuhlanganisa ukuchayeka kwegciwane, uvithamini C ukhishwa ku-adrenal cortex, okwenza amazinga e-plasma anyuke ngokuphindwe kahlanu.
I-Vitamin C ingathuthukisa ukukhiqizwa kwe-cortisol, futhi ithuthukise imiphumela elwa nokuvuvukala kanye ne-endothelial cell protective ye-glucocorticoids. I-Exogenous glucocorticoid steroids ukuphela kwezidakamizwa ezifakazelwe ukuthi zelapha i-COVID-19. I-Vitamin C iyi-hormone evuselela imiphumela eminingi, edlala indima ebalulekile ekuxhumaniseni impendulo yokucindezeleka kwe-adrenal cortex (ikakhulukazi i-sepsis) nokuvikela i-endothelium emonakalweni we-oxidative.
Ukucabangela umphumela kavithamini C emakhazeni-ehlisa ubude besikhathi, ukuqina kanye nemvamisa kavithamini C othatha umkhuhlane kunganciphisa uguquko olusuka ekuthelelekeni olungelutho luye esikhathini esibucayi se-COVID-19.
Kuye kwaqashelwa ukuthi ukwengezwa kwe-vitamin C kungafinyeza ubude bokuhlala e-ICU, kufinyeze isikhathi sokungena komoya seziguli ezigula kakhulu ezine-COVID-19, futhi kunciphise izinga lokufa kweziguli ze-sepsis ezidinga ukwelashwa ngama-vasopressors.
Ngokucabangela izimo ezihlukahlukene zohudo, amatshe ezinso kanye nokwehluleka kwezinso ngesikhathi sokulinganisa okuphezulu, abalobi baxoxisana nokuphepha kokuphathwa komlomo kanye ne-intravenous ye-vitamin C. Isilinganiso esiphezulu esiphephile sesikhathi esifushane se-2-8 g / ngosuku singanconywa. gwema ngokucophelela imithamo ephezulu kubantu abanomlando wezinso noma isifo sezinso). Ngenxa yokuthi ayincibiliki emanzini, ingakhishwa phakathi namahora ambalwa, ngakho-ke imvamisa yomthamo ibalulekile ukugcina amazinga egazi anele ngesikhathi sokutheleleka okusebenzayo.
Njengoba sonke sazi, i-vitamin C ingavimbela ukutheleleka futhi ithuthukise ukuphendula kwamasosha omzimba. Ikakhulukazi ibhekisa esigabeni esibucayi se-COVID-19, uvithamini C udlala indima ebalulekile. Ilawula phansi-ilawula isiphepho se-cytokine, ivikela i-endothelium emonakalweni we-oxidative, idlala indima ebalulekile ekulungiseni izicubu, futhi ithuthukise ukuphendula kwamasosha omzimba ekuthelelekeni.
Umbhali uncoma ukuthi izithasiselo zikavithamini C kufanele zengezwe nsuku zonke ukukhuthaza amaqembu asengozini enkulu yokufa okuphezulu kwe-COVID-19 kanye nokuntuleka kukavithamini C. Kufanele ngaso sonke isikhathi baqinisekise ukuthi uvithamini C wanele futhi andise umthamo lapho igciwane lithelelekile, kuze kufike ku-6-8 g/ngosuku. Izifundo eziningi ezincike ku-vitamin C ezincike kumthamo ziyaqhubeka emhlabeni wonke ukuze ziqinisekise indima yazo ekudambiseni i-COVID-19 kanye nokuqonda kangcono indima yayo njengamandla okwelapha.
Ama-Preprints azoshicilela imibiko yokuqala yesayensi engakabuyekezwa ngontanga, ngakho-ke akufanele kubhekwe njengokuphethayo, umkhuba womtholampilo oqondisayo/ukuziphatha okuhlobene nempilo noma okubhekwa njengolwazi oluqondile.
Tags: acute respiratory distress syndrome, anti-inflammatory, antioxidant, ascorbic acid, igazi, broccoli, chemokine, i-coronavirus, isifo se-coronavirus COVID-19, i-corticosteroid, i-cortisol, i-cytokine, i-cytokine, isifo sohudo, imvamisa, I-Glucocorticoids, amahomoni, impendulo yokuzivikela komzimba, i-immune uhlelo, ukuvuvukala, i-interstitial, izinso, isifo sezinso, ukwehluleka kwezinso, ukufa, umsoco, ukucindezeleka okwenziwe nge-oxidative, ubhubhane, inyumoniya, ukuphefumula, i-SARS-CoV-2, i-scurvy, i-Sepsis, isifo esinzima sokuphefumula, isifo sokuphefumula esinamandla, sitrobheli, ingcindezi, isifo, imifino, igciwane, uvithamini C.
URamya unePhD. I-Pune National Chemical Laboratory (CSIR-NCL) ithole i-PhD ku-Biotechnology. Umsebenzi wakhe uhlanganisa ukusebenzisa ama-nanoparticles anama-molecule ahlukene ezinto eziphilayo, ukutadisha amasistimu wokusabela nokwakha izinhlelo zokusebenza eziwusizo.
Dwivedi, Ramya. (2020, Okthoba 23). I-Vitamin C ne-COVID-19: Isibuyekezo. Izindaba zezokwelapha. Kubuyiswe ku-https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ngoNovemba 12, 2020.
Dwivedi, Ramya. "I-Vitamin C ne-COVID-19: Isibuyekezo." Izindaba zezokwelapha. Novemba 12, 2020. .
Dwivedi, Ramya. "I-Vitamin C ne-COVID-19: Isibuyekezo." Izindaba zezokwelapha. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Kufinyelelwe ngoNovemba 12, 2020).
Dwivedi, Ramya. 2020. "I-Vitamin C ne-COVID-19: Isibuyekezo." I-News-Medical, yapheqululwa ngoNovemba 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Kule ngxoxo, uProfesa uPaul Tesar noKevin Allan bashicilele izindaba emaphephandabeni ezempilo wezindaba mayelana nokuthi amazinga aphansi komoyampilo alimaza kanjani ubuchopho.
Kule ngxoxo, uDkt. Jiang Yigang uxoxe nge-ACROBiosystems nemizamo yayo yokulwa ne-COVID-19 kanye nokuthola imigomo.
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